Epidermal nevus

Common Name(s)

Epidermal nevus

Epidermal nevi are congenital lesions that affect about 1 in 1,000 people. They appear at or shortly after birth as localized epidermal thickening with hyperpigmentation that frequently follow the lines of Blaschko, suggesting that they result from postzygotic somatic mutation in the skin ({10:Paller et al., 1994}). A rare subgroup of epidermal nevi is clinically indistinguishable from other epidermal nevi, but displays histopathologic features typical of epidermolytic hyperkeratosis (see EHK, {113800}), and patients with this type of epidermal nevi sometimes have offspring with generalized EHK ({10:Paller et al., 1994}). Woolly hair nevus is a rare condition characterized by the development of woolly hair in a restricted area on the scalp, either present at birth or becoming evident later in life when scalp hair begins to grow. Woolly hair nevus can be an isolated finding or can occur in association with additional ectodermal defects; epidermal nevi have been reported in association with woolly hair nevi (summary by {11:Ramot and Zlotogorski, 2015}). Nevus sebaceous, a benign congenital skin lesion that preferentially affects the scalp and face, is characterized by hairless, yellow-orange plaques of various size and shape. Histology shows that nevus sebaceous is a hamartoma consisting of epidermal, sebaceous, and apocrine elements. About 24% of nevi develop secondary tumors, some of which may be malignant (summary by {2:Groesser et al., 2012}). Also see giant pigmented hairy nevus ({137550}) and malignant melanoma ({155600}).
 

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Condition Specific Organizations

Following organizations serve the condition "Epidermal nevus" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Epidermal nevus" returned 45 free, full-text research articles on human participants. First 3 results:

A Case of Infundibulocystic Basal Cell Carcinoma Clinically Mimicking a Melanocytic Nevus Associated with Epidermal Cysts.
 

Author(s): Yushi Kawasaki, Shinn-Ichi Ansai, Kazuhisa Fujimoto, Hidehisa Saeki, Seiji Kawana

Journal: J Nippon Med Sch. 2018 ;85(4):228-230.

 

A 52-year-old Japanese woman presented with a 1.5-cm black, glossy, flat, pediculated lump that clinically mimicked a melanocytic nevus on the left temporal side of her head. The subcutaneous tumor beneath the nodule was elastic and hard. A histological examination showed that the ...

Last Updated: 31 Dec 1969

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Is Ki-67, keratin 16, involucrin, and filaggrin immunostaining sufficient to diagnose inflammatory linear verrucous epidermal nevus? A report of eight cases and a comparison with psoriasis vulgaris.
 

Author(s): Jing Peng, Shu-Bin Sun, Pei-Pei Yang, Yi-Ming Fan

Journal: An Bras Dermatol. ;92(5):682-685.

 

Inflammatory linear verrucous epidermal nevus and linear psoriasis are sometimes hard to differentiate clinically and pathologically. Although immunohistochemical expression of keratin 10 (K10), K16, Ki-67, and involucrin may be useful for differentiating both entities, these results ...

Last Updated: 31 Dec 1969

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Successful Treatment of Epidermal Nevus-associated Pruritus with Topical Ketamine-Amitriptyline-Lidocaine.
 

Author(s): Jose A Jaller, Gil Yosipovitch

Journal: Acta Derm. Venereol.. 2018 01;98(1):121-122.

 

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Epidermal nevus" returned 1 free, full-text review articles on human participants. First 3 results:

Oral linear epidermal nevus: a review of the literature and report of two new cases.
 

Author(s): Domenico Tesi, Giuseppe Ficarra

Journal: Head Neck Pathol. 2010 Jun;4(2):139-43.

 

Linear epidermal nevus (LEN) is a sporadic hamartomatous lesion of the skin due to the proliferation of clones of embryonic ectodermal cells, which are arranged according to a typical linear configuration known as Blaschko's lines. Oral involvement of LEN is very rare and few cases ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Open Label Trial Assessing Safety and Efficacy of Burosumab (KRN23), in a Patient With ENS and Hypophosphatemic Rickets
 

Status: Recruiting

Condition Summary: Hypophosphatemia; Hypophosphatemic Rickets; Pain, Chronic

 

Last Updated: 26 Jun 2018

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Identification of Biomarkers for Patients With Vascular Anomalies
 

Status: Recruiting

Condition Summary: Vascular Anomaly; Generalized Lymphatic Anomaly; Kaposiform Hemangioendothelioma; Kaposiform Lymphangiomatosis; Gorham-Stout Disease; Klippel Trenaunay Syndrome; Congenital Lipomatous Overgrowth, Vascular Malformations, and Epidermal Nevi

 

Last Updated: 12 Feb 2018

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