Ectodermal Dysplasia

Common Name(s)

Ectodermal Dysplasia, Ectodermal Dysplasias

Ectodermal dysplasias (ED) are a group of about 150 heritable disorders that affect the ectoderm, a layer of tissue that contributes to the formation of many parts of the body, including the skin, sweat glands, hair, teeth, and nails. Symptoms can range from mild to severe and may include dental abnormalities; brittle, sparse or absent hair; abnormal fingernails; inability to perspire (hypohidrosis); various skin problems; and other symptoms. Different types of ectodermal dysplasias are caused by mutations in different genes, and can be inherited in a variety of ways. There are no cures for ED, but many treatments are available to address the individual symptoms.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ectodermal Dysplasia" for support, advocacy or research.

National Foundation for Ectodermal Dysplasias

The National Foundation for Ectodermal Dysplasias’ mission is to empower and connect people touched by ectodermal dysplasias through education, support, and research.

Last Updated: 12 Feb 2018

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ectodermal Dysplasia" for support, advocacy or research.

National Foundation for Ectodermal Dysplasias

The National Foundation for Ectodermal Dysplasias’ mission is to empower and connect people touched by ectodermal dysplasias through education, support, and research.

http://www.nfed.org

Last Updated: 12 Feb 2018

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Ectodermal Dysplasia" returned 228 free, full-text research articles on human participants. First 3 results:

Rehabilitation of ectodermal dysplasia patients presenting with hypodontia: outcomes of implant rehabilitation part 1.
 

Author(s): Mariela Machado, Christine Wallace, Bruce Austin, Suhas Deshpande, Agnes Lai, Terry Whittle, Iven Klineberg

Journal: J Prosthodont Res. 2018 Oct;62(4):473-478.

 

This study has evaluated the pre and post perceptions of patients with ectodermal dysplasia (ED) who have been referred to Westmead Centre for Oral Health for treatment with dental implants.

Last Updated: 31 Dec 1969

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Prenatal Correction of X-Linked Hypohidrotic Ectodermal Dysplasia.
 

Author(s): Holm Schneider, Florian Faschingbauer, Sonia Schuepbach-Mallepell, Iris Körber, Sigrun Wohlfart, Angela Dick, Mandy Wahlbuhl, Christine Kowalczyk-Quintas, Michele Vigolo, Neil Kirby, Corinna Tannert, Oliver Rompel, Wolfgang Rascher, Matthias W Beckmann, Pascal Schneider

Journal: N. Engl. J. Med.. 2018 04;378(17):1604-1610.

 

Genetic deficiency of ectodysplasin A (EDA) causes X-linked hypohidrotic ectodermal dysplasia (XLHED), in which the development of sweat glands is irreversibly impaired, an condition that can lead to life-threatening hyperthermia. We observed normal development of mouse fetuses with ...

Last Updated: 31 Dec 1969

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SIBLINGS AFFECTED BY ECTRODACTYLY-ECTODERMAL DYSPLASIA AND CLEFT LIP/PALATE (EEC) SYNDROME PRESENTING NORMAL PARENTS: GERMLINE MOSAICISM?
 

Author(s): Rafael Fabiano Machado Rosa, Samir Abou Ghaouche de Moraes, Leonardo Paludo Sulczinski, Filipe Augusto da Silva, Olga Gaio Milner, Silvana Rodrigues Streit Pires, Osvaldo Alfonso Pinto Artigalas, Rosana Cardoso Manique Rosa, Paulo Ricardo Gazzola Zen

Journal: Rev Paul Pediatr. ;35(2):234-238.

 

EEC is an acronym for an autosomal dominant syndrome clinically characterized by ectrodactyly (E), ectodermal dysplasia (E) and cleft lip/palate (C). Our aim was to describe a rare case of siblings affected by ectrodactyly, ectodermal dysplasia and cleft lip/palate (EEC) syndrome ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Ectodermal Dysplasia" returned 10 free, full-text review articles on human participants. First 3 results:

Ectodermal dysplasia-skin fragility syndrome with a new mutation.
 

Author(s): Emine Tugba Alatas, Asude Kara, Murat Kara, Gursoy Dogan, Onur Baysal

Journal: Indian J Dermatol Venereol Leprol. ;83(4):476-479.

 

Last Updated: 31 Dec 1969

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EDA mutation as a cause of hypohidrotic ectodermal dysplasia: a case report and review of the literature.
 

Author(s): S X Huang, J L Liang, W G Sui, H Lin, W Xue, J J Chen, Y Zhang, W W Gong, Y Dai, M L Ou

Journal:

 

Ectodermal dysplasia (ED) represents a collection of rare disorders that result from a failure of development of the tissues derived from the embryonic ectoderm. ED is often associated with hair, teeth, and skin abnormalities, which are serious conditions affecting the quality of ...

Last Updated: 31 Dec 1969

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Molecular basis of hypohidrotic ectodermal dysplasia: an update.
 

Author(s): Wieslaw H Trzeciak, Ryszard Koczorowski

Journal: J. Appl. Genet.. 2016 Feb;57(1):51-61.

 

Recent advances in understanding the molecular events underlying hypohidrotic ectodermal dysplasia (HED) caused by mutations of the genes encoding proteins of the tumor necrosis factor α (TNFα)-related signaling pathway have been presented. These proteins are involved in signal ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 5 Nov 2018

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Genetic and Functional Analysis of Aplasia Cutis Congenital (ACC)
 

Status: Recruiting

Condition Summary: Aplasia Cutis Congenita

 

Last Updated: 5 Nov 2018

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Comparison Between Acrylic and Soft Liner Telescopic Overdentures Regarding Patient Satisfaction
 

Status: Not yet recruiting

Condition Summary: Patient Satisfaction; Retention; Periodontal Health

 

Last Updated: 23 Apr 2017

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