Acquired pure red cell aplasia (acquired PRCA) is a rare disorder of the bone marrow that affects red blood cells (erythrocytes). Erythrocytes are responsible for delivering oxygen to different parts of the body through the circulatory system. Acquired PRCA is most common in adults and can be caused by autoimmune diseases such as diabetes, certain cancers, viral infections, and pregnancy complications. In rare cases, a mismatched bone marrow transplant can cause PRCA.
Individuals with this condition will have very few red blood cells (anemia) which leads to the symptoms that are seen in this disorder. Symptoms of PRCA include fatigue, lethargy, and pale skin. The severity of symptoms depends on the severity of the disease, and some patients may show no symptoms at all. Erythropoietin is a hormone that helps produce red blood cells. Individuals with PRCA may have abnormally high levels of erythropoietin.
This condition is diagnosed based on a medical history and blood testing. Treatment for PRCA will depend on the underlying cause. The symptoms of PCRA will usually resolve once the underlying condition is properly treated. Talk to your doctor about the most current treatment options for PRCA.