Gallbladder cancer

Common Name(s)

Gallbladder cancer

Gallbladder cancer is a type of cancer that begins in the gallbladder, an organ under the liver in the upper abdomen. The gallbladder stores bile, which is made by the liver for fat digestion. Signs of gallbladder cancer include yellowing of the skin or eyes (jaundice), pain in the upper right part of the abdomen, fever, nausea, vomiting, bloating, weight loss, loss of appetite, itchiness, and lumps in the abdomen.

Gallbladder cancer occurs when cells in the gallbladder develop mutations that result in the cells dividing rapidly and resisting death. Those cells form a tumor. Being female and being Native American increases one’s risk of developing gallbladder cancer. Other risk factors include being older, obesity, and having a history of gallstones.

Because the symptoms are consistent with those of many other diseases, gallbladder cancer is difficult to detect early. With that said, there are several tests used to diagnose gallbladder cancer. High levels of a chemical in bile called bilirubin are a sign of gallbladder cancer and can be detected through blood tests. Tumor markers, or proteins that present in the blood with certain cancers, may also be detected by blood tests. X-ray imaging, computed tomography (CT) scans, magnetic resonance imaging (MRI) scans, and ultrasounds can also be used to diagnose gallbladder cancer. Additional tests may be performed to determine the stage of the disease.

Treatment for gallbladder cancer often involves surgical removal of the gallbladder and surrounding tissues in a procedure called a cholecystectomy. If the cancer cannot be removed, symptoms may be lessened through additional surgery, chemotherapy, radiation therapy, or clinical trials. If you have been diagnosed with gallbladder cancer, talk to your doctor about the most current treatment options. Support groups are available for more resources and information.

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Condition Specific Organizations

Following organizations serve the condition "Gallbladder cancer" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Gallbladder cancer" returned 331 free, full-text research articles on human participants. First 3 results:

Gallbladder cancer with tumor thrombus in the portal vein: A case report.
 

Author(s): Xiao-Zhen Zhang, Jian-Jun Tu, Wei Chen, Tao Ma, Xue-Li Bai, Ting-Bo Liang

Journal: Medicine (Baltimore). 2018 Apr;97(16):e0271.

 

Gallbladder cancer (GBC) is a highly fatal malignancy. Due to its invasiveness and delayed diagnosis, many GBC patients are diagnosed with synchronous liver and hepatoduodenal ligament involvement. In our case, we report a gallbladder cancer with portal vein thrombus.

Last Updated: 31 Dec 1969

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Tea polyphenols induce S phase arrest and apoptosis in gallbladder cancer cells.
 

Author(s): Jiaqi Wang, Yixuan Pan, Jiacheng Hu, Qiang Ma, Yi Xu, Yijian Zhang, Fei Zhang, Yingbin Liu

Journal:

 

Gallbladder cancer (GBC) is the most common malignancy in the biliary tract. Without effective treatment, its prognosis is notoriously poor. Tea polyphenols (TPs) have many pharmacological and health benefits, including antioxidant, anti-inflammatory, anti-tumor, anti-thrombotic, ...

Last Updated: 31 Dec 1969

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Prognostic significance of promoter DNA hypermethylation of the cysteine dioxygenase 1 (CDO1) gene in primary gallbladder cancer and gallbladder disease.
 

Author(s): Kazuharu Igarashi, Keishi Yamashita, Hiroshi Katoh, Keita Kojima, Yosuke Ooizumi, Nobuyuki Nishizawa, Ryo Nishiyama, Hiroshi Kawamata, Hiroshi Tajima, Takashi Kaizu, Yusuke Kumamoto, Masahiko Watanabe

Journal:

 

Aberrant promoter DNA methylation of the cysteine dioxygenase 1 (CDO1) gene is found in various human cancers and is associated with clinical outcome. In this study, we assessed for the first time the clinicopathological significance of CDO1 methylation in primary gallbladder cancer ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Gallbladder cancer" returned 33 free, full-text review articles on human participants. First 3 results:

Biofilm Producing Salmonella Typhi: Chronic Colonization and Development of Gallbladder Cancer.
 

Author(s): Enea Gino Di Domenico, Ilaria Cavallo, Martina Pontone, Luigi Toma, Fabrizio Ensoli

Journal:

 

subspecies serovar Typhi is the aetiological agent of typhoid or enteric fever. In a subset of individuals, . Typhi colonizes the gallbladder causing an asymptomatic chronic infection. Nonetheless, these asymptomatic carriers provide a reservoir for further spreading of the disease. ...

Last Updated: 31 Dec 1969

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Contrast-enhanced harmonic endoscopic ultrasonography in gallbladder cancer and pancreatic cancer.
 

Author(s): Mitsuru Sugimoto, Tadayuki Takagi, Rei Suzuki, Naoki Konno, Hiroyuki Asama, Ko Watanabe, Jun Nakamura, Hitomi Kikuchi, Yuichi Waragai, Mika Takasumi, Yuki Sato, Takuto Hikichi, Hiromasa Ohira

Journal: Fukushima J Med Sci. 2017 Aug;63(2):39-45.

 

Endoscopic ultrasonography (EUS) plays a major role in diagnosing gallbladder (GB) cancer and pancreatic cancer (PC). In cases of GB cancer, EUS allows for precise observations of morphology and wall layers. However, proficiency is required for the morphologic diagnosis of GB tumors. ...

Last Updated: 31 Dec 1969

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Gallbladder cancer epidemiology, pathogenesis and molecular genetics: Recent update.
 

Author(s): Aarti Sharma, Kiran Lata Sharma, Annapurna Gupta, Alka Yadav, Ashok Kumar

Journal: World J. Gastroenterol.. 2017 Jun;23(22):3978-3998.

 

Gallbladder cancer is a malignancy of biliary tract which is infrequent in developed countries but common in some specific geographical regions of developing countries. Late diagnosis and deprived prognosis are major problems for treatment of gallbladder carcinoma. The dramatic associations ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

The Effect in Wedge Resection and IVb/V Resection of the Liver for Gallbladder Cancer
 

Status: Recruiting

Condition Summary: Gallbladder Cancer

 

Last Updated: 28 Sep 2016

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Last Updated: 13 Aug 2016

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Three Dimension Laparoscopic Versus Open Surgery for Gallbladder Carcinoma
 

Status: Not yet recruiting

Condition Summary: Gallbladder Cancer; Surgery

 

Last Updated: 1 Apr 2018

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