Alzheimer's disease early onset

Common Name(s)

Alzheimer's disease early onset

Alzheimer's disease, early onset is a progressive condition of the brain that affects memory, thinking, and behavior that occurs before the age of 65. Only 5% of cases of Alzheimer's are considered early onset.

Causes for this early onset of Alzheimer's disease are often genetic, but environmental and behavioral factors may also play a role, just like in traditional Alzheimer's disease (See: Alzheimer's disease). Early onset Alzheimer's disease has the same symptoms including: difficulty remembering newly learned information, memory loss, behavioral changes, disorientation, confusion, and unnecessary suspicion of family or others. These symptoms may progress to an inability to care for him or herself, to eat, or to speak. Because Alzheimer's is typically a disease of old age, early onset Alzheimer's often goes misdiagnosed as stress or another condition. It may take multiple doctors visits and second opinions to find the correct diagnosis. Early onset Alzheimer's can be particularly devastating, but if caught early, the symptoms can potentially be managed and quality of life improved.

There is no cure for either early onset or for traditional "late onset" Alzheimer's. However, there are medications available that may help to slow the progression of the disease and help with some of the symptoms. It is important to talk to your doctor as soon as possible if you or a family member may have early onset Alzheimer's. Genetic testing may be available to help you and your family predict and manage your risks.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Alzheimer's disease early onset" for support, advocacy or research.

Logo
National Endowment for Alzheimer's Research

At NEAR, our mission is to investigate the underlying causes of Alzheimer's and to develop rapid clinical interventions both for Alzheimer's and other brain disorders. A secondary mission is to promote public awareness and education with respect to Alzheimer's disease and related dementia, and to encourage the involvement of individuals, businesses, foundations, and government in finding a cure.

Last Updated: 20 Dec 2012

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Alzheimer's disease early onset" for support, advocacy or research.

Logo
National Endowment for Alzheimer's Research

At NEAR, our mission is to investigate the underlying causes of Alzheimer's and to develop rapid clinical interventions both for Alzheimer's and other brain disorders. A secondary mission is to promote public awareness and education with respect to Alzheimer's disease and related dementia, and to encourage the involvement of individuals, businesses, foundations, and government in finding a cure.

http://www.memorymatters.org

Last Updated: 20 Dec 2012

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Alzheimer's disease early onset" returned 87 free, full-text research articles on human participants. First 3 results:

A pathogenic p.His169Asn mutation associated with early-onset Alzheimer's disease.
 

Author(s): Vo Van Giau, Jung-Min Pyun, Eva Bagyinszky, Seong Soo A An, SangYun Kim

Journal:

 

Autosomal dominant early-onset Alzheimer's disease (EOAD) is genetically heterogeneous and has been associated with mutations in 3 different genes, coding for amyloid precursor protein (APP), presenilin 1 (PSEN1), and presenilin 2 (PSEN2). Most frequent cases are associated with mutations ...

Last Updated: 31 Dec 1969

Go To URL
Pathologically Confirmed Cerebral Amyloid Angiopathy with No Radiological Sign in a Patient with Early Onset Alzheimer's Disease.
 

Author(s): Seung Joo Kim, Youjeong Seo, Hee Jin Kim, Duk L Na, Sang Won Seo, Yeshin Kim, Yeon Lim Suh

Journal: Yonsei Med. J.. 2018 Aug;59(6):801-805.

 

Cerebral amyloid angiopathy (CAA) is associated with perivascular disruption, which is caused by progressive amyloid-beta (Aβ) deposition in vessels. Previous autopsy studies have shown that the prevalence of CAA in Alzheimer's disease (AD) is 70% to 90%. CAA is principally characterized ...

Last Updated: 31 Dec 1969

Go To URL
Differentiation of neuropsychological features between posterior cortical atrophy and early onset Alzheimer's disease.
 

Author(s): Jieying Li, Liyong Wu, Yi Tang, Aihong Zhou, Fen Wang, Yi Xing, Jianping Jia

Journal:

 

Posterior cortical atrophy (PCA) is a group of clinical syndromes characterized by visuospatial and visuoperceptual impairment, with memory relatively preserved. Although PCA is pathologically almost identical to Alzheimer's disease (AD), they have different cognitive features. Those ...

Last Updated: 31 Dec 1969

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Alzheimer's disease early onset" returned 7 free, full-text review articles on human participants. First 3 results:

Elucidating Pathogenic Mechanisms of Early-onset Alzheimer's Disease in Down Syndrome Patients.
 

Author(s): Masashi Asai, Takashi Kawakubo, Ryotaro Mori, Nobuhisa Iwata

Journal: Yakugaku Zasshi. 2017 ;137(7):801-805.

 

Down syndrome (DS) patients demonstrate the neuropathology of Alzheimer's disease (AD) characterized by the formation of senile plaques and neurofibrillary tangles by age 40-50 years. It has been considered for a number of years that 1.5-fold expression of the gene for the amyloid ...

Last Updated: 31 Dec 1969

Go To URL
Mutations, associated with early-onset Alzheimer's disease, discovered in Asian countries.
 

Author(s): Eva Bagyinszky, Young Chul Youn, Seong Soo A An, SangYun Kim

Journal:

 

Alzheimer's disease (AD), the most common form of senile dementia, is a genetically complex disorder. In most Asian countries, the population and the number of AD patients are growing rapidly, and the genetics of AD has been extensively studied, except in Japan. However, recent studies ...

Last Updated: 31 Dec 1969

Go To URL
Molecular genetics of early-onset Alzheimer's disease revisited.
 

Author(s): Rita Cacace, Kristel Sleegers, Christine Van Broeckhoven

Journal: Alzheimers Dement. 2016 06;12(6):733-48.

 

As the discovery of the Alzheimer's disease (AD) genes, APP, PSEN1, and PSEN2, in families with autosomal dominant early-onset AD (EOAD), gene discovery in familial EOAD came more or less to a standstill. Only 5% of EOAD patients are carrying a pathogenic mutation in one of the AD ...

Last Updated: 31 Dec 1969

Go To URL
 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Longitudinal Early-onset Alzheimer's Disease Study Protocol
 

Status: Recruiting

Condition Summary: Early Onset Alzheimer Disease; Alzheimer Disease; Mild Cognitive Impairment

 

Last Updated: 7 Nov 2018

Go to URL
Early Onset Alzheimer's Disease Genomic Study
 

Status: Recruiting

Condition Summary: Alzheimer Disease

 

Last Updated: 7 Sep 2018

Go to URL
Early-onset Alzheimer's Disease Phenotypes: Neuropsychology and Neural Networks
 

Status: Recruiting

Condition Summary: Alzheimer Disease, Early Onset; Alzheimer Disease; Alzheimer Disease, Late Onset; Dementia, Alzheimer Type; Logopenic Progressive Aphasia; Primary Progressive Aphasia; Visuospatial/Perceptual Abilities; Posterior Cortical Atrophy; Executive Dysfunction; Corticobasal Degeneration; Ideomotor Apraxia

 

Last Updated: 15 Oct 2018

Go to URL