Endometrial cancer

Common Name(s)

Endometrial cancer

Endometrial cancer is a type of cancer that begins in cells of the endometrium or lining of the uterus in women. Endometrial cancer is the 6th most common cancer in women worldwide, but is more common in high income countries. Risk increases with age, with most diagnosed after menopause.

Symptoms of endometrial cancer include abnormal vaginal bleeding or discharge, pelvic pain, and weight-loss. In general, symptoms occur in early stages of the cancer so it is usually diagnosed early. The overall 5 year survival rate is relatively high and is increasing due to medical research.

Most risk factors for endometrial cancer affect a woman’s estrogen (hormone) level. These include estrogen-only hormone replacement therapy and certain hormone therapies for breast cancer (tamoxifen). Conditions affecting ovulation (polycystic ovarian syndrome, diabetes and obesity) may increase a woman’s risk. Other risk factors include beginning your period before age 12, late menopause, never having been pregnant, and a personal history of breast or ovarian cancer. Lynch syndrome, a genetic condition, also increases a woman’s risk.

Diagnosis may include a pelvic exam, a transvaginal ultrasound (uses sound waves to picture the uterus), an exam using a hysteroscope (thin tube to see inside the uterus), and a uterine biopsy (testing a small piece of tissue). To confirm the diagnosis and stage of cancer, a D&C (special procedure in which cells are scraped from the uterine wall) may be performed.

Treatments may include surgery, hormonal therapy, chemotherapy, and radiation therapy. Prevention includes birth control pills containing both progesterone and estrogen, exercise, maintaining a healthy weight and stopping smoking. If you have been diagnosed with endometrial cancer, talk to your doctor about the most current treatment options. Support groups are good sources of information and can connect you living with endometrial cancer.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Endometrial cancer" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

Last Updated: 12 Dec 2012

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General Support Organizations

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How do you compare to others with this condition?

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Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Endometrial cancer" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

http://www.4thangel.org

Last Updated: 12 Dec 2012

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Endometrial cancer" returned 1698 free, full-text research articles on human participants. First 3 results:

Liposomal Curcumin Targeting Endometrial Cancer Through the NF-κB Pathway.
 

Author(s): Hanzi Xu, Zhen Gong, Siying Zhou, Sujin Yang, Dandan Wang, Xiu Chen, Jiaqi Wu, Liucheng Liu, Shanliang Zhong, Jianhua Zhao, Jinhai Tang

Journal: Cell. Physiol. Biochem.. 2018 ;48(2):569-582.

 

Emerging evidence suggests that curcumin possesses chemopreventive properties against various cancers. However, its poor bioavailability limits its clinical application. In this study, we aimed to utilize encapsulation in liposomes (Lipo) as a strategy for the clinical administration ...

Last Updated: 31 Dec 1969

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Association of Foxp3 promoter polymorphisms with susceptibility to endometrial cancer in the Chinese Han women.
 

Author(s): Di You, Yanyun Wang, Yan Zhang, Qin Li, Xiuzhang Yu, Mingwei Yuan, Zhu Lan, Xi Zeng, Bin Zhou, Yaping Song, Min Su, Lin Zhang, Mingrong Xi

Journal: Medicine (Baltimore). 2018 May;97(18):e0582.

 

To evaluate the association between Foxp3 gene polymorphisms (rs3761548 and rs5902434) and susceptibility to endometrial cancer (EC), we report a hospital case-control study involving 602 women, consisting of 269 patients with EC and 333 healthy controls. Genotyping was performed ...

Last Updated: 31 Dec 1969

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One-Step Nucleic Acid Amplification (OSNA): A fast molecular test based on CK19 mRNA concentration for assessment of lymph-nodes metastases in early stage endometrial cancer.
 

Author(s): Francesco Fanfani, Giorgia Monterossi, Viola Ghizzoni, Esther D Rossi, Giorgia Dinoi, Frediano Inzani, Anna Fagotti, Salvatore Gueli Alletti, Francesca Scarpellini, Camilla Nero, Angela Santoro, Giovanni Scambia, Gian F Zannoni

Journal:

 

The aim of the current study is to evaluate the detection rate of micro- and macro-metastases of the One-Step Nucleic Acid Amplification (OSNA) compared to frozen section examination and subsequent ultra-staging examination in early stage endometrial cancer (EC).

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Endometrial cancer" returned 188 free, full-text review articles on human participants. First 3 results:

Clinical significance of matrix metalloproteinase-2 in endometrial cancer: A systematic review and meta-analysis.
 

Author(s): Chang Liu, Ying Li, Shasha Hu, Yao Chen, Li Gao, Dajiang Liu, Hongtao Guo, Yongxiu Yang

Journal: Medicine (Baltimore). 2018 Jul;97(29):e10994.

 

Matrix metalloproteinase-2 (MMP-2), a member of the zinc-dependent metalloproteinase gene family, plays a vital role in cancer invasion, metastasis, and progression. This systematic review and meta-analysis aims to explore the clinical significance of MMP-2 expression in endometrial cancer.

Last Updated: 31 Dec 1969

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Primary ovarian small cell carcinoma of pulmonary type with coexisting endometrial carcinoma in a breast cancer patient receiving tamoxifen: A case report and literature review.
 

Author(s): Lei Yin, Jianning Li, Yunhai Wei, Dejian Ma, Yamei Sun, Yanlai Sun

Journal: Medicine (Baltimore). 2018 Jun;97(23):e10900.

 

Small cell carcinoma of the ovary (SCCO) is a rare and aggressive extra-pulmonary variant of small cell tumors of uncertain histogenesis. The pathogenesis and optimal treatment of SCCO is unclear. We present a very rare case of a synchronous primary ovarian small cell carcinoma and ...

Last Updated: 31 Dec 1969

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Prediction models for endometrial cancer for the general population or symptomatic women: A systematic review.
 

Author(s): Maaike Alblas, Kimberley B Velt, Nora Pashayan, Martin Widschwendter, Ewout W Steyerberg, Yvonne Vergouwe

Journal: Crit. Rev. Oncol. Hematol.. 2018 Jun;126():92-99.

 

To provide an overview of prediction models for the risk of developing endometrial cancer in women of the general population or for the presence of endometrial cancer in symptomatic women.

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Atezolizumab Trial in Endometrial Cancer - AtTEnd
 

Status: Not yet recruiting

Condition Summary: Endometrial Cancer

 

Last Updated: 5 Sep 2018

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Study of Avelumab in Patients With MSS, MSI-H and POLE-mutated Recurrent or Persistent Endometrial Cancer
 

Status: Recruiting

Condition Summary: Metastatic Endometrial Cancer

 

Last Updated: 17 May 2018

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Carboplatin, Paclitaxel With or Without Avelumab in Advanced or Recurrent Endometrial Cancer
 

Status: Not yet recruiting

Condition Summary: Endometrial Cancer

 

Last Updated: 13 Apr 2018

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