(frequently called IgA nephropathy) is a kidney disorder that occurs when IgA, a protein that helps the body fight infections, settles in the kidneys. The cause of this condition is unknown. After many years, deposits of IgA may cause the kidneys to leak blood and sometimes protein in the urine. In the early stages, Berger disease has no symptoms. The first sign of this condition may be blood in the urine. After 10 to 20 years with Berger disease, the kidneys may show signs of damage. Treatment focuses on slowing the disease and preventing complications.
Berger disease can occur at any age, even in childhood. About 25 percent of adults and 5 to 10 percent of children with Berger disease develop total kidney failure. Total kidney failure means the kidney damage is permanent and dialysis or a kidney transplant is required. Source: Genetic and Rare Diseases Information Center (GARD), supported by ORDR-NCATS and NHGRI.