Botulism

Common Name(s)

Botulism

Botulism is a disease caused by the bacteria Clostridium botulinum. There are three main types: infant botulism, foodbourne botulism, and wound botulism. All types are very serious and can be fatal. Each type of botulism has different symptoms, but all include muscle weakness, paralysis, and drooping of the eyes. For all cases, direct contact or ingestion of the bacteria causes the disease. There is an antitoxin available for early prevention of botulism that stops further harm by the infection. For foodborne infections, doctors may induce vomiting and bowel movements to force the bacteria out of your system.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Botulism" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Botulism" returned 220 free, full-text research articles on human participants. First 3 results:

Effective and rapid treatment of wound botulism, a case report.
 

Author(s): M Schulte, U Hamsen, T A Schildhauer, T Ramczykowski

Journal:

 

The latest news shows several cases of contaminated heroin that is found in different parts all over Europe. This information can be helpful for the emergency doctors to find the correct diagnosis of wound botulism in patients who are intravenous drug users.

Last Updated: 31 Dec 1969

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Takotsubo-like Myocardial Dysfunction in a Patient with Botulism.
 

Author(s): Shuichi Tonomura, Yoshiaki Kakehi, Masatoshi Sato, Yuki Naito, Hisao Shimizu, Yasunobu Goto, Nobuyuki Takahashi

Journal: Intern. Med.. 2017 Nov;56(21):2925-2927.

 

Botulinum toxin A (BTXA) can disrupt the neuromuscular and autonomic functions. We herein report a case of autonomic system dysfunction that manifested as Takotsubo-like myocardial dysfunction in a patient with botulism. Takotsubo syndrome results in acute cardiac insufficiency, another ...

Last Updated: 31 Dec 1969

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A childhood-onset intestinal toxemia botulism during chemotherapy for relapsed acute leukemia.
 

Author(s): Noriko Ohyama, Michiko Torio, Kentaro Nakashima, Yuuki Koga, Shunsuke Kanno, Hisanori Nishio, Kei Nishiyama, Momoko Sasazuki, Haru Kato, Hiroshi Asakura, Satoshi Akamine, Masafumi Sanefuji, Yoshito Ishizaki, Yasunari Sakai, Shouichi Ohga

Journal:

 

Botulism is a potentially fatal infection characterized by progressive muscle weakness, bulbar paralysis, constipation and other autonomic dysfunctions. A recent report suggested that cancer chemotherapy might increase the risk for the intestinal toxemia botulism in both adults and children.

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Botulism" returned 15 free, full-text review articles on human participants. First 3 results:

Vaccines against Botulism.
 

Author(s): Grace Sundeen, Joseph T Barbieri

Journal:

 

Botulinum neurotoxins (BoNT) cause the flaccid paralysis of botulism by inhibiting the release of acetylcholine from motor neurons. There are seven serotypes of BoNT (A-G), with limited therapies, and no FDA approved vaccine for botulism. An investigational formalin-inactivated penta-serotype-BoNT/A-E ...

Last Updated: 31 Dec 1969

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Cargo-delivery platforms for targeted delivery of inhibitor cargos against botulism.
 

Author(s): Brenda A Wilson, Mengfei Ho

Journal: Curr Top Med Chem. 2014 ;14(18):2081-93.

 

Delivering therapeutic cargos to specific cell types in vivo poses many technical challenges. There is currently a plethora of drug leads and therapies against numerous diseases, ranging from small molecule compounds to nucleic acids to peptides to proteins with varying binding or ...

Last Updated: 31 Dec 1969

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Botulinum neurotoxins and botulism: a novel therapeutic approach.
 

Author(s): Jeeraphong Thanongsaksrikul, Wanpen Chaicumpa

Journal: Toxins (Basel). 2011 05;3(5):469-88.

 

Specific treatment is not available for human botulism. Current remedial mainstay is the passive administration of polyclonal antibody to botulinum neurotoxin (BoNT) derived from heterologous species (immunized animal or mouse hybridoma) together with supportive and symptomatic management. ...

Last Updated: 31 Dec 1969

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.