Eclampsia

Common Name(s)

Eclampsia

Eclampsia is a very serious condition in pregnant women. Eclampsia follows a condition called preeclampsia, which is caused by high blood pressure and large amounts of protein in the urine. If not treated, preeclampsia may turn into eclampsia, in which symptoms include intense headaches, confusion, vision changes, seizures and unconsciousness that may lead to a coma. Eclampsia is dangerous for both the mother and the baby, but in the majority of cases, preeclampsia is diagnosed and treated by a physician before it develops into eclampsia. Primary treatment for eclampsia involves recognition of preeclampsia and anti-seizure medication to prevent the woman from moving into eclampsia. If this is not done, treatment of eclampsia includes immediately delivering the baby and medication to control high blood pressure and stop seizures. Eclampsia is dangerous, but recognizing symptoms of preeclampsia early is the best way to prevent it.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Eclampsia" for support, advocacy or research.

H.E.L.L.P. Syndrome International Foundation, S.a, UK, USA

HELLP Syndrome is a life-threatening condition to both mother and unborn baby during gestation. Our goal: To enhance and extend life.

Last Updated: 19 Aug 2013

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Preeclampsia Foundation

The Preeclampsia Foundation is a 501(c)(3) non-profit organization whose mission is to reduce maternal and infant illness and death due to preeclampsia and other hypertensive disorders of pregnancy by providing patient support and education, raising public awareness, catalyzing research and improving health care practices. We envision a world where preeclampsia no longer threatens the lives of mothers and babies.

Last Updated: 23 Oct 2014

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Eclampsia" for support, advocacy or research.

H.E.L.L.P. Syndrome International Foundation, S.a, UK, USA

HELLP Syndrome is a life-threatening condition to both mother and unborn baby during gestation. Our goal: To enhance and extend life.

Last Updated: 19 Aug 2013

View Details
Preeclampsia Foundation

The Preeclampsia Foundation is a 501(c)(3) non-profit organization whose mission is to reduce maternal and infant illness and death due to preeclampsia and other hypertensive disorders of pregnancy by providing patient support and education, raising public awareness, catalyzing research and improving health care practices. We envision a world where preeclampsia no longer threatens the lives of mothers and babies.

http://www.preeclampsia.org

Last Updated: 23 Oct 2014

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General Resources

The Preeclampsia Registry

The Preeclampsia Registry is a "Living Database" bringing together those affected, their family members, and researchers to advance knowledge and discover preventions and treatments for preeclampsia, HELLP syndrome, and related hypertensive disorders

Updated 23 Oct 2014

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Eclampsia" returned 1010 free, full-text research articles on human participants. First 3 results:

The expression and function of KCNQ potassium channels in human chorionic plate arteries from women with normal pregnancies and pre-eclampsia.
 

Author(s): Xiaohong Wei, Yujiao Zhang, Benlan Yin, Jing Wen, Jun Cheng, Xiaodong Fu

Journal:

 

Pre-eclampsia is associated with altered maternal and placental vascular reactivity. Kv7 channels (encoded by KCNQ 1-5 genes) are a potential contributor to the regulation of vascular tone in CPAs (chorionic plate arteries) during normal pregnancy. The aim of this study is to establish ...

Last Updated: 31 Dec 1969

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Changes in the Expression of AQP4 and AQP9 in the Hippocampus Following Eclampsia-Like Seizure.
 

Author(s): Xinjia Han, Qian Huang, Lei Liu, Xiaoyan Sha, Bihui Hu, Huishu Liu

Journal:

 

Eclampsia is a hypertensive disorder of pregnancy that is defined by the new onset of grand mal seizures on the basis of pre-eclampsia. Until now, the mechanisms underlying eclampsia were poorly understood. Brain edema is considered a leading cause of eclamptic seizures; aquaporins ...

Last Updated: 31 Dec 1969

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Determinants of magnesium sulphate use in women hospitalized at <29 weeks with severe or non-severe pre-eclampsia.
 

Author(s): Dane A De Silva, Lily Proctor, Peter von Dadelszen, Meghan McCoach, Tang Lee, , Laura A Magee

Journal:

 

Magnesium sulphate is recommended by international guidelines to prevent eclampsia among women with pre-eclampsia, especially when it is severe, but fewer than 70% of such women receive magnesium sulphate. We aimed to identify variables that prompt Canadian physicians to administer ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Eclampsia" returned 125 free, full-text review articles on human participants. First 3 results:

[Haemorrhagic stroke of the brainstem secondary to postpartum eclampsia: about a case and literature review].
 

Author(s): Khadija Ennaqui, Assia Makayssi, Houssine Boufettal, Naima Samouh

Journal:

 

Strokes are rare but severe accidents during pregnancy and post-partum period. They are responsible for high mortality and morbidity rates. Pre-eclampsia, eclampsia, and strokes are significantly related. Endothelial dysfunction, alteration of brain self-regulation and severe hypertension ...

Last Updated: 31 Dec 1969

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Placental growth factor and pre-eclampsia.
 

Author(s): K Chau, A Hennessy, A Makris

Journal: J Hum Hypertens. 2017 Dec;31(12):782-786.

 

Placental growth factor (PlGF) is an increasingly important molecule in the prediction, diagnosis and treatment of pre-eclampsia. It has pro-angiogenic effects on the feto-placental circulation and supports trophoblast growth. Mechanisms by which PlGF expression is regulated continue ...

Last Updated: 31 Dec 1969

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Spot protein-creatinine ratio and spot albumin-creatinine ratio in the assessment of pre-eclampsia: a diagnostic accuracy study with decision-analytic model-based economic evaluation and acceptability analysis.
 

Author(s): Jason Waugh, Richard Hooper, Edmund Lamb, Stephen Robson, Andrew Shennan, Fiona Milne, Christopher Price, Shakila Thangaratinam, Vladislav Berdunov, Jenn Bingham

Journal: Health Technol Assess. 2017 Oct;21(61):1-90.

 

The National Institute for Health and Care Excellence (NICE) guidelines highlighted the need for 'large, high-quality prospective studies comparing the various methods of measuring proteinuria in women with new-onset hypertensive disorders during pregnancy'.

Last Updated: 31 Dec 1969

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Use of Sildenafil Citrate in Management of Mild Pre-eclampsia
 

Status: Recruiting

Condition Summary: Pre-Eclampsia; Mild

 

Last Updated: 24 Aug 2017

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Saccadic Reaction Time and Preterm Pre-eclampsia
 

Status: Recruiting

Condition Summary: Pre-eclampsia

 

Last Updated: 3 Apr 2017

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Podocyturia as Predictive Factor for Pre-eclampsia
 

Status: Not yet recruiting

Condition Summary: Pre-Eclampsia

 

Last Updated: 17 Oct 2017

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