Anaplastic astrocytoma

Common Name(s)

Anaplastic astrocytoma

Anaplastic astrocytoma is a rare cancerous brain tumor that grows from star shaped cells called astrocytes. Astrocytes make up the protective tissue of the brain. Astrocytoma tumors are characterized by "grade" (grade I-IV) which is based on how normal or abnormal the tumor cells appear as well as how fast the tumor is growing. With this system, grade I shows the cells are abnormal but not yet cancerous. Anaplastic astrocytoma is considered a a grade III tumor and requires more aggressive treatment. Astrocytoma tumors are characterized by tentacle-like projections that grow into surround tissues making them more difficult to remove during surgery. Initial symptoms may include headaches, memory loss, depressed mental state, and/or seizures. Other neurological deficits or changes may appear depending on where the tumors spread. Currently there is no known cause for this type of tumor, although a small proportion of individuals (< 5%) may develop anaplastic astrocytoma due to hereditary factors. Anaplasitc astrocyomas tend to occur more frequently in males than females and generally after age 45. Treatment procedures involve surgery first, and then radiation therapy to remove any remaining tumor tissue. Chemotherapy may be necessary if the tumor returns. If you or a family member has been diagnosed with an anaplastic astrosytoma, talk with your doctors and specialists to learn about the most current treatment options available.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Anaplastic astrocytoma" for support, advocacy or research.

Accelerate Brain Cancer Cure

Our Mission: to invest in research aimed at finding the fastest possible route to a cure. We are focused on speeding the pace of research that will lead to new brain tumor therapies and, ultimately, a cure. We take an aggressive, venture funding approach not typically seen in the nonprofit sector. We have an enterprising attitude, we promote scientific collaboration and we're committed to measurable results.

Last Updated: 7 Jan 2013

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National Brain Tumor Society

National Brain Tumor Society is fiercely committed to finding better treatments, and ultimately a cure, for people living with a brain tumor today and anyone who will be diagnosed tomorrow. This means effecting change in the system at all levels. It’s time to build on progress and transform tomorrow, today.

Last Updated: 21 Nov 2014

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Anaplastic astrocytoma" for support, advocacy or research.

Accelerate Brain Cancer Cure

Our Mission: to invest in research aimed at finding the fastest possible route to a cure. We are focused on speeding the pace of research that will lead to new brain tumor therapies and, ultimately, a cure. We take an aggressive, venture funding approach not typically seen in the nonprofit sector. We have an enterprising attitude, we promote scientific collaboration and we're committed to measurable results.

http://www.abc2.org

Last Updated: 7 Jan 2013

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National Brain Tumor Society

National Brain Tumor Society is fiercely committed to finding better treatments, and ultimately a cure, for people living with a brain tumor today and anyone who will be diagnosed tomorrow. This means effecting change in the system at all levels. It’s time to build on progress and transform tomorrow, today.

http://braintumor.org/

Last Updated: 21 Nov 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Anaplastic astrocytoma" returned 51 free, full-text research articles on human participants. First 3 results:

Anaplastic astrocytoma with aquaporin-4 positive in CSF: A case report.
 

Author(s): Yuanyuan Liu, Feng Gao, Hongjun Hao, Weiping Sun, Yining Huang

Journal: Medicine (Baltimore). 2017 Dec;96(51):e9193.

 

An acute presentation with diffuse magnetic resonance imaging lesions can have a broad differential. Demyelination and malignancy are important considerations. Therefore, sometimes it is hard to differentiate glioma from some demyelinating diseases solely on imaging because of the ...

Last Updated: 31 Dec 1969

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Crossed Aphasia in a Patient with Anaplastic Astrocytoma of the Non-Dominant Hemisphere.
 

Author(s): Stephanie Prater, Neil Anand, Lawrence Wei, Neil Horner

Journal:

 

Aphasia describes a spectrum of speech impairments due to damage in the language centers of the brain. Insult to the inferior frontal gyrus of the dominant cerebral hemisphere results in Broca's aphasia - the inability to produce fluent speech. The left cerebral hemisphere has historically ...

Last Updated: 31 Dec 1969

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Extracranial bone metastases from recurrent anaplastic astrocytoma on FDG PET/CT: A case report a care-compliant article.
 

Author(s): Zu-Gui Li, Hai-Yu Mu

Journal: Medicine (Baltimore). 2017 Jun;96(23):e7123.

 

Extracranial bone metastases from astrocytoma are rare and frequently detected as part of multiorgan metastases. It is extremely rare for astrocytoma to have extracranial bone metastases alone. The importance of whole-body fluorodeoxyglucose positron emission tomography/computed tomography ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Anaplastic astrocytoma" returned 3 free, full-text review articles on human participants. First 3 results:

Anaplastic astrocytoma mimicking progressive multifocal leucoencephalopathy: a case report and review of the overlapping syndromes.
 

Author(s): Ema Kantorová, Michal Bittšanský, Štefan Sivák, Eva Baranovičová, Petra Hnilicová, Vladimír Nosáľ, Daniel Čierny, Kamil Zeleňák, Wolfgang Brück, Egon Kurča

Journal:

 

Co-occurrence of multiple sclerosis (MS) and glial tumours (GT) is uncommon although occasionally reported in medical literature. Interpreting the overlapping radiologic and clinical characteristics of glial tumours, MS lesions, and progressive multifocal leukoencephalopathy (PML) ...

Last Updated: 31 Dec 1969

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Adult anaplastic pilocytic astrocytoma - a diagnostic challenge? A case series and literature review.
 

Author(s): Michael Fiechter, Ekkehard Hewer, Urspeter Knecht, Roland Wiest, Jürgen Beck, Andreas Raabe, Markus F Oertel

Journal: Clin Neurol Neurosurg. 2016 Aug;147():98-104.

 

Anaplastic pilocytic astrocytoma (APA) is an exceptionally rare type of high-grade glioma in adults. Establishing histopathological diagnosis is challenging and its clinical and radiological appearance insidious. By this case series and first literature review we investigated the ...

Last Updated: 31 Dec 1969

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Anaplastic astrocytoma.
 

Author(s): Sean A Grimm, Marc C Chamberlain

Journal: CNS Oncol. 2016 Jul;5(3):145-57.

 

Anaplastic astrocytoma (AA) is a diffusely infiltrating, malignant, astrocytic, primary brain tumor. AA is currently defined by histology although future classification schemes will include molecular alterations. AA can be separated into subgroups, which share similar molecular profiles, ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study to Evaluate Eflornithine + Lomustine vs Lomustine in Recurrent Anaplastic Astrocytoma (AA) Patients
 

Status: Recruiting

Condition Summary: Anaplastic Astrocytoma; Recurrent Anaplastic Astrocytoma

 

Last Updated: 26 Sep 2018

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CB-839 With Radiation Therapy and Temozolomide in Treating Participants With IDH-Mutated Diffuse Astrocytoma or Anaplastic Astrocytoma
 

Status: Not yet recruiting

Condition Summary: Anaplastic Astrocytoma, IDH-Mutant; Diffuse Astrocytoma, IDH-Mutant; IDH1 Gene Mutation; IDH2 Gene Mutation

 

Last Updated: 16 Jul 2018

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Immunophenotyping From Blood of Patients With Malignant Gliomas
 

Status: Recruiting

Condition Summary: Anaplastic Astrocytoma; Glioblastoma Multiforme

 

Last Updated: 24 Jan 2018

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