Fetal aminopterin syndrome is a condition affecting babies whose mothers were exposed to the chemical aminopterin or methotraxate during pregnancy. Only about 50 cases have been reported. Babies exposed to aminopterin or methotraxate during development can be born with developmental delays such as inability to properly grow, abnormal arms or legs, and changes to the face or skull. Symptoms of fetal aminopterin syndrome depend on how early in pregnancy the woman is exposed to aminopterin or methotraxate and the dosage of the medication being used. There is no cure for fetal aminopterin syndrome, though symptoms can be managed. Aminopterin is no longer used, but methotraxate may still be used to treat some conditions such as cancer. Pregnant women should consult a physician before taking medications with either chemical.