Gray zone lymphoma

Common Name(s)

Gray zone lymphoma

Gray zone lymphoma is a cancer of the immune system.  The name of this lymphoma refers to the fact that cancer cells in this condition are in a "gray zone" (an uncertain category) because they appear similar to that of two other types of lymphoma, classical Hodgkin lymphoma and mediastinal large B-cell lymphoma.  Because features of gray zone lymphoma overlap with these two other types of lymphoma, diagnosing this condition can be difficult.  Gray zone lymphoma is most often diagnosed in young adults when an unusual lump (mass) is found in the chest in the space between the lungs (mediastinum).  This condition affects men and women equally.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Gray zone lymphoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Gray zone lymphoma" returned 12 free, full-text research articles on human participants. First 3 results:

PD-1 Blockade in Mediastinal Gray-Zone Lymphoma.
 

Author(s): Christopher Melani, Ajay Major, Jeffrey Schowinsky, Mark Roschewski, Stefania Pittaluga, Elaine S Jaffe, Svetlana D Pack, Zied Abdullaev, Mark A Ahlman, Jennifer J Kwak, Rustain Morgan, Rachel Rabinovitch, Zenggang Pan, Bradley M Haverkos, Jonathan A Gutman, Daniel A Pollyea, Clayton A Smith, Wyndham H Wilson, Manali Kamdar

Journal: N. Engl. J. Med.. 2017 07;377(1):89-91.

 

Last Updated: 31 Dec 1969

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Management of Primary Mediastinal B-Cell Lymphoma and Gray Zone Lymphoma.
 

Author(s): Kieron Dunleavy

Journal: Oncology (Williston Park, N.Y.). 2017 06;31(6):499-501.

 

Primary mediastinal B-cell lymphoma is a distinct clinicopathologic entity that has a predilection for young women. It is clinically and molecularly different from other subtypes of diffuse large B-cell lymphoma and has a unique paradigm of management. While the cure rate for patients ...

Last Updated: 31 Dec 1969

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Gray-zone lymphoma: a complex reality.
 

Author(s): Bushra Moiz, Ayesha Majeed

Journal: Blood. 2016 06;127(26):3459.

 

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Gray zone lymphoma" returned 1 free, full-text review articles on human participants. First 3 results:

Primary mediastinal B-cell lymphoma and mediastinal gray zone lymphoma: do they require a unique therapeutic approach?
 

Author(s): Kieron Dunleavy, Wyndham H Wilson

Journal: Blood. 2015 Jan;125(1):33-9.

 

Primary mediastinal B-cell lymphoma (PMBL) is a subtype of diffuse large B-cell lymphoma (DLBCL) that is putatively derived from a thymic B cell. Accounting for up to 10% of cases of DLBCL, this subtype predominantly affects women in the third and fourth decades of life. Its clinical ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Pembrolizumab in Relapsed and Refractory Gray-Zone Lymphoma (GZL), Primary Central Nervous System Lymphoma (PCNSL), and Other Extranodal Diffuse Large B-cell Lymphomas
 

Status: Recruiting

Condition Summary: Non-Hodgkin Lymphoma; Lymphoma; Diffuse Large B-Cell Lymphoma; Gray Zone Lymphoma; Primary Central Nervious System Lymphoma

 

Last Updated: 11 Jul 2018

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Dose-Adjusted EPOCH Chemotherapy and Rituximab (CD20+) in Previously Untreated Aggressive Non-Hodgkin's Lymphoma
 

Status: Recruiting

Condition Summary: Diffuse Large B-Cell Lymphoma (DLBCL); Primary Mediastinal Large B-cell Lymphoma; Burkitt Lymphoma; Anaplastic Large-Cell Lymphoma; Gray Zone Lymphoma

 

Last Updated: 10 Aug 2018

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Haploidentical BMT With Post-Transplant Cyclophosphamide and Bendamustine
 

Status: Recruiting

Condition Summary: Acute Lymphoblastic Leukemia; Acute Myelogenous Leukemia; Myelodysplastic Syndromes; Chronic Myelogenous Leukemia; Juvenile Myelomonocytic Leukemia; Lymphoma,Non-Hodgkin; Lymphoma, Hodgkin; Lymphoma, Follicular; Marginal Zone Lymphoma; Large Cell Lymphoma; Mantle-Cell Lymphoma; Gray Zone Lymphoma; Burkitt Lymphoma

 

Last Updated: 27 Jun 2018

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