Anaplastic large cell lymphoma

Common Name(s)

Anaplastic large cell lymphoma

Anaplastic large cell lymphoma (ALCL) is a type of non-Hodgkin lymphoma (NHL), which is a kind of blood cancer, that involves abnormal T-cells (please also visit: Non-Hodgkin Lymphoma.). T cells are a type of white blood cell in your body that help fight diseases. These abnormal T-cells may build up in the lymph nodes (small oval-shaped immune system organs) causing them to swell. Common symptoms include painless swelling in the neck, armpit, or groin due to the enlarged lymph nodes. Other symptoms include loss of appetite, tiredness, night sweats, fevers, or weight loss. ALCL can initially appear in either skin, lymph nodes or other organs throughout the body. When it appears in the skin, it is called primary cutaneous ALCL and has a less aggressive disease course. ALCL is diagnosed through the examination of any enlarged lymph nodes. Further inspection may be required through a biopsy in which doctors will remove the lymph node itself. Other tests include bone marrow samples, blood tests, x-rays or scans. ALCL is divided into two types at present, depending on whether or not their cells have an abnormal form of a protein on their surface called "anaplastic lymphoma kinase" (ALK). ALK- positive ALCL is considered more likely to affect children or young adults and responds well to standard chemotherapy treatments, putting most patients in long-term remission. ALK-negative ALCL more likely affects individuals over 60 and although it responds well to treatment at first, it is more likely to return. The causes of ALCL are currently unknown. However, it is neither infectious nor can it be passed on to other people. The main treatment for ALCL is chemotherapy, but radiotherapy and/or stem cell treatment may be recommended. Talk to your doctor to see if you or a family member has been diagnosed with this condition to find the most current treatment options available.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Anaplastic large cell lymphoma" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

Last Updated: 20 Feb 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Anaplastic large cell lymphoma" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

http://www.nbmtlink.org

Last Updated: 20 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Anaplastic large cell lymphoma" returned 371 free, full-text research articles on human participants. First 3 results:

Small cell variant of ALK-positive anaplastic large cell lymphoma with primary subcutaneous presentation: A case report.
 

Author(s): Tang-Her Jaing, Tsung-Yen Chang, Shih-Hsiang Chen, Yu-Chuan Wen, Wen-Yu Chuang, Chao-Ping Yang

Journal: Medicine (Baltimore). 2018 Jun;97(26):e11222.

 

The rare morphological variant of anaplastic large cell lymphoma (ALCL) may pose a challenge in diagnosis, especially when presentation primarily involves skin lesions.

Last Updated: 31 Dec 1969

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Anaplastic large cell lymphoma localized to the left breast years after radiotherapy for breast cancer.
 

Author(s): Michelle S Min, Ali Al-Haseni, Farah Succaria, Lynne Goldberg, Adam Lerner, Debjani Sahni

Journal:

 

Anaplastic large cell lymphoma (ALCL) is a rare type of non-Hodgkin lymphoma that can involve the skin primarily or secondarily. Our case describes an unusual presentation of eruptive tumors localized to the leftbreast region several years following breast cancer surgery and radiation ...

Last Updated: 31 Dec 1969

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Phase I clinical study of brentuximab vedotin (SGN-35) involving children with recurrent or refractory CD30-positive Hodgkin's lymphoma or systemic anaplastic large cell lymphoma: rationale, design and methods of BV-HLALCL study: study protocol.
 

Author(s): Masahiro Sekimizu, Akihiro Iguchi, Tetsuya Mori, Yuhki Koga, Akiko Kada, Akiko M Saito, Keizo Horibe

Journal:

 

Hodgkin's lymphoma (HL) and anaplastic large-cell lymphoma (ALCL) are the two most common tumors expressing CD30. Internationally, a clinical study that is being conducted involving adults with recurrent or refractory HL or ALCL suggests efficacy of brentuximab vedotin (SGN-35). Pediatric ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Anaplastic large cell lymphoma" returned 38 free, full-text review articles on human participants. First 3 results:

Anaplastic large cell lymphoma: pathology, genetics, and clinical aspects.
 

Author(s): Naoko Tsuyama, Kana Sakamoto, Seiji Sakata, Akito Dobashi, Kengo Takeuchi

Journal: J Clin Exp Hematop. 2017 ;57(3):120-142.

 

Anaplastic large cell lymphoma (ALCL) was first described in 1985 as a large-cell neoplasm with anaplastic morphology immunostained by the Ki-1 antibody, which recognizes CD30. In 1994, the nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) fusion receptor tyrosine kinase was identified ...

Last Updated: 31 Dec 1969

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Anaplastic lymphoma kinase-positive large B-cell lymphoma: Clinico-pathological study of 17 cases with review of literature.
 

Author(s): Xiang-Nan Jiang, Bao-Hua Yu, Wei-Ge Wang, Xiao-Yan Zhou, Xiao-Qiu Li

Journal:

 

We retrospectively analysed 17 cases of anaplastic lymphoma kinase-positive large B-cell lymphoma (ALK+, LBCL) according to the morphological, immunohistochemical, molecular and clinical features, using which we intend to elucidate the clinicopathological characteristics of this rare ...

Last Updated: 31 Dec 1969

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ALK-positive anaplastic large cell lymphoma undiagnosed in a patient with tuberculosis: a case report and review of the literature.
 

Author(s): Weerapat Owattanapanich, Pakpoom Phoompoung, Sanya Sukpanichnant

Journal:

 

Due to a similarity between the features of lymphoma and the features of tuberculosis, lymphoma may go unrecognized and undiagnosed in patients with tuberculosis.

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of Brentuximab Vedotin in Patients With Relapsed or Refractory Systemic Anaplastic Large Cell Lymphoma
 

Status: Recruiting

Condition Summary: Anaplastic Large-cell Lymphoma

 

Last Updated: 11 Jul 2018

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Ceritinib With Brentuximab Vedotin in Treating Patients With ALK-Positive Anaplastic Large Cell Lymphoma
 

Status: Recruiting

Condition Summary: Anaplastic Large Cell Lymphoma, ALK-Positive; CD30-Positive Neoplastic Cells Present; Systemic Anaplastic Large Cell Lymphoma

 

Last Updated: 20 Apr 2018

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Brentuximab Vedotin and Imatinib in Patients With Relapsed or Refractory ALK+ ALCL
 

Status: Recruiting

Condition Summary: ALK+ Anaplastic Large Cell Lymphoma

 

Last Updated: 26 Jun 2017

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