Developmental delay

Common Name(s)

Developmental delay

Developmental delay is a lag in one or more areas of development for a child. The major areas of childhood development include cognitive (intelligence and ability to process information), social and emotional (ability to interact with and appropriately respond to others), speech and language (ability to speak and understand language), fine motor (small movements), and gross motor (large movements). Children can have a delay in only one area of development, such as speech delay, or can have delay in all areas of development, called global developmental delay. It is important to keep in mind that there is a large range of normal development and each child develops at his or her own pace. However, any concern for development delay should be addressed.

Developmental delay can be caused by any number of inherited or acquired reasons, including an underlying genetic condition or metabolic disorder (Down syndrome, Fragile X syndrome, or phenylketonuria (PKU)), autism spectrum disorder, exposure to harmful agents before a baby is born (prenatal alcohol exposure, prenatal drug exposure, prenatal infection or poor maternal nutrition), and premature birth. Developmental delay is identified and diagnosed through developmental screenings and evaluations that are typically performed by a doctor or a specialist, such as a neuropsychologist. Treatment of developmental delay typically consists of therapies that focus on the area, or areas, of delay. Children with delays in language development typically receive speech therapy. Children with delays in fine motor development typically receive occupational therapy. Children with delays in gross motor development typically receive physical therapy. If an underlying treatable condition is identified as the reason for developmental delay, treatment of that condition may help improve development. Speak to your doctor about the best treatment options for your child.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Developmental delay" for support, advocacy or research.

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Simons VIP Connect

The Simons Variation in Individuals Project (Simons VIP) is an online community and research initiative. We provide a platform to partner families and researchers to better understand over 40 genetic changes (genomic variants) associated with features related to autism and developmental delay.

Last Updated: 20 Jul 2015

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Developmental delay" for support, advocacy or research.

Logo
Simons VIP Connect

The Simons Variation in Individuals Project (Simons VIP) is an online community and research initiative. We provide a platform to partner families and researchers to better understand over 40 genetic changes (genomic variants) associated with features related to autism and developmental delay.

http://www.simonsvipconnect.org

Last Updated: 20 Jul 2015

View Details

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Developmental delay" returned 268 free, full-text research articles on human participants. First 3 results:

Molecular diagnosis of patients with epilepsy and developmental delay using a customized panel of epilepsy genes.
 

Author(s): Laura Ortega-Moreno, Beatriz G Giráldez, Victor Soto-Insuga, Rebeca Losada-Del Pozo, María Rodrigo-Moreno, Cristina Alarcón-Morcillo, Gema Sánchez-Martín, Esther Díaz-Gómez, Rosa Guerrero-López, José M Serratosa,

Journal:

 

Pediatric epilepsies are a group of disorders with a broad phenotypic spectrum that are associated with great genetic heterogeneity, thus making sequential single-gene testing an impractical basis for diagnostic strategy. The advent of next-generation sequencing has increased the ...

Last Updated: 31 Dec 1969

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De novo variants in are associated with hypotonia, developmental delay, intellectual disability, and autism.
 

Author(s): Akemi J Tanaka, Megan T Cho, Rebecca Willaert, Kyle Retterer, Yuri A Zarate, Katie Bosanko, Vikki Stefans, Kimihiko Oishi, Amy Williamson, Golder N Wilson, Alice Basinger, Tina Barbaro-Dieber, Lucia Ortega, Susanna Sorrentino, Melissa K Gabriel, Ilse J Anderson, Maria J Guillen Sacoto, Rhonda E Schnur, Wendy K Chung

Journal:

 

Using whole-exome sequencing, we identified seven unrelated individuals with global developmental delay, hypotonia, dysmorphic facial features, and an increased frequency of short stature, ataxia, and autism with de novo heterozygous frameshift, nonsense, splice, and missense variants ...

Last Updated: 31 Dec 1969

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Mutations in GPAA1, Encoding a GPI Transamidase Complex Protein, Cause Developmental Delay, Epilepsy, Cerebellar Atrophy, and Osteopenia.
 

Author(s): Thi Tuyet Mai Nguyen, Yoshiko Murakami, Eamonn Sheridan, Sophie Ehresmann, Justine Rousseau, Anik St-Denis, Guoliang Chai, Norbert F Ajeawung, Laura Fairbrother, Tyler Reimschisel, Alexandra Bateman, Elizabeth Berry-Kravis, Fan Xia, Jessica Tardif, David A Parry, Clare V Logan, Christine Diggle, Christopher P Bennett, Louise Hattingh, Jill A Rosenfeld, Michael Scott Perry, Michael J Parker, Françoise Le Deist, Maha S Zaki, Erika Ignatius, Pirjo Isohanni, Tuula Lönnqvist, Christopher J Carroll, Colin A Johnson, Joseph G Gleeson, Taroh Kinoshita, Philippe M Campeau

Journal: Am. J. Hum. Genet.. 2017 Nov;101(5):856-865.

 

Approximately one in every 200 mammalian proteins is anchored to the cell membrane through a glycosylphosphatidylinositol (GPI) anchor. These proteins play important roles notably in neurological development and function. To date, more than 20 genes have been implicated in the biogenesis ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Developmental delay" returned 20 free, full-text review articles on human participants. First 3 results:

Current evidence-based recommendations on investigating children with global developmental delay.
 

Author(s): Renuka Mithyantha, Rachel Kneen, Emma McCann, Melissa Gladstone

Journal: Arch. Dis. Child.. 2017 11;102(11):1071-1076.

 

Global developmental delay (GDD) affects 1%-3% of the population of children under 5 years of age, making it one of the most common conditions presenting in paediatric clinics; causes are exogenous, genetic (non-metabolic) or genetic (metabolic). Recent advances in biotechnology ...

Last Updated: 31 Dec 1969

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Exome sequencing identifies a de novo mutation of CTNNB1 gene in a patient mainly presented with retinal detachment, lens and vitreous opacities, microcephaly, and developmental delay: Case report and literature review.
 

Author(s): Niu Li, Yufei Xu, Guoqiang Li, Tingting Yu, Ru-En Yao, Xiumin Wang, Jian Wang

Journal: Medicine (Baltimore). 2017 May;96(20):e6914.

 

The CTNNB1 (β-catenin) gene is well known for its crucial role in cell adhesion and the Wnt-signaling pathway. Previous studies have shown that gain-of-function mutations in the CTNNB1 gene contribute to the occurrence and development of a variety of carcinomas in humans. Recently, ...

Last Updated: 31 Dec 1969

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Recommendations on screening for developmental delay.
 

Author(s): Marcello Tonelli, Patricia Parkin, Paula Brauer, Denis Leduc, Kevin Pottie, Alejandra Jaramillo Garcia, Wendy Martin, Sarah Connor Gorber, Anne-Marie Ugnat, Marianna Ofner, Brett D. Thombs,

Journal: CMAJ. 2016 05;188(8):579-87.

 

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Effects of Insoles on Children With Developmental Delays
 

Status: Not yet recruiting

Condition Summary: Developmental Delay

 

Last Updated: 22 Jun 2017

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Last Updated: 15 Aug 2017

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Effects of Family Work Shop for Children With Developmental Delays: a Randomized Trial
 

Status: Not yet recruiting

Condition Summary: Development Delay

 

Last Updated: 4 Jul 2017

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