Endometrial cancer

Common Name(s)

Endometrial cancer

Endometrial cancer is a type of cancer that begins in cells of the endometrium or lining of the uterus in women. Endometrial cancer is the 6th most common cancer in women worldwide, but is more common in high income countries. Risk increases with age, with most diagnosed after menopause.

Symptoms of endometrial cancer include abnormal vaginal bleeding or discharge, pelvic pain, and weight-loss. In general, symptoms occur in early stages of the cancer so it is usually diagnosed early. The overall 5 year survival rate is relatively high and is increasing due to medical research.

Most risk factors for endometrial cancer affect a woman’s estrogen (hormone) level. These include estrogen-only hormone replacement therapy and certain hormone therapies for breast cancer (tamoxifen). Conditions affecting ovulation (polycystic ovarian syndrome, diabetes and obesity) may increase a woman’s risk. Other risk factors include beginning your period before age 12, late menopause, never having been pregnant, and a personal history of breast or ovarian cancer. Lynch syndrome, a genetic condition, also increases a woman’s risk.

Diagnosis may include a pelvic exam, a transvaginal ultrasound (uses sound waves to picture the uterus), an exam using a hysteroscope (thin tube to see inside the uterus), and a uterine biopsy (testing a small piece of tissue). To confirm the diagnosis and stage of cancer, a D&C (special procedure in which cells are scraped from the uterine wall) may be performed.

Treatments may include surgery, hormonal therapy, chemotherapy, and radiation therapy. Prevention includes birth control pills containing both progesterone and estrogen, exercise, maintaining a healthy weight and stopping smoking. If you have been diagnosed with endometrial cancer, talk to your doctor about the most current treatment options. Support groups are good sources of information and can connect you living with endometrial cancer.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Endometrial cancer" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

Last Updated: 12 Dec 2012

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Endometrial cancer" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

http://www.4thangel.org

Last Updated: 12 Dec 2012

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Endometrial cancer" returned 1679 free, full-text research articles on human participants. First 3 results:

Association of Foxp3 promoter polymorphisms with susceptibility to endometrial cancer in the Chinese Han women.
 

Author(s): Di You, Yanyun Wang, Yan Zhang, Qin Li, Xiuzhang Yu, Mingwei Yuan, Zhu Lan, Xi Zeng, Bin Zhou, Yaping Song, Min Su, Lin Zhang, Mingrong Xi

Journal: Medicine (Baltimore). 2018 May;97(18):e0582.

 

To evaluate the association between Foxp3 gene polymorphisms (rs3761548 and rs5902434) and susceptibility to endometrial cancer (EC), we report a hospital case-control study involving 602 women, consisting of 269 patients with EC and 333 healthy controls. Genotyping was performed ...

Last Updated: 31 Dec 1969

Go To URL
Clinical impact of endometrial cancer stratified by genetic mutational profiles, POLE mutation, and microsatellite instability.
 

Author(s): Tomoko Haruma, Takeshi Nagasaka, Keiichiro Nakamura, Junko Haraga, Akihiro Nyuya, Takeshi Nishida, Ajay Goel, Hisashi Masuyama, Yuji Hiramatsu

Journal:

 

The molecular characterization of endometrial cancer (EC) can facilitate identification of various tumor subtypes. Although EC patients with POLE mutations reproducibly demonstrate better prognosis, the outcome of patients with microsatellite instability (MSI) remains controversial. ...

Last Updated: 31 Dec 1969

Go To URL
Survival benefits of pelvic lymphadenectomy versus pelvic and para-aortic lymphadenectomy in patients with endometrial cancer: A meta-analysis.
 

Author(s): Weina Guo, Jing Cai, Min Li, Hongbo Wang, Yi Shen

Journal: Medicine (Baltimore). 2018 Jan;97(1):e9520.

 

Despite that pelvic and para-aortic lymphadenectomy (PPaLND) is recommended as part of accurate surgical staging by International Federation of Gynecology and Obstetrics (FIGO) in endometrial cancer, the impact of para-aortic lymphadenectomy on survival remains controversial. The ...

Last Updated: 31 Dec 1969

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Endometrial cancer" returned 186 free, full-text review articles on human participants. First 3 results:

Primary ovarian small cell carcinoma of pulmonary type with coexisting endometrial carcinoma in a breast cancer patient receiving tamoxifen: A case report and literature review.
 

Author(s): Lei Yin, Jianning Li, Yunhai Wei, Dejian Ma, Yamei Sun, Yanlai Sun

Journal: Medicine (Baltimore). 2018 Jun;97(23):e10900.

 

Small cell carcinoma of the ovary (SCCO) is a rare and aggressive extra-pulmonary variant of small cell tumors of uncertain histogenesis. The pathogenesis and optimal treatment of SCCO is unclear. We present a very rare case of a synchronous primary ovarian small cell carcinoma and ...

Last Updated: 31 Dec 1969

Go To URL
Hormone therapy as a management strategy for lung metastasis after 5 years of endometrial cancer: A case report and literature review.
 

Author(s): Huifang Zhao, Yushuang Yao, Hongjuan Yang, Dehua Ma, Aiping Chen

Journal: Medicine (Baltimore). 2017 Dec;96(51):e9223.

 

Endometrial cancer patients with lung metastases are rare, and more rarely with long-term management of progesterone after recurrence.

Last Updated: 31 Dec 1969

Go To URL
Diagnostic hysteroscopy and the risk of malignant cells intraabdominal spread in women with endometrial cancer.
 

Author(s): Norbert Stachowicz, Diana Mazurek, Tomasz Łoziński, Artur Czekierdowski

Journal: Ginekol. Pol.. 2017 ;88(10):562-567.

 

Although hysteroscopy is currently the undisputed gold standard for the examination of the uterine cavity in women with suspected endometrial cancer, it remains controversial as a procedure that can enhance metastasis spread. Endometrial cancer cells may shed during hysteroscopy and ...

Last Updated: 31 Dec 1969

Go To URL
 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of Avelumab in Patients With MSS, MSI-H and POLE-mutated Recurrent or Persistent Endometrial Cancer
 

Status: Recruiting

Condition Summary: Metastatic Endometrial Cancer

 

Last Updated: 17 May 2018

Go to URL
Carboplatin, Paclitaxel With or Without Avelumab in Advanced or Recurrent Endometrial Cancer
 

Status: Not yet recruiting

Condition Summary: Endometrial Cancer

 

Last Updated: 13 Apr 2018

Go to URL

Last Updated: 11 Jul 2018

Go to URL