Drug-induced Parkinsonism

Common Name(s)

Drug-induced Parkinsonism

Drug-induced Parkinsonism is, as the name indicates, the result of developing parkinsonism and its symptoms following treatment with particular medications. Drug-induced Parkinsonism accounts for about 7% of people with parkinsonism. People with spontaneous or unknown cause of Parkinson’s disease and other causes of parkinsonism may also develop worsening symptoms if treated with such medication accidentally.

Any drug that blocks the action of dopamine (referred to as a dopamine antagonist) is likely to cause parkinsonism. Drugs used to treat schizophrenia and other psychotic disorders such as behavior disturbances in people with dementia (known as neuroleptic drugs) are possibly the major cause of drug-induced parkinsonism worldwide. Parkinsonism can occur from the use of any of the various classes of neuroleptics.

The atypical neuroleptics – clozapine (Clozaril) and quetiapine (Seroquel), and to a lesser extent olanzapine (Zyprexa) and risperidone (Risperdal) – appear to have a lower incidence of extrapyramidal side effects, including parkinsonism. These drugs are generally best avoided by people with Parkinson’s, although some may be used by specialists to treat symptoms such as hallucinations occurring with Parkinson’s. Risperidone and olanzapine should be used with caution to treat dementia in people at risk of stroke (the risk increases with age, hypertension, diabetes, atrial fibrillation, smoking and high cholesterol), because of an increased risk of stroke and other cerebrovascular problems. It is unclear whether there is an increased risk of stroke with quetiapine and clozapine.

Drug-induced parkinsonism is more likely to be symmetrical (on both sides of the body) and less likely to be associated with tremor, although it can sometimes present asymmetrically and with a tremor.

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Condition Specific Organizations

Following organizations serve the condition "Drug-induced Parkinsonism" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Drug-induced Parkinsonism" returned 14 free, full-text research articles on human participants. First 3 results:

Incidence and time trends of drug-induced parkinsonism: A 30-year population-based study.
 

Author(s): Rodolfo Savica, Brandon R Grossardt, James H Bower, J Eric Ahlskog, Michelle M Mielke, Walter A Rocca

Journal: Mov. Disord.. 2017 Feb;32(2):227-234.

 

Epidemiological studies of drug-induced parkinsonism remain limited.

Last Updated: 31 Dec 1969

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Persistent Drug-Induced Parkinsonism in Patients with Normal Dopamine Transporter Imaging.
 

Author(s): Jin Yong Hong, Mun Kyung Sunwoo, Jungsu S Oh, Jae Seung Kim, Young H Sohn, Phil Hyu Lee

Journal:

 

Functional neuroimaging for the dopamine transporter (DAT) is used to distinguish drug-induced parkinsonism (DIP) from subclinical Parkinson's disease (PD). Although DIP patients who show a normal DAT image are expected to recover completely, some do not. We investigated whether these ...

Last Updated: 31 Dec 1969

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Cognitive Dysfunction in Drug-induced Parkinsonism Caused by Prokinetics and Antiemetics.
 

Author(s): Hyun Jung Ahn, Woo-Kyoung Yoo, Jaeseol Park, Hyeo-Il Ma, Yun Joong Kim

Journal: J. Korean Med. Sci.. 2015 Sep;30(9):1328-33.

 

The use of prokinetics/antiemetics is one of the leading causes of drug-induced parkinsonism (DIP) observed in neurology clinics. Cognitive dysfunction in DIP has recently been recognized, but pathologies related with cognitive dysfunction is unknown. Among our retrospective cohort ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Drug-induced Parkinsonism" returned 1 free, full-text review articles on human participants. First 3 results:

Differentiating drug-induced parkinsonism from Parkinson's disease: an update on non-motor symptoms and investigations.
 

Author(s): Francesco Brigo, Roberto Erro, Antonio Marangi, Kailash Bhatia, Michele Tinazzi

Journal: Parkinsonism Relat. Disord.. 2014 Aug;20(8):808-14.

 

Drug-induced parkinsonism is the second most common cause of parkinsonism after Parkinson's disease and their distinction has crucial implications in terms of management and prognosis. However, differentiating between these conditions can be challenging on a clinical ground, especially ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Effect of Exercise in Parkinsonism
 

Status: Recruiting

Condition Summary: Parkinson's Disease; Drug-induced Parkinsonism

 

Last Updated: 9 Mar 2018

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Degenerative Nigrostriatal Dysfunction in Drug-induced Parkinsonism
 

Status: Recruiting

Condition Summary: Secondary Parkinsonism; Parkinson's Disease

 

Last Updated: 3 Apr 2018

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Biomarkers in Neural Disorders
 

Status: Recruiting

Condition Summary: Parkinson's Disease; Alzheimer's Disease; Progressive Supranuclear Palsy; Essential Tremor; Multiple System Atrophy; Drug Induced Parkinson's Disease; Diffuse Lewy Body Disease; Myasthenia Gravis; Spinal Cord Injuries

 

Last Updated: 7 Sep 2017

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