Dominant Cleft Palate

Common Name(s)

Dominant Cleft Palate

Description for this condition is not yet available.
 

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Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Dominant Cleft Palate" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Dominant Cleft Palate" returned 6 free, full-text research articles on human participants. First 3 results:

Irf6 directly regulates Klf17 in zebrafish periderm and Klf4 in murine oral epithelium, and dominant-negative KLF4 variants are present in patients with cleft lip and palate.
 

Author(s): Huan Liu, Elizabeth J Leslie, Zhonglin Jia, Tiffany Smith, Mekonen Eshete, Azeez Butali, Martine Dunnwald, Jeffrey Murray, Robert A Cornell

Journal: Hum. Mol. Genet.. 2016 Feb;25(4):766-76.

 

Non-syndromic (NS) cleft lip with or without cleft palate (CL/P) is a common disorder with a strong genetic underpinning. Genome-wide association studies have detected common variants associated with this disorder, but a large portion of the genetic risk for NSCL/P is conferred by ...

Last Updated: 31 Dec 1969

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Autosomal dominant nonsyndromic cleft lip and palate: significant evidence of linkage at 18q21.1.
 

Author(s): Soraya Beiraghi, Swapan K Nath, Matthew Gaines, Desh D Mandhyan, David Hutchings, Uppala Ratnamala, Ken McElreavey, Lucia Bartoloni, Gregory S Antonarakis, Stylianos E Antonarakis, Uppala Radhakrishna

Journal: Am. J. Hum. Genet.. 2007 Jul;81(1):180-8.

 

Nonsyndromic cleft lip with or without cleft palate (NSCL/P) is one of the most common congenital facial defects, with an incidence of 1 in 700-1,000 live births among individuals of European descent. Several linkage and association studies of NSCL/P have suggested numerous candidate ...

Last Updated: 31 Dec 1969

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No evidence of linkage between the transforming growth factor-alpha gene in families with apparently autosomal dominant inheritance of cleft lip and palate.
 

Author(s): G M Vintiner, S E Holder, R M Winter, S Malcolm

Journal: J. Med. Genet.. 1992 Jun;29(6):393-7.

 

Eight families have been identified with cleft lip, with or without cleft palate (CL/P), inherited in an apparently autosomal dominant manner. Transforming growth factor-alpha (TGFA) has been tested as a candidate gene for clefting in these families. Negative lod scores were generated ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Dominant Cleft Palate" returned 0 free, full-text review articles on human participants.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.