Antisynthetase Syndrome

Common Name(s)

Antisynthetase Syndrome

Antisynthetase syndrome is a chronic autoimmune disease of unknown cause. It is a subgroup of the idiopathic (unknown cause) inflammatory muscle diseases and is characterized by myositis, interstitial lung disease, arthritis, and Raynaud's phenomenon.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Antisynthetase Syndrome" for support, advocacy or research.

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General Resources

Antisynthetase Syndrome

Antisynthetase Syndrome (ASS) includes myositis, Interstitial Lung Disease, Raynaud’s Phenomenon, Inflammatory Polyarthritis, Mechanic’s hands and Fever. Jo1 antibody is associated in a large number of cases.

Updated 3 Mar 2018

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Antisynthetase Syndrome" returned 43 free, full-text research articles on human participants. First 3 results:

Skeletal Muscle Involvement in Antisynthetase Syndrome.
 

Author(s): Eri Noguchi, Akinori Uruha, Shigeaki Suzuki, Kohei Hamanaka, Yuko Ohnuki, Jun Tsugawa, Yurika Watanabe, Jin Nakahara, Takashi Shiina, Norihiro Suzuki, Ichizo Nishino

Journal: JAMA Neurol. 2017 Aug;74(8):992-999.

 

Antisynthetase syndrome, characterized by myositis, interstitial lung disease, skin rash, arthropathy, and Raynaud phenomenon, is a clinical entity based on the presence of aminoacyl transfer RNA synthetase (ARS) antibodies in patients' serum. However, antisynthetase syndrome is not ...

Last Updated: 31 Dec 1969

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A Rare Case of Necrotizing Myopathy and Fibrinous and Organizing Pneumonia with Anti-EJ Antisynthetase Syndrome and SSA Antibodies.
 

Author(s): Muhammad Kashif, Divya Arya, Masooma Niazi, Misbahuddin Khaja

Journal:

 

BACKGROUND Idiopathic inflammatory myopathies are autoimmune disorders that can involve the skin, joints, muscles, and lungs. The most common of these disorders are dermatomyositis, polymyositis, overlap syndrome, and inclusion body myositis. Necrotizing autoimmune myopathy is an ...

Last Updated: 31 Dec 1969

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Subcutaneous immunoglobulins for the treatment of a patient with antisynthetase syndrome and secondary chronic immunodeficiency after anti-CD20 treatment: a case report.
 

Author(s): Patrick Cherin, Christophe de Jaeger, Jean-Charles Crave, Jean-Christophe Delain, Abir Tadmouri, Zahir Amoura

Journal:

 

Antisynthetase syndrome is a rare and debilitating multiorgan disease characterized by inflammatory myopathy, interstitial lung disease, cutaneous involvement, and frequent chronic inflammation of the joints. Standard treatments include corticosteroids and immunosuppressants. In some ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Antisynthetase Syndrome" returned 4 free, full-text review articles on human participants. First 3 results:

[Pulmonary manifestations of antisynthetase syndrome].
 

Author(s): S Jouneau, B Hervier, E-M Jutant, O Decaux, M Kambouchner, M Humbert, P Delaval, D Montani

Journal: Rev Mal Respir. 2015 Jun;32(6):618-28.

 

Antisynthetase syndrome is an inflammatory myopathy frequently associated with pulmonary manifestations, especially interstitial lung diseases, and uncommonly pulmonary hypertension. In the context of a suggestive clinical and radiological picture, positive anti-RNA synthetase antibodies ...

Last Updated: 31 Dec 1969

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Antisynthetase Syndrome: two case report and literature review.
 

Author(s): Lívia Regina Theilacker, Fabíola Sampaio Brandão, Fernanda Velloso Goulart, João Luiz Pereira Vaz, Luiz Octávio Dias D'Almeida, Maria Cecília da Fonseca Salgado

Journal: Rev Bras Reumatol. ;55(2):177-80.

 

Antissintetase Syndrome (ASS) is characterized by myositis, Raunaud's phenomenon, fever, intertitial lung disease, mechanic's hands and arthropathy associated with the presence of antibodies against tRNA synthetase, especially anti-Jo-1. This article aims to review the literature ...

Last Updated: 31 Dec 1969

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Anti-PL-7 (anti-threonyl-tRNA synthetase) antisynthetase syndrome: clinical manifestations in a series of patients from a European multicenter study (EUMYONET) and review of the literature.
 

Author(s): Ane Labirua-Iturburu, Albert Selva-O'Callaghan, Melinda Vincze, Katalin Dankó, Jiri Vencovsky, Benjamin Fisher, Peter Charles, Maryam Dastmalchi, Ingrid E Lundberg

Journal: Medicine (Baltimore). 2012 Jul;91(4):206-11.

 

Autoantibodies against several aminoacyl-transfer-RNA synthetases have been described in patients with myositis; anti-threonyl-tRNA synthetase (anti-PL-7) is one of the rarest. We describe the clinical and laboratory characteristics of a cohort of European anti-PL-7 patients, and ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Environmental Risk Factors for the Anti-synthetase Syndrome
 

Status: Recruiting

Condition Summary: Myositis; Dermatomyositis; Polymyositis; Juvenile Dermatomyositis; Juvenile Polymyositis

 

Last Updated: 8 Aug 2018

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Abatacept for the Treatment of Myositis-associated Interstitial Lung Disease
 

Status: Recruiting

Condition Summary: Myositis; Interstitial Lung Disease

 

Last Updated: 9 Oct 2017

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Optimizing Treatment on Idiopathic Inflammatory Myopathies
 

Status: Recruiting

Condition Summary: Idiopathic Inflammatory Myopathies

 

Last Updated: 9 May 2018

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