Enteropathy-associated T-cell lymphoma

Common Name(s)

Enteropathy-associated T-cell lymphoma

Enteropathy-associated T-cell lymphoma (EATL) is a very rare form of intestinal cancer that affects T-cells. T-cells are a type of white blood cell that function as part of the body’s adaptive immune system. This type of cancer is most commonly seen in individuals with chronic or untreated celiac disease. Celiac disease is an autoimmune disorder of the small intestine in which the body is unable to process gluten.

Symptoms of EATL include diarrhea, nausea, fatigue, abdominal pain, and rapid weight loss. This type of cancer is more common in those of European descent. If celiac disease is diagnosed with EATL, then the initial treatment will usually involve adaptation of a gluten-free diet. Additional treatment for the cancer will vary widely between individuals, but may involve a combination of chemotherapy, radiation, and other mediations. Talk to your doctor about the most current treatment options and to find available support groups.

Source: Advocacy organizations associated with the condition.

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Enteropathy-associated T-cell lymphoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Enteropathy-associated T-cell lymphoma" returned 50 free, full-text research articles on human participants. First 3 results:

Enteropathy-associated T cell lymphoma subtypes are characterized by loss of function of SETD2.
 

Author(s): Andrea B Moffitt, Sarah L Ondrejka, Matthew McKinney, Rachel E Rempel, John R Goodlad, Chun Huat Teh, Sirpa Leppa, Susanna Mannisto, Panu E Kovanen, Eric Tse, Rex K H Au-Yeung, Yok-Lam Kwong, Gopesh Srivastava, Javeed Iqbal, Jiayu Yu, Kikkeri Naresh, Diego Villa, Randy D Gascoyne, Jonathan Said, Magdalena B Czader, Amy Chadburn, Kristy L Richards, Deepthi Rajagopalan, Nicholas S Davis, Eileen C Smith, Brooke C Palus, Tiffany J Tzeng, Jane A Healy, Patricia L Lugar, Jyotishka Datta, Cassandra Love, Shawn Levy, David B Dunson, Yuan Zhuang, Eric D Hsi, Sandeep S Dave

Journal: J. Exp. Med.. 2017 05;214(5):1371-1386.

 

Enteropathy-associated T cell lymphoma (EATL) is a lethal, and the most common, neoplastic complication of celiac disease. Here, we defined the genetic landscape of EATL through whole-exome sequencing of 69 EATL tumors. was the most frequently silenced gene in EATL (32% of cases). ...

Last Updated: 31 Dec 1969

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Type II enteropathy-associated T-cell lymphoma features a unique genomic profile with highly recurrent SETD2 alterations.
 

Author(s): Annalisa Roberti, Maria Pamela Dobay, Bettina Bisig, David Vallois, Cloé Boéchat, Evripidis Lanitis, Brigitte Bouchindhomme, Marie-Cécile Parrens, Céline Bossard, Leticia Quintanilla-Martinez, Edoardo Missiaglia, Philippe Gaulard, Laurence de Leval

Journal:

 

Enteropathy-associated T-cell lymphoma (EATL), a rare and aggressive intestinal malignancy of intraepithelial T lymphocytes, comprises two disease variants (EATL-I and EATL-II) differing in clinical characteristics and pathological features. Here we report findings derived from whole-exome ...

Last Updated: 31 Dec 1969

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Enteropathy-associated T-cell lymphoma: An extremely rare cause of chronic diarrhoea.
 

Author(s): C C Liong, S Ravindran, G Gnana Kumar, E F Chin, P S Koh, W K Chan

Journal: Med. J. Malaysia. 2016 04;71(2):88-90.

 

Chronic diarrhoea in tropical countries may be due to a myriad of causes from infective to non-infective. This case report illustrates the challenges faced in the investigation of a middle-age Chinese gentleman who presented with chronic diarrhoea and weight loss. The diagnosis of ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Enteropathy-associated T-cell lymphoma" returned 2 free, full-text review articles on human participants. First 3 results:

[Molecular pathogenesis of peripheral T cell lymphoma (2): extranodal NK/T cell lymphoma, nasal type, adult T cell leukemia/lymphoma and enteropathy associated T cell lymphoma].
 

Author(s): Lucile Couronné, Christian Bastard, Philippe Gaulard, Olivier Hermine, Olivier Bernard

Journal: Med Sci (Paris). 2015 Nov;31(11):1023-33.

 

Peripheral T-cell lymphomas (PTCL) belong to the group of non-Hodgkin lymphoma and particularly that of mature T /NK cells lymphoproliferative neoplasms. The 2008 WHO classification describes different PTCL entities with varying prevalence. With the exception of histologic subtype ...

Last Updated: 31 Dec 1969

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Enteropathy-associated T-cell lymphoma: a review on clinical presentation, diagnosis, therapeutic strategies and perspectives.
 

Author(s): M-O Chandesris, G Malamut, V Verkarre, B Meresse, E Macintyre, R Delarue, M-T Rubio, F Suarez, B Deau-Fischer, N Cerf-Bensussan, N Brousse, C Cellier, O Hermine

Journal: Gastroenterol. Clin. Biol.. 2010 Nov;34(11):590-605.

 

Enteropathy-associated T-cell lymphoma (EATL) is a rare complication of celiac disease (<1% of lymphomas) and has a poor prognosis.

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

CHP-BV Followed by Consolidation With High-dose Therapy / ASCT as Frontline Treatment of Patients With EATL Type 1.
 

Status: Recruiting

Condition Summary: Enteropathy Associated T-cell Lymphoma

 

Last Updated: 13 Mar 2018

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T Cells Expressing a Fully-Human Anti-CD30 Chimeric Antigen Receptor for Treating CD30-Expressing Lymphomas
 

Status: Recruiting

Condition Summary: Lymphoma, Large-Cell, Anaplasitc; Hodgkin Disease; Lymphoma, Hodgkins; Enteropathy-Associated T-Cell Lymphoma; Lymphoma, Extranodal NK-T-Cell

 

Last Updated: 22 Aug 2018

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Nivolumab in Treating Patients With Relapsed or Refractory Peripheral T-cell Lymphoma
 

Status: Recruiting

Condition Summary: Blastic Plasmacytoid Dendritic Cell Neoplasm; Hepatosplenic T-Cell Lymphoma; HTLV-1 Infection; NK-Cell Lymphoma, Unclassifiable; Primary Systemic Anaplastic Large Cell Lymphoma, ALK-Negative; Recurrent Adult T-Cell Leukemia/Lymphoma; Recurrent Anaplastic Large Cell Lymphoma; Recurrent Angioimmunoblastic T-cell Lymphoma; Recurrent Enteropathy-Associated T-Cell Lymphoma; Recurrent Mycosis Fungoides; Refractory Adult T-Cell Leukemia/Lymphoma; Refractory Anaplastic Large Cell Lymphoma; Refractory Angioimmunoblastic T-cell Lymphoma; Refractory Enteropathy-Associated T-Cell Lymphoma; Refractory Mycosis Fungoides; Refractory Nasal Type Extranodal NK/T-Cell Lymphoma; Refractory Peripheral T-Cell Lymphoma, Not Otherwise Specified

 

Last Updated: 27 Apr 2018

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