Evans Syndrome

Common Name(s)

Evans Syndrome

Evans syndrome is a very rare autoimmune disorder in which the immune system destroys the body's red blood cells, white blood cells and/or platelets. Affected people often experience thrombocytopenia (too few platelets) and Coombs' positive hemolytic anemia (premature destruction of red blood cells). Signs and symptoms may include purpura, paleness, fatigue, and light-headedness.The exact cause of this condition is unknown. The best treatment options for Evans syndrome depend on many factors, including the severity of the condition; the signs and symptoms present; and each person's response to certain therapies.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Evans Syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Evans Syndrome" returned 46 free, full-text research articles on human participants. First 3 results:

Isolated non-traumatic, non-aneurysmal convexal subarachnoid hemorrhage in a patient with Evans syndrome.
 

Author(s): Anna Misyail Abdul Rashid, Mohamad Syafeeq Faeez Md Noh

Journal:

 

Non-traumatic, spontaneous subarachnoid hemorrhage occurs in approximately 85% of cases where there is a ruptured saccular aneurysm. An additional 10% of cases arise from non-aneurysmal peri-mesencephalic hemorrhages.

Last Updated: 31 Dec 1969

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Paraneoplastic Evans syndrome in a patient with adenocarcinoma of the lung: A case report.
 

Author(s): Hong Yu, Rong Fu, Huaquan Wang, Hui Liu, Zonghong Shao

Journal: Thorac Cancer. 2017 Jan;8(1):57-60.

 

We present a rare case of newly diagnosed Evans syndrome associated with lung papillary adenocarcinoma in which the patient showed prompt restoration of blood cell count and long-lasting complete remission of Evans syndrome after lung cancer resection. Detailed investigation led to ...

Last Updated: 31 Dec 1969

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Evans syndrome with non-ST segment elevation myocardial infarction complicated by hemopericardium.
 

Author(s): Filiz Kizilirmak, Gultekin Gunhan Demir, Beytullah Cakal, Hüseyin Saffet Bekoz, Fatih Erkam Olgun

Journal: Indian Heart J. 2016 Sep;68 Suppl 2():S280-S283.

 

Evans syndrome (ES) is a rare hematological disease characterized by autoimmune hemolytic anemia, immune thrombocytopenia, and/or neutropenia, all of which may be seen simultaneously or subsequently. Thrombotic events in ES are uncommon. Furthermore, non-ST segment-elevation myocardial ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Evans Syndrome" returned 8 free, full-text review articles on human participants. First 3 results:

Treatment of refractory ITP and Evans syndrome by haematopoietic cell transplantation: is it indicated, and for whom?
 

Author(s): J E Vaughn, F Anwer, H J Deeg

Journal: Vox Sang.. 2016 Jan;110(1):5-11.

 

Several lines of therapy have been established for patients with immune thrombocytopenia (ITP) and Evans syndrome. However, these therapies generally require prolonged administration, lead to profound immunosuppression and increased infectious risk, and are often poorly tolerated. ...

Last Updated: 31 Dec 1969

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CD56+ angioimmunoblastic T-cell lymphoma with evans syndrome : a case report and review of the literature.
 

Author(s): Yasunobu Sekiguchi, Asami Shimada, Hidenori Imai, Mutsumi Wakabayashi, Keiji Sugimoto, Noriko Nakamura, Tomonori Sawada, Norio Komatsu, Masaaki Noguchi

Journal: J Clin Exp Hematop. 2013 ;53(1):37-47.

 

A 67-year-old man was diagnosed with CD56(+) angioimmunoblastic T cell lymphoma (AITL), which was associated with autoimmune thrombocytopenic purpura (ATP) and autoimmune hemolytic anemia (AIHA) (Evans syndrome). The ATP was refractory to Helicobacter pylori eradication therapy and ...

Last Updated: 31 Dec 1969

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Rituximab for refractory Evans syndrome and other immune-mediated hematologic diseases.
 

Author(s): Elpis Mantadakis, Vassiliki Danilatou, Eftichia Stiakaki, Maria Kalmanti

Journal: Am. J. Hematol.. 2004 Nov;77(3):303-10.

 

The authors describe a 21-year-old man with long-lasting Evans syndrome refractory to corticosteroids and immunosuppressive agents; the patient responded to four weekly infusions of rituximab. The patient relapsed with thrombocytopenia 7 months post-therapy and was successfully re-treated ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Severe Immune Cytopenia Registry Www.Sic-reg.Org
 

Status: Recruiting

Condition Summary: Immune Thrombocytopenia; Autoimmune Hemolytic Anemia; Evan Syndrome; Primary Immunodeficiency

 

Last Updated: 21 Jun 2018

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