Amelogenesis imperfecta type IC is a disease affecting tooth development. It is one of fourteen subtypes of amelogenesis imperfecta, which are grouped based on their specific tooth defects.
Symptoms of AI type 1C include small or discolored teeth, pitting and grooving in the teeth, and teeth that break easily. Compared to other types of AI, type IC usually involved small crowns of the teeth, upper and lower teeth that do not meet, and teeth that vary from off-white to yellow-brown in color. AI type IC can occur on its own or as a result of another disease that affects multiple parts of the body.
AI type IC is a typically genetic condition caused by mutations (changes) in the ENAM gene. We inherit our genes in pairs, one from each parent typically. AI type IC is inherited in an autosomal recessive manner. Autosomal recessive means that an individual must have two copies of the changed gene or mutation that causes the condition. A person with one changed gene would be a carrier of the condition but usually will not have any symptoms. If both parents are carriers of the condition, each child has a one in four chance (25%) of having the disease.
AI type IC is usually diagnosed by physically examining the teeth, family history, and X-rays to look at the teeth when they erupt. Usually, diagnosis can be made between the ages of one and two years old.
Treatment for the condition usually involves full crown restorations and dentures that corrects the way the teeth meet. If you or a family member has been diagnosed with amelogenesis imperfecta type IC, talk to your doctor about the most current treatment options. Support groups are also a good source of information.
Description Last Updated: Aug 29, 2018