Castleman's Disease

Common Name(s)

Castleman's Disease, Angiofollicular ganglionic hyperplasia

Castleman’s disease is a lymphoproliferative disorder affecting the lymph nodes and related tissues. While the cause of Castleman's disease is unknown, many doctors suspect a virus is involved. Problems with the way an individual's immune system functions may also contribute to the development of the condition. There are 2 main forms of Castleman's disease: localized (discussed here) and multicentric. They affect people very differently. Localized or unicentric Castleman's disease only affects a single set of lymph nodes and is not widespread. The lymph nodes that are more commonly affected are in the chest and abdomen. Castleman’s disease causes the lymph nodes to get larger. The enlarged lymph nodes press on other organs and tissues inside the chest or abdomen, causing discomfort or difficulty breathing. Sometimes the enlarged lymph nodes are in places such as the neck, groin, or armpit and can be easily felt. People with localized Castleman's disease are often cured when the lymph node is removed with surgery. Chemotherapy and radiation may also be used. Please talk with your doctor about the most current treatment options if you or a family member has been diagnosed with Castleman's disease. See also Multicentric Castleman’s disease.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Castleman's Disease" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Castleman's Disease" returned 234 free, full-text research articles on human participants. First 3 results:

High proportion of TAFRO syndrome in Thai adult Castleman's disease patients: a 10-year experience.
 

Author(s): Weerapat Owattanapanich, Wikanda Pholmoo, Tawatchai Pongpruttipan, Noppadol Siritanaratkul

Journal: Ann. Hematol.. 2018 Jun;97(6):1019-1026.

 

Castleman's disease (CD) is a rare lymphoproliferative disorder, and its prevalence in Thailand is not known. This 10-year period study investigated the prevalence of CD in Thailand, and the clinical characteristics and outcomes of Thai CD patients, with special focus on the existence ...

Last Updated: 31 Dec 1969

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[Large B-cell lymphoma coexisting with Castleman's disease. Report of one case].
 

Author(s): Alejandro Avilés-Salas, Myrna Candelaria, Diana Brisa Sevilla-Lizcano, Sebastián Burgos

Journal: Rev Med Chil. 2017 Jul;145(7):945-949.

 

We report a 73-year-old female patient with Castleman's disease coexistent with large B cell type non-Hodgkin's lymphoma in a right axillary lymphadenopathy. An excisional biopsy was performed: microscopically, the lymph node revealed the presence of numerous plasma cells and small ...

Last Updated: 31 Dec 1969

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A patient with Castleman's disease mimicking acute pancreatitis.
 

Author(s): Jie Wu, Liang Lv, Chunlian Wang

Journal: Rev Esp Enferm Dig. 2017 Oct;109(10):737-738.

 

Castleman's disease is a rare event that gastroenterologists should be familiar with. We present a case of Castleman's disease presenting as acute pancreatitis. The diagnosis was established by excisional biopsy of a superficial lymph node and the patient had a favorable prognosis ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Castleman's Disease" returned 31 free, full-text review articles on human participants. First 3 results:

The role of surgical resection in Unicentric Castleman's disease: a systematic review.
 

Author(s): Sofoklis Mitsos, Alexandros Stamatopoulos, Davide Patrini, Robert S George, David R Lawrence, Nikolaos Panagiotopoulos

Journal: Adv Respir Med. 2018 ;86(1):36-43.

 

Castleman's disease is a rare benign lymphoproliferative disorder of unknown etiology. The disease occurs in two clinical forms with different prognoses, treatments and symptoms: a unicentric form (UCD), which is solitary, localized, and a multicentric form characterized by generalized ...

Last Updated: 31 Dec 1969

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Recurrence in unicentric castleman's disease postoperatively: a case report and literature review.
 

Author(s): Na Ren, Lei Ding, Erna Jia, Jinru Xue

Journal:

 

Our case describe a rare recurrence case of Unicentric Castleman's disease (UCD) with hyaline vascular type 14 years after surgery.

Last Updated: 31 Dec 1969

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Laparoscopic treatment of abdominal unicentric castleman's disease: a case report and literature review.
 

Author(s): Umberto Bracale, Francesco Pacelli, Marco Milone, Umberto Marcello Bracale, Maurizio Sodo, Giovanni Merola, Teresa Troiani, Enrico Di Salvo

Journal:

 

Castleman's disease is a rare lymphoproliferative disorder of unknown etiology that most commonly presents as a mediastinal nodal mass. It is exceptionally uncommon for Castleman's disease to present in the mesentery and, only 53 cases have ever been described in the literature. Standard ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Tocilizumab for KSHV-Associated Multicentric Castleman Disease
 

Status: Recruiting

Condition Summary: Castleman Disease; Castleman's Disease; Giant Lymph Node Hyperplasia

 

Last Updated: 18 Aug 2018

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TCP Regimen in Newly Diagnosed MCD:a Prospective, Single-center, Single-arm, Phase-II Pilot Trial
 

Status: Recruiting

Condition Summary: Multicentric Castleman Disease

 

Last Updated: 3 Feb 2017

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Unlock the Cell: Castleman's Disease Flow Cytometry Study
 

Status: Recruiting

Condition Summary: Castleman Disease; Angiofollicular Lymphoid Hyperplasia; GLNH; Hyperplasia; Castleman's Disease; Angiofollicular Lymph Hyperplasia; Giant Lymph Node Hyperplasia

 

Last Updated: 1 Aug 2018

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