Amyloid neuropathy

Common Name(s)

Amyloid neuropathy

Amyloid neuropathy is a general term that describes a group of disorders that affect the nerves and other parts of the nervous system. Damage to the nerves is caused by the accumulation of abnormal proteins called amyloids. As a result, individuals with amyloid neuropathy usually have many sensory problems. Symptoms include painful sensations, numbness, balance difficulties, nausea, vomiting, diarrhea, constipation, uncontrolled urine leakage, excessive sweating, and/or sexual dysfunction. This condition is diagnosed through family history, nerve conduction studies, skin, nevre or muscle biopsies, and in cases of familial amyloidosis, genetic testing may be available. Currently, treatments for this condition are symptom relief and the prevention of amyloids spreading to other parts of the body. Anti-seizure medications or anti-depressants may help with nerve pain, and depending on the type of amyloids, patients may benefit from liver or bone marrow transplants. Talk with your doctor if you or a familly member has been diagnosed with an amyloid neuropathy. Support organizations are also a good source of information and can help you connect with others living with amyloid neuropathy.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Amyloid neuropathy" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Amyloid neuropathy" returned 18 free, full-text research articles on human participants. First 3 results:

C1q ablation exacerbates amyloid deposition: A study in a transgenic mouse model of ATTRV30M amyloid neuropathy.
 

Author(s): Elena Panayiotou, Eleni Fella, Revekka Papacharalambous, Stavros Malas, Maria Joao Saraiva, Theodoros Kyriakides

Journal:

 

ATTRV30M amyloid neuropathy is a lethal autosomal dominant sensorimotor and autonomic neuropathy, caused by deposition of amyloid fibrils composed of aberrant transthyretin (TTR). Ages of onset and penetrance exhibit great variability and genetic factors have been implicated. Complement ...

Last Updated: 31 Dec 1969

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Transthyretin amyloid neuropathy has earlier neural involvement but better prognosis than primary amyloid counterpart: an answer to the paradox?
 

Author(s): Adam J Loavenbruck, Wolfgang Singer, Michelle L Mauermann, Paola Sandroni, P James B Dyck, Morie Gertz, Christopher J Klein, Phillip A Low

Journal: Ann. Neurol.. 2016 Sep;80(3):401-11.

 

To systematically compare transthyretin with primary amyloid neuropathy to define their natural history and the underlying mechanisms for differences in phenotype and natural history.

Last Updated: 31 Dec 1969

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Sudomotor innervation in transthyretin amyloid neuropathy: Pathology and functional correlates.
 

Author(s): Chi-Chao Chao, Cho-Min Huang, Hao-Hua Chiang, Kai-Ren Luo, Hung-Wei Kan, Naomi Chu-Chiao Yang, Hao Chiang, Whei-Min Lin, Shu-Mei Lai, Ming-Jen Lee, Chia-Tung Shun, Sung-Tsang Hsieh

Journal: Ann. Neurol.. 2015 Aug;78(2):272-83.

 

Autonomic neuropathy is a major component of familial amyloid polyneuropathy (FAP) due to mutated transthyretin, with sudomotor failure as a common manifestation. This study aimed to investigate the pathology and clinical significance of sudomotor denervation.

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Amyloid neuropathy" returned 0 free, full-text review articles on human participants.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Expanding the Biomarkers in Familial Amyloid Neuropathy: MRI and Motor Unit Estimation by Electrophysiological Study
 

Status: Not yet recruiting

Condition Summary: Amyloid Neuropathies; Transthyretin Amyloidosis

 

Last Updated: 17 Jul 2018

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Assessment of the Prevalence of TTR Amyloid Neuropathy in a Population of Patients With Neuropathy of Unknown Aetiology
 

Status: Recruiting

Condition Summary: Familial Amyloid Neuropathy; Transthyretin Amyloidosis

 

Last Updated: 17 Nov 2017

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Early and Systematic Screening in Chronic Neuropathy
 

Status: Not yet recruiting

Condition Summary: Amyloid Neuropathies, Familial

 

Last Updated: 24 Oct 2018

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