Langerhans cell histiocytosis

Common Name(s)

Langerhans cell histiocytosis, Eosinophilic Granuloma, Hand-Schuller-Christian disease

Langerhans cell histiocytosis (LCH) is a disorder that primarily affects children, but is also found in adults of all ages. People with LCH produce too many Langerhans cells or histiocytes, a form of white blood cell found in healthy people that is supposed to protect the body from infection. In people with LCH, these cells multiply excessively and build up in certain areas of the body, causing tumors called granulomas to form. The symptoms vary among affected individuals, and the cause of LCH is unknown. In most cases, this condition is not life-threatening. Some people do experience life-long problems associated with LCH.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Langerhans cell histiocytosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Langerhans cell histiocytosis" returned 339 free, full-text research articles on human participants. First 3 results:

The application of x-ray, computed tomography, and magnetic resonance imaging on 22 pediatric Langerhans cell histiocytosis patients with long bone involvement: A retrospective analysis.
 

Author(s): Xiaojun Zhang, Jing Zhou, Xuee Chai, Guiling Chen, Bin Guo, Lei Ni, Peng Wu

Journal: Medicine (Baltimore). 2018 Apr;97(17):e0411.

 

The studies focusing on x-ray, computed tomography (CT), and magnetic resonance imaging (MRI) in pediatric Langerhans cell histiocytosis (LCH) patients were still rare. Therefore, we aimed to evaluate the application of x-ray, CT, and MRI in pediatric LCH patients with long bone involvement.Total ...

Last Updated: 31 Dec 1969

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[BRAF-V600E mutation and its clinical significance in children with Langerhans cell histiocytosis].
 

Author(s): Xue Tang, Xia Guo, Lin-Yong Sun, Yuan Ai, Xue Yang, Jing-Jing Sun, Jian-Rong Wu, Ju Gao

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2018 Apr;20(4):290-294.

 

To investigate the clinical significance of BRAF-V600E mutation in children with Langerhans cell histiocytosis (LCH).

Last Updated: 31 Dec 1969

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Pediatric Langerhans cell histiocytosis of the temporal bone: clinical and imaging studies of 27 cases.
 

Author(s): Hui Zheng, Zhengrong Xia, Wenjun Cao, Yun Feng, Shuxian Chen, Yu-Hua Li, Deng-Bin Wang

Journal:

 

We aimed to evaluate the clinical and imaging presentations of Langerhans cell histiocytosis (LCH) in the pediatric temporal bone.

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Langerhans cell histiocytosis" returned 52 free, full-text review articles on human participants. First 3 results:

Successful management of multiple-systemic Langerhans cell histiocytosis involving endocrine organs in an adult: A case report and review of literature.
 

Author(s): Junhui Xie, Zhen Li, Yi Tang

Journal: Medicine (Baltimore). 2018 Jun;97(26):e11215.

 

Langerhans cell histiocytosis (LCH) involving non-endocrine organs has been frequently reported, whereas LCH involving endocrine organs is rare and the mechanism is unclear.

Last Updated: 31 Dec 1969

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Pulmonary Langerhans' cell histiocytosis in adults.
 

Author(s): Elżbieta Radzikowska

Journal: Adv Respir Med. 2017 ;85(5):277-289.

 

Pulmonary Langerhans' cell histiocytosis (PLCH) is a rare disorder of unknown cause characterised by the infiltration of the lungs and other organs by the bone marrow derived Langerhans' cells, which carry mutations of BRAF gene and/or NRAS, KRAS and MAP2K1 genes. It occurs predominantly ...

Last Updated: 31 Dec 1969

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How I manage pulmonary Langerhans cell histiocytosis.
 

Author(s): Gwenaël Lorillon, Abdellatif Tazi

Journal:

 

Pulmonary Langerhans cell histiocytosis (PLCH) is a rare sporadic cystic lung disease of unknown aetiology that is characterised by the infiltration and destruction of the wall of distal bronchioles by CD1a Langerhans-like cells. In adults, PLCH is frequently isolated and affects ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 2 Aug 2018

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Last Updated: 2 May 2018

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Vinblastine/Prednisone Versus Single Therapy With Cytarabine for Langerhans Cell Histiocytosis (LCH)
 

Status: Recruiting

Condition Summary: Langerhans Cell Histiocytosis

 

Last Updated: 15 Nov 2017

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