Essential hypertension

Common Name(s)

Essential hypertension

The Pickering school held that blood pressure has a continuous distribution, that multiple genes and multiple environmental factors determine the level of one's blood pressure just as the determination of stature and intelligence is multifactorial, and that 'essential hypertension' is merely the upper end of the distribution ({66:Pickering, 1978}). In this view the person with essential hypertension is one who happens to inherit an aggregate of genes determining hypertension (and also is exposed to exogenous factors that favor hypertension). The Platt school took the view that essential hypertension is a simple mendelian dominant trait ({69:Platt, 1963}). {57:McDonough et al. (1964)} defended the monogenic idea. See {58:McKusick (1960)} and {52:Kurtz and Spence (1993)} for reviews. {78:Swales (1985)} reviewed the Platt-Pickering controversy as an 'episode in recent medical history.' The Pickering point of view appears to be more consistent with the observations.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Essential hypertension" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Essential hypertension" returned 1017 free, full-text research articles on human participants. First 3 results:

Association of angiotensin-converting enzyme 2 gene polymorphism and enzymatic activity with essential hypertension in different gender: A case-control study.
 

Author(s): Qi Zhang, Mingyu Cong, Ningning Wang, Xueyan Li, Hao Zhang, Keyong Zhang, Ming Jin, Nan Wu, Changchun Qiu, Jingping Li

Journal: Medicine (Baltimore). 2018 Oct;97(42):e12917.

 

Angiotensin-converting enzyme 2 (ACE2) plays an important role in the development of essential hypertension (EH). The aim of this study was to investigate the relationship of ACE2 gene polymorphisms and enzymatic activity with EH in the northeastern Chinese Han population. 34 single-nucleotide ...

Last Updated: 31 Dec 1969

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Renal resistive index and aortic knob width relationship as a predictor of renal prognosis in essential hypertension.
 

Author(s): Nurhayat Ozkan Sevencan, Aysegul Ertinmaz Ozkan

Journal: Medicine (Baltimore). 2018 Oct;97(40):e12434.

 

The scientific studies that have been conducted so far highlight that renal resistive index (RI) and aortic knob width (AKW) indicate poor prognosis regarding renal and cardiovascular mortality. But the existence of a direct relationship RI and AKW is unclear. This study aims investigating ...

Last Updated: 31 Dec 1969

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Quantitative evaluation of myocardial layer-specific strain using two-dimensional speckle tracking echocardiography among young adults with essential hypertension in China.
 

Author(s): Liangjie Xu, Ning Wang, Xinxin Chen, Yi Liang, Hong Zhou, Jinchuan Yan

Journal: Medicine (Baltimore). 2018 Sep;97(39):e12448.

 

The myocardial wall of the left ventricle is a complex, multilayered structure, which is altered in young adults with hypertension. The aim of this study was to define the characteristics of longitudinal and circumferential strain in young adults with hypertension.Two-dimensional ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Essential hypertension" returned 93 free, full-text review articles on human participants. First 3 results:

Tianma Gouteng decoction for essential hypertension: Protocol for a systematic review and meta-analysis.
 

Author(s): Benjian Chen, Yuanping Wang, Zhuogen He, Dawei Wang, Xia Yan, Pingchang Xie

Journal: Medicine (Baltimore). 2018 Feb;97(8):e9972.

 

Essential hypertension is one of the most common chronic diseases, as well as one of the leading risk factors for cardio-cerebrovascular diseases. Tianma Gouteng decoction has been commonly used in clinical practice for patients with essential hypertension. It is important to update ...

Last Updated: 31 Dec 1969

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The Impact of Vitamin D in the Treatment of Essential Hypertension.
 

Author(s): Christian Legarth, Daniela Grimm, Markus Wehland, Johann Bauer, Marcus Kr├╝ger

Journal:

 

The aim of this review is to investigate, whether there is a possible link between vitamin D supplementation and the reduction of blood pressure in hypertensive patients. The renin-angiotensin-aldosterone system is known for being deeply involved in cardiovascular tonus and blood ...

Last Updated: 31 Dec 1969

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Inflammation, Autoimmunity, and Hypertension: The Essential Role of Tissue Transglutaminase.
 

Author(s): Chen Liu, Rodney E Kellems, Yang Xia

Journal: Am. J. Hypertens.. 2017 Aug;30(8):756-764.

 

Inflammatory cytokines cause hypertension when introduced into animals. Additional evidence indicates that cytokines induce the production of autoantibodies that activate the AT1 angiotensin receptor (AT1R). Extensive evidence shows that these autoantibodies, termed AT1-AA, contribute ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

A Registry Study on Biomarkers in Essential Hypertension
 

Status: Not yet recruiting

Condition Summary: Essential Hypertension

 

Last Updated: 13 Oct 2018

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Renal Sympathetic Modification in Patients With Essential Hypertension
 

Status: Recruiting

Condition Summary: Essential Hypertension

 

Last Updated: 13 Jul 2017

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Last Updated: 18 Jan 2018

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