Castleman's Disease

Common Name(s)

Castleman's Disease, Angiofollicular ganglionic hyperplasia

Castleman’s disease is a lymphoproliferative disorder affecting the lymph nodes and related tissues. While the cause of Castleman's disease is unknown, many doctors suspect a virus is involved. Problems with the way an individual's immune system functions may also contribute to the development of the condition. There are 2 main forms of Castleman's disease: localized (discussed here) and multicentric. They affect people very differently. Localized or unicentric Castleman's disease only affects a single set of lymph nodes and is not widespread. The lymph nodes that are more commonly affected are in the chest and abdomen. Castleman’s disease causes the lymph nodes to get larger. The enlarged lymph nodes press on other organs and tissues inside the chest or abdomen, causing discomfort or difficulty breathing. Sometimes the enlarged lymph nodes are in places such as the neck, groin, or armpit and can be easily felt. People with localized Castleman's disease are often cured when the lymph node is removed with surgery. Chemotherapy and radiation may also be used. Please talk with your doctor about the most current treatment options if you or a family member has been diagnosed with Castleman's disease. See also Multicentric Castleman’s disease.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Castleman's Disease" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Castleman's Disease" returned 238 free, full-text research articles on human participants. First 3 results:

Multicentric Castleman's disease in human immunodeficiency virus infection: two case reports.
 

Author(s): Amanda Caroline Ribeiro Sales, Valter Romão de Souza Junior, Marta Iglis de Oliveira, Claudia Azevedo Braga Albuquerque, Evônio de Barros Campelo Júnior, Paulo Sérgio Ramos de Araújo

Journal:

 

Castleman's Disease is a rare B-cell lymphoproliferative disease. It is mostly benign and is characterized by non-neoplastic lymph node hypertrophy, associated with infection by human herpesvirus-8 in people with the human immunodeficiency virus/acquired immunodeficiency syndrome. ...

Last Updated: 31 Dec 1969

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High proportion of TAFRO syndrome in Thai adult Castleman's disease patients: a 10-year experience.
 

Author(s): Weerapat Owattanapanich, Wikanda Pholmoo, Tawatchai Pongpruttipan, Noppadol Siritanaratkul

Journal: Ann. Hematol.. 2018 Jun;97(6):1019-1026.

 

Castleman's disease (CD) is a rare lymphoproliferative disorder, and its prevalence in Thailand is not known. This 10-year period study investigated the prevalence of CD in Thailand, and the clinical characteristics and outcomes of Thai CD patients, with special focus on the existence ...

Last Updated: 31 Dec 1969

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Hyaline vascular Castleman's disease representing 18 trisomy.
 

Author(s): Masaru Kojima, Seiichi Shimizu

Journal: J Clin Exp Hematop. 2018 03;58(1):36-38.

 

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Castleman's Disease" returned 32 free, full-text review articles on human participants. First 3 results:

The role of surgical resection in Unicentric Castleman's disease: a systematic review.
 

Author(s): Sofoklis Mitsos, Alexandros Stamatopoulos, Davide Patrini, Robert S George, David R Lawrence, Nikolaos Panagiotopoulos

Journal: Adv Respir Med. 2018 ;86(1):36-43.

 

Castleman's disease is a rare benign lymphoproliferative disorder of unknown etiology. The disease occurs in two clinical forms with different prognoses, treatments and symptoms: a unicentric form (UCD), which is solitary, localized, and a multicentric form characterized by generalized ...

Last Updated: 31 Dec 1969

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Recurrence in unicentric castleman's disease postoperatively: a case report and literature review.
 

Author(s): Na Ren, Lei Ding, Erna Jia, Jinru Xue

Journal:

 

Our case describe a rare recurrence case of Unicentric Castleman's disease (UCD) with hyaline vascular type 14 years after surgery.

Last Updated: 31 Dec 1969

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Castleman's Disease: A Rare Mass in the Pararenal Retroperitoneum that Mimics Other Tumors.
 

Author(s): Yi Xie, Yi Zhao, Zhi-Gang Ji, Han-Zhong Li, Guang-Hua Liu, Quan-Zhong Mao

Journal: Chin. Med. J.. 2017 09;130(17):2126-2127.

 

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Tocilizumab for KSHV-Associated Multicentric Castleman Disease
 

Status: Recruiting

Condition Summary: Castleman Disease; Castleman's Disease; Giant Lymph Node Hyperplasia

 

Last Updated: 18 Aug 2018

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TCP Regimen in Newly Diagnosed MCD:a Prospective, Single-center, Single-arm, Phase-II Pilot Trial
 

Status: Recruiting

Condition Summary: Multicentric Castleman Disease

 

Last Updated: 3 Feb 2017

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Unlock the Cell: Castleman's Disease Flow Cytometry Study
 

Status: Recruiting

Condition Summary: Castleman Disease; Angiofollicular Lymphoid Hyperplasia; GLNH; Hyperplasia; Castleman's Disease; Angiofollicular Lymph Hyperplasia; Giant Lymph Node Hyperplasia

 

Last Updated: 1 Aug 2018

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