Anaphylaxis

Common Name(s)

Anaphylaxis

Anaphylaxis is a serious, rare, generalized allergic reaction to an allergen. Normally your immune system helps protect you from viruses and bacteria. An allergic reaction occurs when the body’s immune system responds to and attacks a harmless substance or allergen. Some common allergens include certain foods, medications, pollen, pet dander, perfumes, insect venom, and chemicals. Unlike a mild to moderate allergic reaction, anaphylaxis may be life threatening. Symptoms of anaphylaxis may include pale, clammy skin, weak and rapid pulse, trouble breathing, confusion and lack of consciousness. Without medical treatment, a coma and life threatening complications may occur.

Anaphylaxis is rare but usually happens when a person becomes very sensitive to a specific allergen. Risk factors of anaphylaxis include a previous experience with anaphylaxis, having allergies, and family history of anaphylaxis. In order to isolate the allergen causing the reaction, a doctor or specialist may perform special skin or blood tests. Your doctor may also ask you questions about what you ate or were doing just before the attack. In addition, your doctor will want to rule out other possible causes of your symptoms. Treatments include medications such as epinephrine, oxygen, IV antihistamines, and beta-agonists such as albuterol. More aggressive measures may be necessary if an individual stops breathing or their heart stops. Individuals at risk for anaphylaxis may carry an epinephrine autoinjector to use in an emergency. Anaphylaxis requires immediate medical attention. If you have been diagnosed as having an anaphylactic reaction, talk with your doctor about the best way to prevent the reaction and the most current treatment options.

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Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Anaphylaxis" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Anaphylaxis" returned 814 free, full-text research articles on human participants. First 3 results:

[Asystole during surgery to manage small intestine cancer: are we dealing with anaphylaxis or carcinoid crisis].
 

Author(s): Ismail Aissa, Aziz Benakrout, Mohamed Meziane, Mustapha Bensghir, Salim Jaafar Lalaoui

Journal:

 

Cardiac arrest in the operating room is a life-threatening event with multiple causes. We report the case of a 53-year old female patient with no particular past medical history scheduled for surgery to manage small intestine cancer. Twenty minutes after anesthetic induction the patient ...

Last Updated: 31 Dec 1969

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Prevalence triggers and clinical severity associated with anaphylaxis at a tertiary care facility in Saudi Arabia: A cross-sectional study.
 

Author(s): Raghad Alkanhal, Ibrahim Alhoshan, Sadal Aldakhil, Nouf Alromaih, Nesrin Alharthy, Mahmoud Salam, Adel F Almutairi

Journal: Medicine (Baltimore). 2018 Aug;97(31):e11582.

 

Anaphylaxis is a systemic and hypersensitive allergic reaction caused by various triggers such as environmental, food, drug, and insects. The aim of this study was to identify the prevalence, triggers, and clinical severity of anaphylaxis in 2 emergency departments (EDs) in Saudi ...

Last Updated: 31 Dec 1969

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Anaphylaxis-related Malpractice Lawsuits.
 

Author(s): Rachel A Lindor, Erika M McMahon, Joseph P Wood, Annie T Sadosty, Eric T Boie, Ronna L Campbell

Journal: West J Emerg Med. 2018 Jul;19(4):693-700.

 

Anaphylaxis continues to cause significant morbidity and mortality. Healthcare providers struggle to promptly recognize and appropriately treat anaphylaxis patients. The goal of this study was to characterize anaphylaxis-related malpractice lawsuits.

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Anaphylaxis" returned 96 free, full-text review articles on human participants. First 3 results:

Clinically suspected anaphylaxis induced by sugammadex in a patient with Weaver syndrome undergoing restrictive mammoplasty surgery: A case report with the literature review.
 

Author(s): Nurdan Bedirli, Berrin Işık, Mehrnoosh Bashiri, Kutluk Pampal, Ömer Kurtipek

Journal: Medicine (Baltimore). 2018 Jan;97(3):e9661.

 

Sugammadex is a cylodextrin derivate that encapsulates steroidal neuromuscular blocker agents and is reported as a safe and well-tolerated drug. In this case report, we present a patient who developed grade 3 anaphylaxis just after sugammadex administration.

Last Updated: 31 Dec 1969

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Diagnosis and treatment of anaphylaxis: there is an urgent needs to implement the use of guidelines.
 

Author(s): Maria Luiza Kraft Köhler Ribeiro, Herberto José Chong Neto, Nelson Augusto Rosario Filho

Journal: Einstein (Sao Paulo). ;15(4):500-506.

 

Anaphylaxis is a severe, life-threatening generalized or systemic hypersensitivity reaction that requires rapid and adequate care. This study aimed to obtain an integrated view of the level of physicians' knowledge related with treatment of anaphylaxis in studies published within ...

Last Updated: 31 Dec 1969

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Fatal Anaphylaxis: Mortality Rate and Risk Factors.
 

Author(s): Paul J Turner, Elina Jerschow, Thisanayagam Umasunthar, Robert Lin, Dianne E Campbell, Robert J Boyle

Journal: J Allergy Clin Immunol Pract. ;5(5):1169-1178.

 

Up to 5% of the US population has suffered anaphylaxis. Fatal outcome is rare, such that even for people with known venom or food allergy, fatal anaphylaxis constitutes less than 1% of total mortality risk. The incidence of fatal anaphylaxis has not increased in line with hospital ...

Last Updated: 31 Dec 1969

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Cause of Unexplained Anaphylaxis
 

Status: Recruiting

Condition Summary: Anaphylaxis

 

Last Updated: 10 Nov 2018

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Use of Dexamethasone in Prevention of the Second Phase or a Biphasic Reaction of Anaphylaxis
 

Status: Recruiting

Condition Summary: Mild -Moderate Anaphylaxis - Symptoms That Affect the Skin With Cardiovascular, Respiratory or Gastrointestinal Involvement, But no Signs of Hypotension ,Laryng

 

Last Updated: 1 May 2018

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Inhibition of Anaphylaxis by Ibrutinib
 

Status: Recruiting

Condition Summary: Food Allergy; Anaphylaxis Food

 

Last Updated: 9 May 2017

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