Gastroesophageal reflux disease

Common Name(s)

Gastroesophageal reflux disease, GERD

Gastroesophageal reflux disease, or GERD, is caused by frequent acid reflux, which irritates the lining of the esophagus. GERD is generally diagnosed when a person experiences acid reflux more than two times per week.

Acid reflux is a common condition in which stomach acid flows up into the esophagus. This causes a burning, painful feeling in the chest more commonly known as heartburn or acid indigestion. Your stomach makes a strong acid to help break down food and to protect you from bacteria. The stomach is not harmed by the acid because it has a special lining. The esophagus is the tube that takes your food from your mouth to your stomach. It does not have the special lining, so it will be irritated by the stomach acid. Normally a special ring of muscle, the lower esophageal sphincter (LES), keeps the stomach’s contents from flowing up into the esophagus. Acid reflux happens most often when the LES is not working correctly.

Symptoms of acid reflux include heartburn, bitter or sour taste in the mouth, difficulty swallowing, a chronic dry cough, wheezing and hoarseness. The heartburn usually occurs after a meal, lasts several hours and worsens if you lie down. Although it is not clear what causes the LES to weaken, certain factors seem to increase the risk of developing acid reflux including obesity, pregnancy, having a hiatal hernia, smoking, drinking alcohol and caffeine, and taking certain medications. Certain types of foods may trigger an heartburn episode.

Risk factors for GERD include obesity, pregnancy, smoking, dry mouth, asthma, diabetes, and connective tissue disorders. If you are experiencing frequent acid reflux, making lifestyle changes to lower your risks may help so that GERD is not developed. If you believe you may have GERD, or if you are experiencing acid reflux frequently, seek medical attention. Support groups are available for more resources and information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Gastroesophageal reflux disease" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Gastroesophageal reflux disease" returned 455 free, full-text research articles on human participants. First 3 results:

Peroral endoscopic cardial constriction in gastroesophageal reflux disease.
 

Author(s): Hai-Qing Hu, Hui-Kai Li, Ying Xiong, Xiao-Bin Zhang, Jun-Li Zhi, Xiao-Xiao Wang, En-Qiang Ling-Hu

Journal: Medicine (Baltimore). 2018 Apr;97(15):e0169.

 

Gastroesophageal reflux disease (GERD) is a major digestive health problem with a high and increasing incidence worldwide. Peroral endoscopic cardial constriction (PECC) was developed by our group to provide a less invasive treatment for GERD.In this preliminary follow-up study, 16 ...

Last Updated: 31 Dec 1969

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Decline in perception of acid regurgitation symptoms from gastroesophageal reflux disease in diabetes mellitus patients.
 

Author(s): Kosuke Sakitani, Nobumi Suzuki, Sozaburo Ihara, Yoshihiro Hirata, Shoji Kawazu, Yasuhiko Iwamoto, Kazuhiko Koike

Journal:

 

To determine if a discrepancy exists between subjective symptoms and the grade of endoscopic gastroesophageal reflux disease (GERD) in diabetes mellitus (DM) patients.

Last Updated: 31 Dec 1969

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Streptococcus agalactiae meningoencephalitis associated with gastroesophageal reflux disease and chronic proton pump inhibitors use, in a 9 month-old infant: a case report.
 

Author(s): Victoria Bîrluţiu, Codruța Mihaela Luca, Rareș-Mircea Bîrluțiu

Journal:

 

Streptococcus agalactiae (Group B Streptococcus) is recognized as the etiologic agent of newborn and infant meningitis, aged up to 90 days, starting from the colonization of the maternal genital or gastrointestinal tract, but it is rarely responsible for meningitis in old infants.

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Gastroesophageal reflux disease" returned 135 free, full-text review articles on human participants. First 3 results:

New Minimally Invasive Endoscopic and Surgical Therapies for Gastroesophageal Reflux Disease (GERD).
 

Author(s): Alexandru Eugen Nicolau, Adrian Lobonţiu, Silviu Constantinoiu

Journal: Chirurgia (Bucur). ;113(1):70-82.

 

GERD has become one of the most frequent pathology of the upper GI tract. It is a spectrum disease and is a progressive disease as well. Serious and severe complications are possible. The mainstream therapy in most of the patients is the medical therapy with PPI's. The most severe ...

Last Updated: 31 Dec 1969

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What is proton pump inhibitors unresponsiveness in gastroesophageal reflux disease? How should these cases be managed?
 

Author(s): Altay Çelebi, Hasan Yılmaz

Journal: Turk J Gastroenterol. 2017 12;28(Suppl 1):S71-S72.

 

Proton pump inhibitors become the most potent therapeutic option in gastroesophageal reflux disease. Unresponsiveness to this treatment is not uncommon in clinical practice. We reviewed the definition of PPI unresponsiveness and the management of this situation.

Last Updated: 31 Dec 1969

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Gastroesophageal reflux disease and the relationship with Helicobacter pylori.
 

Author(s): Zeynel Mungan, Binnur Pınarbaşı Şimşek

Journal: Turk J Gastroenterol. 2017 12;28(Suppl 1):S61-S67.

 

After Helicobacter pylori was identified, and its relationship with peptic ulcer disease was exactly shown, the relationship of this bacterium with gastroesophageal reflux disease (GERD) gained momentum and discussions continue to this day. We reviewed the literature for the relationship ...

Last Updated: 31 Dec 1969

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Symptom Assessment for Patients With Gastro-esophageal Reflux Disease Receiving Helicobacter Pylori Eradication
 

Status: Not yet recruiting

Condition Summary: Gastroesophageal Reflux Disease

 

Last Updated: 17 Oct 2016

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Impact of Head of Bed Elevation in Symptoms of Patients With Gastroesophageal Reflux Disease
 

Status: Recruiting

Condition Summary: Gastroesophageal Reflux Disease

 

Last Updated: 25 Oct 2016

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