Antithrombin III Deficiency

Common Name(s)

Antithrombin III Deficiency

Deficiency of antithrombin III is a major risk factor for venous thromboembolic disease. Two categories of AT-III deficiency have been defined on the basis of AT-III antigen levels in the plasma of affected individuals. The majority of AT-III deficiency families belong in the type I (classic) deficiency group and have a quantitatively abnormal phenotype in which antigen and heparin cofactor levels are both reduced to about 50% of normal. The second category of AT-III deficiency has been termed type II (functional) deficiency. Affected individuals from these kindreds produce dysfunctional AT-III molecules; they have reduced heparin cofactor activity levels (about 50% of normal) but levels of AT-III antigen are often normal or nearly normal (summary by {5:Bock and Prochownik, 1987}). The 2 categories of antithrombmin III deficiency have been classified further. Type I (low functional and immunologic antithrombin) has been subdivided into subtype Ia (reduced levels of normal antithrombin), and type Ib (reduced levels of antithrombin and the presence of low levels of a variant). Type II (low functional but normal immunologic antithrombin) has been subdivided into subtype IIa (functional abnormalities affecting both the reactive site and the heparin-binding site of AT3); subtype IIb (functional abnormalities limited to the reactive site); and subtype IIc (functional abnormalities limited to the heparin-binding site) (summary by {15:Lane et al., 1992}).
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Antithrombin III Deficiency" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Antithrombin III Deficiency" returned 40 free, full-text research articles on human participants. First 3 results:

Familial antithrombin III deficiency in a Malay patient with massive thrombosis.
 

Author(s): W S Wan Ab Rahman, W Z Abdullah, M N Hassan, A Hussin, Z Zulkafli, J Haron

Journal: Malays J Pathol. 2017 Aug;39(2):197-200.

 

Patients with low antithrombin III (AT III) has increased risk for arteriovenous thromboembolic (TE) disease. We report a 28-year-old Malay lady who presented with spontaneous right calf pain and swelling of one week duration. She was on oral contraceptive pills and had a history ...

Last Updated: 31 Dec 1969

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Antithrombin III deficiency concomitant with atrial fibrillation causes thrombi in all chambers: 2D and 3D echocardiographic evaluation.
 

Author(s): Mert İlker Hayıroğlu, Muhammed Keskin, Cevdet Dönmez, Muhammed Burak Günay, Şennur Ünal Dayı

Journal: Anatol J Cardiol. 2016 12;16(12):E21-E22.

 

Last Updated: 31 Dec 1969

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Edoxaban Was Effective for the Treatment of Deep Vein Thrombosis and Pulmonary Thromboembolism in a Cancer Patient with Antithrombin III Deficiency.
 

Author(s): Hiroaki Kawano, Koji Maemura

Journal: Intern. Med.. ;55(22):3285-3289.

 

A 57-year-old man with antithrombin III deficiency with deep vein thrombosis and pulmonary thromboembolism after surgery for colon cancer was managed with warfarin and inferior vena cava filtration. After starting chemotherapy for liver metastasis, the control of his prothrombin time-international ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Antithrombin III Deficiency" returned 2 free, full-text review articles on human participants. First 3 results:

Plasma antithrombin III deficiency in ischaemic stroke in the young.
 

Author(s): D Nagaraja, R Christopher, M Tripathi

Journal: Neurol India. 1999 Jun;47(2):155-6.

 

A deficiency of plasma antithrombin III has been identified as a potential risk factor for thrombosis. In a pilot study of 56 patients aged less than 40 years who presented with ischaemic stroke of unknown etiology, we detected only one case of plasma antithrombin III deficiency. ...

Last Updated: 31 Dec 1969

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Catastrophic secondary antiphospholipid syndrome with concomitant antithrombin III deficiency.
 

Author(s): V R Peddi, K S Kant

Journal: J. Am. Soc. Nephrol.. 1995 May;5(11):1882-7.

 

The association between thrombotic events and primary or secondary antiphospholipid/anticardiolipin syndrome is now well recognized. A spectrum of renal involvement ranging from glomerular thrombosis to renal infarction has been described. A case of systemic lupus erythematosus with ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

"Incidence and Consequences of Disorders of Glycosylation in Patients With Conotruncal and Septal Heart Defects"
 

Status: Recruiting

Condition Summary: Congenital Heart Diseases; Conotruncal Defects; Congenital Disorder of Glycosylation; Antithrombin III Deficiency

 

Last Updated: 24 Mar 2017

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