Dry Age-related macular degeneration

Common Name(s)

Dry Age-related macular degeneration

Dry macular degeneration, also known as atrophic macular degeneration, is a form of age-related macular degeneration (AMD) which causes vision loss that gets worse over time (progressive). The macula is located in the central part of the back of the eye (retina) and helps a person see fine details and perform tasks such as reading and driving (sharp central vision). All forms of AMD cause damage to the macula, which is the reason for the vision loss. In dry macular degeneration, deposits of waste products from the cells (drusen) build up on the retina and cause the layers of the macula to become thin (atrophy), which leads to blurred vision. In some cases, the drusen may not affect vision, but will change the color (pigmentation) of the macula.

The vision loss caused by dry macular degeneration usually affects only the center of the eye, so affected individuals can usually still recognize objects on the edges of their vision (peripheral vision). About 90 percent of all AMD cases are the dry form. Some cases of dry macular degeneration develop into wet macular degeneration, which leads to rapid and severe loss of vision.

The cause of dry macular degeneration is unclear. Age and genetics are the two most significant risk factors. Dry macular degeneration is usually found in adults over 55, and the risk increases with age. Females are more likely to develop the condition. Smoking can also greatly increase the chances of developing the disorder. The condition is usually diagnosed by an eye doctor (ophthalmologist) who uses both a routine eye exam and special eye tests, such as optical coherence tomography (OCT), to look at images of the retina. There is no cure for dry macular degeneration, but good nutrition and protection from UV rays can prevent symptoms. If you or a loved one has been diagnosed with dry macular degeneration, talk to a doctor about all treatment options. Support groups can provide additional information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Dry Age-related macular degeneration" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Dry Age-related macular degeneration" returned 25 free, full-text research articles on human participants. First 3 results:

A Role for βA3/A1-Crystallin in Type 2 EMT of RPE Cells Occurring in Dry Age-Related Macular Degeneration.
 

Author(s): Sayan Ghosh, Peng Shang, Hiroto Terasaki, Nadezda Stepicheva, Stacey Hose, Meysam Yazdankhah, Joseph Weiss, Taiji Sakamoto, Imran A Bhutto, Shuli Xia, J Samuel Zigler, Ram Kannan, Jiang Qian, James T Handa, Debasish Sinha

Journal: Invest. Ophthalmol. Vis. Sci.. 2018 03;59(4):AMD104-AMD113.

 

The RPE cells have a major role in the development of dry age-related macular degeneration (AMD). We present novel evidence that βA3/A1-crystallin, encoded by the Cryba1 gene, a protein known to be important for lysosomal clearance in the RPE, also has a role in epithelial-to-mesenchymal ...

Last Updated: 31 Dec 1969

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Comparison of macular pigment optical density in patients with dry and wet age-related macular degeneration.
 

Author(s): Ayhan Ozyurt, Nilufer Kocak, Pınar Akan, Ozlem Gursoy Calan, Taylan Ozturk, Mahmut Kaya, Eyup Karahan, Suleyman Kaynak

Journal: Indian J Ophthalmol. 2017 Jun;65(6):477-481.

 

The aim of the study was to evaluate the macular pigment optical density (MPOD) levels in patients with wet age-related macular degeneration (AMD), dry AMD, and also in healthy controls.

Last Updated: 31 Dec 1969

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Dry age-related macular degeneration like pathology in aged 5XFAD mice: Ultrastructure and microarray analysis.
 

Author(s): Sung Wook Park, Sora Im, Hyoung Oh Jun, Kihwang Lee, Young-Jun Park, Jin Hyoung Kim, Woo Jin Park, Young-Hoon Lee, Jeong Hun Kim

Journal: Oncotarget. 2017 Jun;8(25):40006-40018.

 

Age-related macular degeneration (AMD) is a leading cause of blindness in the elderly. The two types of AMD are: dry and wet AMD. While laser-induced choroidal neovascularization has been used extensively in the studies of wet AMD, there is no established mouse model that fully recapitulates ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Dry Age-related macular degeneration" returned 8 free, full-text review articles on human participants. First 3 results:

Optical Coherence Tomography Angiography of Dry Age-Related Macular Degeneration.
 

Author(s): Nadia K Waheed, Eric M Moult, James G Fujimoto, Philip J Rosenfeld

Journal: Dev Ophthalmol. 2016 ;56():91-100.

 

Optical coherence tomography angiography (OCTA) can be used to visualize alterations in the choriocapillaris of patients with dry age-related macular degeneration (AMD). These changes seem to be present during all stages of the disease. Earlier stages are associated with patchy thinning ...

Last Updated: 31 Dec 1969

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Update on Clinical Trials in Dry Age-related Macular Degeneration.
 

Author(s): Ibrahim Taskintuna, M E A Abdalla Elsayed, Patrik Schatz

Journal: Middle East Afr J Ophthalmol. ;23(1):13-26.

 

This review article summarizes the most recent clinical trials for dry age-related macular degeneration (AMD), the most common cause of vision loss in the elderly in developed countries. A literature search through websites https://www.pubmed.org and https://www.clinicaltrials.gov/, ...

Last Updated: 31 Dec 1969

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The Dry Form of Age-Related Macular Degeneration (AMD): The Current Concepts of Pathogenesis and Prospects for Treatment.
 

Author(s): Hanna M Zając-Pytrus, Agnieszka Pilecka, Anna Turno-Kręcicka, Joanna Adamiec-Mroczek, Marta Misiuk-Hojło

Journal: Adv Clin Exp Med. ;24(6):1099-104.

 

Age-related macular degeneration (AMD) is a disease that causes varying degrees of blindness, which afflicts millions of adults in their later years. Preliminary changes occur during normal aging, but in some individuals the pathology leads to the development of AMD. The pathology ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 30 Jan 2018

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PRIMA US-Feasibility Study in Atrophic Dry AMD
 

Status: Recruiting

Condition Summary: Dry Age-related Macular Degeneration

 

Last Updated: 27 Apr 2018

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Subretinal Transplantation of Retinal Pigment Epitheliums in Treatment of Age-related Macular Degeneration Diseases
 

Status: Recruiting

Condition Summary: Dry Age-related Macular Degeneration

 

Last Updated: 31 Jan 2018

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