Alzheimer's Disease

Common Name(s)

Alzheimer's Disease

Alzheimer's disease is a progressive condition of the brain that affects memory, thinking, and behavior. It is the most common form of dementia, a term that refers to any condition that worsens mental functioning over time. Alzheimer's disease is most common in individuals 65 years and older, but cases of early onset have been documented in individuals in their 40s and 50s.

Alzheimer's is caused by two abnormal protein structures ("plaques" which are protein deposits and "tangles" which are twisted protein fibers) found in the brain tissue along with the loss of connection between neurons (nerve cells in the brains). These abnormalities cause the brain cells to lose normal function. It is uncertain what causes these abnormalities to develop but several genes have been identified as risk factors. Environmental factors and behaviors such as alcoholism have been linked to Alzheimer's disease as well.

The first sign of Alzheimer's is an inability to remember newly learned information. As the condition progresses over time, the individual may experience worsening memory loss, changes in mood or behavior and eventually severe confusion (in terms of time, events, or places), disorientation, and unnecessary suspicions about family or others. The individual may progress to the point that he or she cannot take care of him or herself, eat or swallow, speak, or walk. A diagnosis for Alzheimer’s is not definitive but is based upon a combination of looking at someone's family history, a physical exam, and other tests. Plaques and tangles are not seen on MRI or other brain scans. Genetic testing may also be helpful in some familial cases.

There is currently no cure for Alzheimer's, but drug treatments are available to slow the progression, manage the symptoms, and improve quality of life. If you or someone you know is diagnosed with Alzheimer’s disease, contact your doctor to discuss the most current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Alzheimer's Disease" for support, advocacy or research.

Alzheimer's Association

The mission of the Alzheimer's Association is to eliminate Alzheimer's disease through the advancement of research; to provide and enhance care and support for all affected; and to reduce the risk of dementia through the promotion of brain health.

Last Updated: 7 Jul 2015

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Alzheimer's Disease Education and Referral Center

The Alzheimer's Disease Education and Referral Center was established by the National Institute on Aging (NIA) to provide information to health professionals, patients and their families and the public about Alzheimer's disease and other memory disorders.

Last Updated: 30 Oct 2014

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Alzheimer's Foundation of America

To provide optimal care and services to individuals confronting dementia, and to their caregivers and families--through member organizations dedicated to improving quality of life.

Last Updated: 9 Apr 2014

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HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

Last Updated: 9 Jul 2015

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National Endowment for Alzheimer's Research

At NEAR, our mission is to investigate the underlying causes of Alzheimer's and to develop rapid clinical interventions both for Alzheimer's and other brain disorders. A secondary mission is to promote public awareness and education with respect to Alzheimer's disease and related dementia, and to encourage the involvement of individuals, businesses, foundations, and government in finding a cure.

Last Updated: 20 Dec 2012

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Alzheimer's Disease" for support, advocacy or research.

Alzheimer's Association

The mission of the Alzheimer's Association is to eliminate Alzheimer's disease through the advancement of research; to provide and enhance care and support for all affected; and to reduce the risk of dementia through the promotion of brain health.

http://www.alz.org

Last Updated: 7 Jul 2015

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Alzheimer's Disease Education and Referral Center

The Alzheimer's Disease Education and Referral Center was established by the National Institute on Aging (NIA) to provide information to health professionals, patients and their families and the public about Alzheimer's disease and other memory disorders.

http://www.nia.nih.gov/alzheimers

Last Updated: 30 Oct 2014

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Alzheimer's Foundation of America

To provide optimal care and services to individuals confronting dementia, and to their caregivers and families--through member organizations dedicated to improving quality of life.

http://www.alzfdn.org

Last Updated: 9 Apr 2014

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HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

http://www.healthywomen.org

Last Updated: 9 Jul 2015

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National Endowment for Alzheimer's Research

At NEAR, our mission is to investigate the underlying causes of Alzheimer's and to develop rapid clinical interventions both for Alzheimer's and other brain disorders. A secondary mission is to promote public awareness and education with respect to Alzheimer's disease and related dementia, and to encourage the involvement of individuals, businesses, foundations, and government in finding a cure.

http://www.memorymatters.org

Last Updated: 20 Dec 2012

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General Support Organizations

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General Resources

Alzheimer's Association Helpline

The Alzheimer's Association 24/7 Helpline provides reliable information and support to all those who need assistance. Call us toll-free anytime day or night at 800.272.3900. Our 24/7 Helpline serves people with memory loss, caregivers, health care professionals and the public.

