Anaplastic oligodendroglioma

Common Name(s)

Anaplastic oligodendroglioma

Anaplastic oligodendroglioma is a rare form of brain cancer caused by tumors from oligodendrocytes. Oligodendrocytes is a type of cell that make up the supportive tissue (glial tissue) of the brain. Brain tumors are characterized by "grade" (grade I-IV) which is based on how normal or abnormal the tumor cells appear as well as how fast the tumor is growing. Anaplastic oligodendroglioma is a grade III tumor which means it is more likely to grow and spread quickly than a lower grade of tumor. Symptoms may include seizures, headaches, and personality changes. Other symptoms may vary depending on the location and size of the tumors including short-term memory loss, visual loss, motor weakness, and language problems. Because of the slow growth of these tumors, oligodendrogliomas may be present much earlier than it is diagnosed. Most cases of oligodendrolgliomas occur in adults ages 50-60 and is more common in males than females. Oligodendroglioma's are rare and only account for about 4% of all primary brain tumors. The exact cause is currently unknown however genetic changes may contribute to the development of these tumors. The main treatment for this type of cancer is a combination of chemotherapy and radiotherapy. Surgery may be required if the tumor is returns. Diagnoses may be done through a CT or MRI scan, however the main confirmation of the tumor is best done with a biopsy, in which the doctor removes a part or all of the tumor for examination. If you or a family member has been diagnosed with an anaplastic oligodendroglioma, talk with your doctors and specialists to learn about the most current treatment options available. Support groups are also a good source of information and may help you connect with others also affected by anaplastic oligodendrogliomas.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Anaplastic oligodendroglioma" for support, advocacy or research.

Accelerate Brain Cancer Cure

Our Mission: to invest in research aimed at finding the fastest possible route to a cure. We are focused on speeding the pace of research that will lead to new brain tumor therapies and, ultimately, a cure. We take an aggressive, venture funding approach not typically seen in the nonprofit sector. We have an enterprising attitude, we promote scientific collaboration and we're committed to measurable results.

Last Updated: 7 Jan 2013

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National Brain Tumor Society

National Brain Tumor Society is fiercely committed to finding better treatments, and ultimately a cure, for people living with a brain tumor today and anyone who will be diagnosed tomorrow. This means effecting change in the system at all levels. It’s time to build on progress and transform tomorrow, today.

Last Updated: 21 Nov 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Anaplastic oligodendroglioma" for support, advocacy or research.

Accelerate Brain Cancer Cure

Our Mission: to invest in research aimed at finding the fastest possible route to a cure. We are focused on speeding the pace of research that will lead to new brain tumor therapies and, ultimately, a cure. We take an aggressive, venture funding approach not typically seen in the nonprofit sector. We have an enterprising attitude, we promote scientific collaboration and we're committed to measurable results.

http://www.abc2.org

Last Updated: 7 Jan 2013

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National Brain Tumor Society

National Brain Tumor Society is fiercely committed to finding better treatments, and ultimately a cure, for people living with a brain tumor today and anyone who will be diagnosed tomorrow. This means effecting change in the system at all levels. It’s time to build on progress and transform tomorrow, today.

http://braintumor.org/

Last Updated: 21 Nov 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Anaplastic oligodendroglioma" returned 23 free, full-text research articles on human participants. First 3 results:

Multimodal F-Fluciclovine PET/MRI and Ultrasound-Guided Neurosurgery of an Anaplastic Oligodendroglioma.
 

Author(s): Anna Karlberg, Erik Magnus Berntsen, Håkon Johansen, Mariane Myrthue, Anne Jarstein Skjulsvik, Ingerid Reinertsen, Morteza Esmaeili, Hong Yan Dai, Yiming Xiao, Hassan Rivaz, Per Borghammer, Ole Solheim, Live Eikenes

Journal: World Neurosurg. 2017 Dec;108():989.e1-989.e8.

 

Structural magnetic resonance imaging (MRI) and histopathologic tissue sampling are routinely performed as part of the diagnostic workup for patients with glioma. Because of the heterogeneous nature of gliomas, there is a risk of undergrading caused by histopathologic sampling errors. ...

Last Updated: 31 Dec 1969

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Genetic landscape of extreme responders with anaplastic oligodendroglioma.
 

Author(s): Matthias Holdhoff, Gregory J Cairncross, Thomas M Kollmeyer, Ming Zhang, Peixin Zhang, Minesh P Mehta, Maria Werner-Wasik, Luis Souhami, Jean-Paul Bahary, Young Kwok, Alan C Hartford, Arnab Chakravarti, Srinivasan Yegnasubramanian, Bert Vogelstein, Nickolas Papadopoulos, Kenneth Kinzler, Robert B Jenkins, Chetan Bettegowda

Journal: Oncotarget. 2017 May;8(22):35523-35531.

 

The NRG Oncology RTOG 9402 trial showed significant survival benefit in patients with 1p/19q co-deleted anaplastic oligodendrogliomas (AO) who received both radiation (RT) and chemotherapy (PCV regimen) versus RT alone. Substantial separation of the survival curves was only seen after ...

Last Updated: 31 Dec 1969

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The Correlation Between 1p/19q Codeletion, IDH1 Mutation, p53 Overexpression and Their Prognostic Roles in 41 Turkish Anaplastic Oligodendroglioma Patients.
 

Author(s): Payam Hacisalihoglu, Zafer Kucukodaci, Gokcen Gundogdu, Bilge Bilgic

Journal: Turk Neurosurg. 2017 ;27(5):682-689.

 

To observe the correlation between 1p/19q codeletion, isocytrate dehydrogenase-1 (IDH1) mutation and p53 protein overexpression and their prognostic value in Turkish anaplastic oligodendroglioma patients who were treated with adjuvant radiotherapy and temozolomide chemotherapy.

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Anaplastic oligodendroglioma" returned 1 free, full-text review articles on human participants. First 3 results:

Occipital anaplastic oligodendroglioma with multiple organ metastases after a short clinical course: a case report and literature review.
 

Author(s): Gang Li, Zhiguo Zhang, Jianghong Zhang, Tianbo Jin, Hongjuan Liang, Li Gong, Guangbin Cui, Haixia Yang, Shiming He, Yongsheng Zhang, Guodong Gao

Journal:

 

It is generally believed that malignant gliomas never metastasize outside the central nervous system (CNS). However, the notion that oligodendrogliomas (OGDs) cells cannot spread outside CNS is being challenged.

Last Updated: 31 Dec 1969

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Carboplatin, Melphalan, Etoposide Phosphate, Mannitol, and Sodium Thiosulfate in Treating Patients With Previously Treated Brain Tumors
 

Status: Recruiting

Condition Summary: Adult Anaplastic Oligodendroglioma; Adult Mixed Glioma; Adult Oligodendroglioma; Oligoastrocytoma; Recurrent Adult Brain Neoplasm

 

Last Updated: 2 May 2018

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NovoTTF-200A Device in Treating Patients With Newly Diagnosed High Risk Oligodendroglioma
 

Status: Recruiting

Condition Summary: Anaplastic Oligodendroglioma; Oligoastrocytoma; Oligodendroglioma

 

Last Updated: 27 Mar 2018

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Last Updated: 29 May 2018

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