Blood group--Kell system

Common Name(s)

Blood group--Kell system

The Kell blood group system is formed by 2 disulfide-linked proteins, Kell and XK. The Kell protein is a type II membrane glycoprotein sharing sequence homology with members of the M13 family of zinc-dependent metalloproteases and possessing enzymatic activity characteristic of that group (summary by {2:Claperon et al., 2007}). The Kell blood group system is highly polymorphic, expressing over 25 antigens that have been classified in to 5 antithetical sets of high and low prevalence antigens with the others being independently expressed or having unknown antithetical partners. The different phenotypes are due to single-nucleotide mutations that result in an amino acid substitution (summary by {10:Sha et al., 2006}). See, for example, Kell (designated K or K1)/Cellano (k, K2) (T193M; {613883.0001}). {15:Yu et al. (2001)} noted that the Kell antigens are the most potent immunogens aside from the A and B antigens of the ABO system ({616093}) and the D antigen ({111680}) of the Rh system (see {111700}).
 

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