Calcium pyrophosphate deposition disease (CPDD)

Calcium pyrophosphate deposition disease (CPDD) (also known as chondrocalcinosis, pseudogout, or pyrophosphate arthopathy) is a joint disorder caused by the accumulation of calcium pyrophosphate dihydrate (CPPD) crystals in the joints and surrounding tissues. These crystals cause inflammation in the joint which causes the surrounding connective tissue, cartilage, to break down. The knee joint is the most commonly affected area and is more common in older adults, although CPDD can occur at any joint. People with CPDD may experience no symptoms. However when there are symptoms, the condition may present in one of several ways. About half of people experience pseudoarthritis which is characterized by progressive (worsening) degeneration of multiple joints. Over time the joints may become deformed. About twenty-five percent present as pseudogout with sudden onset of intense and constant pain in one joint which lasts for several days to two weeks. The knee is the most commonly involved joint, though it can occur anywhere and fever may be present as well. A small portion present as pseudorheumatoid arthritis with less intense pain, morning stiffness and fatique. It often occurs in symmetrical joints meaning the same joint on both sides of the body (both elbows or both knees for example). In all forms, women and men are equally affected and the frequency increases with age. There is currently no cure for this condition, but there are a variety of medications the individual can take for pain management including corticosteroids and anti-inflammatory drugs. CPDD is diagnosed through a joint fluid examination or an x-ray. If you or a family member has been diagnosed with CPDD, please talk with your doctor about the most current treatment options.