Gianotti-Crosti syndrome, also known as papulovesicular acrodermatitis of childhood, papular acrodermatitis of childhood or acrodermatitis papulosa infantum, is a skin rash caused by a viral infection. The rash develops as dull red spots develops over 3 or 4 days. They appear first on the thighs and buttocks, then on the outer aspects of the arms and finally on the face, often in an asymmetrical pattern. The spots vary in size. Later the rash often looks purple, especially on the legs. The spots may develop fluid-filled blisters. The specific viruses causing Gianotti-Crosti syndrome include: hepatitis B, Epstein Barr, enterovirus, echo and respiratory syncytial virus. A person with Gianotti-Crosti syndrome may also have a low fever and a general feeling of discomfort.
Gianotti-Crosti syndrome mainly affects children between the ages of 6 months and 12 years. A clustering of cases is often observed. Often the child will have an upper respiratory infection before having the rash.
The rash fades in 2-8 weeks with mild scaling. Depending on the virus which caused the rash further treatment may be needed.
Recurrence of the Gianotti-Crosti syndrome is unlikely but has been reported.