Acrokeratosis verruciformis of Hopf is a rare genetic disorder that mainly involves problems with the skin. Specifically, individuals with this condition have multiple flat, symmetrical skin-colored marks on different parts of the skin. These marks, also called lesions, are most often found on the top of the hands and feet. There may also be small, raised pimples on the knees, elbows, and forearms. Individuals with acrokeratosis verruciformis of Hopf may have nails with ridges and marks. Symptoms of acrokeratosis verruciformis of Hopf are usually present from birth or appear during early childhood. Sometimes, symptoms do not begin until adulthood.
Acrokeratosis verruciformis of Hopf is a genetic condition caused by a change, or mutation, in the ATP2A2 gene. Acrokeratosis verruciformis of Hopf is passed down from parent to child in an autosomal dominant manner. This means only one mutation from one parent is inherited in order to cause symptoms. A person with this condition has a 50/50 chance of passing the condition on to their children.
Doctors can clinically diagnose acrokeratosis verruciformis of Hopf by looking at markings on the skin. Sometimes, doctors may also take a sample of the skin to help with the diagnosis. There is no treatment that is required for this condition since it cannot spread to other parts of the body or cause complications. If individuals want to get rid of the skin lesions, they can choose to do so. If you or a family member has been diagnosed with acrokeratosis verruciformis of Hopf, talk with your doctor about the most current treatment options. Support groups are also good resources of support and information.
Description Last Updated: Feb 25, 2018