Idiopathic basal ganglia calcification (IBGC) 3, is a rare disorder that causes abnormal deposits of calcium in the brain, specifically the basal ganglia. Calcium is a mineral in the body that is important for the body to function properly. The basal ganglia helps control movement of the body and is involved in learning, cognition, and emotion. Individuals affected with IBGC may have movement, psychiatric, or behavioral disorders. The disease normally begins between 30 and 50 years old. Symptoms involving movement include loss of motor control, uncontrollable shaking, and wild movements of the limbs. Other symptoms include memory loss, difficulty concentrating, changes in personality, abnormal perceptions of reality, and intellectual decline (dementia). Individuals also suffer from seizures and chronic headaches. The symptoms depend on where in the basal ganglia the calcium is deposited and how much is there.
Idiopathic basal ganglia calcification 3, is a genetic condition caused by a change in the SLC20A2 gene. IBGC is passed down from parent to child in an autosomal dominant manner which means only one mutation from one parent is needed to cause symptoms. A person with this condition has a 50/50 chance of passing the condition on to their children. Diagnosis is achieved by brain imaging techniques to see the basal ganglia. Also genetic tests can determine if the disorder is present by looking for mutations in the SLC20A2 gene.
There is currently no treatment to cure the disorder but treatments are available to help with symptoms. If you or a family member has been diagnosed with Idiopathic basal ganglia calcification 3, talk with your doctor about the most current treatment options. Support groups are also good resources for support and information.
Description Last Updated: Feb 13, 2018