Updated 15 Oct 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Alzheimer's Disease" returned 7266 free, full-text research articles on human participants. First 3 results:

PPARγ agonist-loaded PLGA-PEG nanocarriers as a potential treatment for Alzheimer's disease: in vitro and in vivo studies.
 

Author(s): Marcelle Silva-Abreu, Ana Cristina Calpena, Pol Andrés-Benito, Ester Aso, Ignacio A Romero, David Roig-Carles, Radka Gromnicova, Marta Espina, Isidre Ferrer, María Luisa García, David Male

Journal:

 

The first aim of this study was to develop a nanocarrier that could transport the peroxisome proliferator-activated receptor agonist, pioglitazone (PGZ) across brain endothelium and examine the mechanism of nanoparticle transcytosis. The second aim was to determine whether these nanocarriers ...

Last Updated: 31 Dec 1969

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Natural Scaffolds with Multi-Target Activity for the Potential Treatment of Alzheimer's Disease.
 

Author(s): Luca Piemontese, Gabriele Vitucci, Marco Catto, Antonio Laghezza, Filippo Maria Perna, Mariagrazia Rullo, Fulvio Loiodice, Vito Capriati, Michele Solfrizzo

Journal:

 

A few symptomatic drugs are currently available for Alzheimer's Disease (AD) therapy, but these molecules are only able to temporary improve the cognitive capacity of the patients if administered in the first stages of the pathology. Recently, important advances have been achieved ...

Last Updated: 31 Dec 1969

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Synthesis and Biological Evaluation of New Cholinesterase Inhibitors for Alzheimer's Disease.
 

Author(s): Weiam Hussein, Begüm Nurpelin Sağlık, Serkan Levent, Büşra Korkut, Sinem Ilgın, Yusuf Özkay, Zafer Asım Kaplancıklı

Journal:

 

Alzheimer's disease (AD) is a neurodegenerative disorder mostly influencing the elderly, and causes death due to dementia. The main pathogenic feature connected with the progression of this multifactorial disease is the weakening of the cholinergic system in the brain. Cholinesterase ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Alzheimer's Disease" returned 1982 free, full-text review articles on human participants. First 3 results:

Untangling the Tauopathy for Alzheimer's disease and parkinsonism.
 

Author(s): Hui-Yun Chang, Tzu-Kang Sang, Ann-Shyn Chiang

Journal:

 

Tau is a microtubule-associated protein that mainly localizes to the axon to stabilize axonal microtubule structure and neuronal connectivity. Tau pathology is one of the most common proteinopathies that associates with age-dependent neurodegenerative diseases including Alzheimer's ...

Last Updated: 31 Dec 1969

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Recent Insights on Alzheimer's Disease Originating from Yeast Models.
 

Author(s): David Seynnaeve, Mara Del Vecchio, Gernot Fruhmann, Joke Verelst, Melody Cools, Jimmy Beckers, Daniel P Mulvihill, Joris Winderickx, Vanessa Franssens

Journal:

 

In this review article, yeast model-based research advances regarding the role of Amyloid-β (Aβ), Tau and frameshift Ubiquitin UBB in Alzheimer’s disease (AD) are discussed. Despite having limitations with regard to intercellular and cognitive AD aspects, these models ...

Last Updated: 31 Dec 1969

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Apolipoprotein E Gene Polymorphisms Affect the Efficacy of Thiazolidinediones for Alzheimer's Disease: A Systematic Review and Meta-Analysis.
 

Author(s): Ryo Iketani, Keiko Ohno, Yohei Kawasaki, Kunihiro Matsumoto, Hiroshi Yamada, Satoshi Kishino

Journal: Biol. Pharm. Bull.. 2018 ;41(7):1017-1023.

 

Although several studies have evaluated the efficacy of thiazolidinediones (TZD) for the treatment of Alzheimer's disease (AD), investigation of the impact of apolipoprotein E (ApoE) gene polymorphisms on the efficacy of TZD remains insufficient. We investigated the impact by conducting ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Early Onset Alzheimer's Disease Genomic Study
 

Status: Recruiting

Condition Summary: Alzheimer Disease

 

Last Updated: 7 Sep 2018

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Memantine Treatment in Alzheimer's Disease Patients
 

Status: Not yet recruiting

Condition Summary: Alzheimer Disease

 

Last Updated: 25 May 2017

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