Familial renal glucosuria

Common Name(s)

Familial renal glucosuria

Patients with familial renal glucosuria have decreased renal tubular resorption of glucose form the urine in the absence of hyperglycemia and any other signs of tubular dysfunction. Glucosuria in these patients can range from less than 1 to over 150 g/1.73 m(2) per day ({13:Santer and Calado, 2010}).
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Familial renal glucosuria" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Familial renal glucosuria" returned 1 free, full-text research articles on human participants. First 3 results:

Familial renal glucosuria: SLC5A2 mutation analysis and evidence of salt-wasting.
 

Author(s): J Calado, J Loeffler, O Sakallioglu, F Gok, K Lhotta, J Barata, J Rueff

Journal: Kidney Int.. 2006 Mar;69(5):852-5.

 

Familial renal glucosuria (FRG) is an inherited renal tubular disorder characterized by persistent isolated glucosuria in the absence of hyperglycemia. Mutations in the sodium/glucose co-transporter SGLT2 coding gene, SLC5A2, were recently found to be responsible for the disorder. ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Familial renal glucosuria" returned 2 free, full-text review articles on human participants. First 3 results:

[Sodium-glucose cotransporter type 2 inhibitors (SGLT2): from familial renal glucosuria to the treatment of type 2 diabetes mellitus].
 

Author(s): G Pérez López, O González Albarrán, M Cano Megías

Journal: Nefrologia. 2010 ;30(6):618-25.

 

For centuries, the kidney has been considered primarily an organ of elimination and a regulator of salt and ion balance. Although once thought that the kidney was the structural cause of diabetes, which in recent years has been ignored as a regulator of glucose homeostasis, is now ...

Last Updated: 31 Dec 1969

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Familial renal glucosuria and SGLT2: from a mendelian trait to a therapeutic target.
 

Author(s): René Santer, Joaquim Calado

Journal: Clin J Am Soc Nephrol. 2010 Jan;5(1):133-41.

 

Four members of two glucose transporter families, SGLT1, SGLT2, GLUT1, and GLUT2, are differentially expressed in the kidney, and three of them have been shown to be necessary for normal glucose resorption from the glomerular filtrate. Mutations in SGLT1 are associated with glucose-galactose ...

Last Updated: 31 Dec 1969

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