Essential Thrombocythemia

Common Name(s)

Essential Thrombocythemia

Essential thrombocythemia belongs to a group of conditions called myeloproliferative disorders. Myeloproliferative disorders cause platelets, white blood cells and red blood cells to grow abnormally in the bone marrow (the soft tissue inside the hollow part of bones that helps form blood cells). In essential thrombocythemia, the body produces too many platelet cells. The signs and symptoms vary from person to person, with up to two-thirds of patients not having any symptoms when the platelet cell count first increases. Signs and symptoms may include significant increased production of megakaryocyte (a cell in the bone marrow that is responsible for making platelets), enlargement of the spleen (splenomegaly), and bleeding and/or clotting episodes.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Essential Thrombocythemia" for support, advocacy or research.

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MPDSUPPORT.ORG

Since 1994, our MPD-SUPPORT web site and free support email list offers interesting information on chronic myelogenous leukemia, polycythemia vera, essential thrombocythemia, agnogenic myeloid metaplasia, myelodysplasia, and myelofibrosis. Anyone - patient, family member, or health professional, is welcome to join our growing list of subscribers. Our archives are available for you to research information.

Last Updated: 14 Jan 2013

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MPN Research Foundation

The primary mission of the MPN Research Foundation is to stimulate original research in pursuit of new treatments -- and eventually a cure -- for polycythemia vera, essential thrombocythemia and myelofibrosis, known collectively as myeloproliferative neoplasms (MPN).In addition, the MPN Research Foundation promotes collaboration in the scientific community to accelerate research, and serves as a powerful advocacy group for patients and their families

Last Updated: 20 Feb 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Essential Thrombocythemia" for support, advocacy or research.

Logo
MPDSUPPORT.ORG

Since 1994, our MPD-SUPPORT web site and free support email list offers interesting information on chronic myelogenous leukemia, polycythemia vera, essential thrombocythemia, agnogenic myeloid metaplasia, myelodysplasia, and myelofibrosis. Anyone - patient, family member, or health professional, is welcome to join our growing list of subscribers. Our archives are available for you to research information.

http://www.mpdsupport.org

Last Updated: 14 Jan 2013

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MPN Research Foundation

The primary mission of the MPN Research Foundation is to stimulate original research in pursuit of new treatments -- and eventually a cure -- for polycythemia vera, essential thrombocythemia and myelofibrosis, known collectively as myeloproliferative neoplasms (MPN).In addition, the MPN Research Foundation promotes collaboration in the scientific community to accelerate research, and serves as a powerful advocacy group for patients and their families

http://www.mpnresearchfoundation.org

Last Updated: 20 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Essential Thrombocythemia" returned 358 free, full-text research articles on human participants. First 3 results:

Essential thrombocythemia during treatment of acute myeloid leukemia with JAK2 V617F mutation: A case report of a CARE-compliant article.
 

Author(s): Wenwen Ding, Danni Li, Chao Zhuang, Pingping Wei, Wenfeng Mou, Lei Zhang, Hui Liang, Yong Liu

Journal: Medicine (Baltimore). 2018 Jul;97(27):e11331.

 

The JAK2 V617F mutation is frequently found in ET, while it is rare in de novo AML. ET has a low frequency of leukemic transformation. Both secondary AML (sAML) from ET and AML with JAK2 V617F mutation have poor prognoses. Because of the low incidence of JAK2 mutation in acute myeloid ...

Last Updated: 31 Dec 1969

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Ruxolitinib for essential thrombocythemia refractory to or intolerant of hydroxyurea: long-term phase 2 study results.
 

Author(s): Srdan Verstovsek, Francesco Passamonti, Alessandro Rambaldi, Giovanni Barosi, Elisa Rumi, Elisabetta Gattoni, Lisa Pieri, Huiling Zhen, Muriel Granier, Albert Assad, Mario Cazzola, Hagop M Kantarjian, Tiziano Barbui, Alessandro M Vannucchi

Journal: Blood. 2017 10;130(15):1768-1771.

 

Last Updated: 31 Dec 1969

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Application of current prognostic models for primary myelofibrosis in the setting of post-polycythemia vera or post-essential thrombocythemia myelofibrosis.
 

Author(s): A Tefferi, L Saeed, C A Hanson, R P Ketterling, A Pardanani, N Gangat

Journal: Leukemia. 2017 12;31(12):2851-2852.

 

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Essential Thrombocythemia" returned 17 free, full-text review articles on human participants. First 3 results:

Abdominal surgery in patients with essential thrombocythemia: A case report and systematic review of literature.
 

Author(s): Yi Zhu, HongGang Jiang, ZhiHeng Chen, BoHao Lu, JiaMing Wu

Journal: Medicine (Baltimore). 2017 Nov;96(47):e8856.

 

Essential thrombocythemia/thrombocytosis (ET) is characterized by increased bleeding and thrombosis risk during the perioperative period. We report the case of a woman with ET and sigmoid colon cancer, in whom the postoperative course was complicated by anastomotic bleeding. A systematic ...

Last Updated: 31 Dec 1969

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Risk of venous thromboembolism in pregnant women with essential thrombocythemia: a systematic review and meta-analysis.
 

Author(s): Leslie Skeith, Marc Carrier, Susan E Robinson, Samah Alimam, Marc A Rodger

Journal: Blood. 2017 02;129(8):934-939.

 

We performed a meta-analysis to evaluate the risk of venous thromboembolism (VTE) in pregnant women with essential thrombocythemia. Twenty-one trials and 756 pregnancies met inclusion criteria. The absolute VTE risk in the antepartum period is not above a threshold where low-molecular-weight ...

Last Updated: 31 Dec 1969

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The Use of Anagrelide in Myeloproliferative Neoplasms, with Focus on Essential Thrombocythemia.
 

Author(s): Gunnar BirgegÄrd

Journal: Curr Hematol Malig Rep. 2016 10;11(5):348-55.

 

Anagrelide (ANA) is a drug with specific platelet-lowering activity, used primarily in ET, registered as a second-line drug in essential thrombocythemia (ET) in Europe and in some countries as first-line therapy, in USA licensed by FDA for thrombocythemia in myeloproliferative neoplasms ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Anagre Cap. in Patients With High-Risk Essential Thrombocythemia
 

Status: Recruiting

Condition Summary: Essential Thrombocythemia

 

Last Updated: 24 Jul 2017

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Hydroxyurea Versus Aspirin and Hydroxyurea in Essential Thrombocythemia
 

Status: Recruiting

Condition Summary: MPN; Essential Thrombocythemia

 

Last Updated: 24 Jul 2017

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The Ruxo-BEAT Trial in Patients With High-risk Polycythemia Vera or High-risk Essential Thrombocythemia
 

Status: Recruiting

Condition Summary: Polycythemia Vera (PV); Essential Thrombocythemia (ET)

 

Last Updated: 7 Jun 2018

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