HTLV-1 associated myelopathy/tropical spastic paraparesis

Common Name(s)

HTLV-1 associated myelopathy/tropical spastic paraparesis

HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic, progressive disease of the nervous system that affects less than 2 percent of people with HTLV-1 infection. Signs and symptoms vary but may include progressive weakness, stiff muscles, muscle spasms, backache, a 'weak' bladder, and constipation. The HTLV-1 virus can be transmitted from mother to child via breastfeeding or childbirth, from person to person through sexual contact and through blood contact, either by transfusion or by reuse of injection equipment. HTLV infection is not passed from person to person by coughing, sneezing, kissing, cuddling or daily social contact. Screening of donated blood for HTLV-1 has been done in the United States since 1988.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "HTLV-1 associated myelopathy/tropical spastic paraparesis" for support, advocacy or research.

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The STD Project

Established in April of 2012 during STD Awareness Month, The STD Project is a multi-award-winning independent website and progressive movement eradicating STD stigma by facilitating and encouraging awareness, education, and acceptance through story-telling and resource recommendations. We are taking steps toward modern-day sexual health and prevention by advocating for conscientious and informed decisions.

Last Updated: 11 Jul 2016

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "HTLV-1 associated myelopathy/tropical spastic paraparesis" for support, advocacy or research.

Logo
The STD Project

Established in April of 2012 during STD Awareness Month, The STD Project is a multi-award-winning independent website and progressive movement eradicating STD stigma by facilitating and encouraging awareness, education, and acceptance through story-telling and resource recommendations. We are taking steps toward modern-day sexual health and prevention by advocating for conscientious and informed decisions.

http://www.thestdproject.com/

Last Updated: 11 Jul 2016

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "HTLV-1 associated myelopathy/tropical spastic paraparesis" returned 34 free, full-text research articles on human participants. First 3 results:

Temporal trends in Human T-Lymphotropic virus 1 (HTLV-1) associated myelopathy/tropical spastic paraparesis (HAM/TSP) incidence in Martinique over 25 years (1986-2010).
 

Author(s): Stephane Olindo, Severine Jeannin, Martine Saint-Vil, Aissatou Signate, Mireille Edimonana-Kaptue, Julien Joux, Harold Merle, Pascale Richard, Samuel Granjeaud, Philippe Cabre, Didier Smadja, Raymond Cesaire, Agnes Lezin

Journal:

 

Human T-lymphotropic virus type 1 (HTLV-1) has been discovered in 1980 and has been linked to tropical spastic paraparesis (HAM/TSP) in 1985 in Martinique. There is no data on HAM/TSP incidence trends. We report, in the present work, the temporal trends incidence of HAM/TSP in Martinique ...

Last Updated: 31 Dec 1969

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The CC chemokine ligand (CCL) 1, upregulated by the viral transactivator Tax, can be downregulated by minocycline: possible implications for long-term treatment of HTLV-1-associated myelopathy/tropical spastic paraparesis.
 

Author(s): Mineki Saito, Hiroe Sejima, Tadasuke Naito, Hiroshi Ushirogawa, Toshio Matsuzaki, Eiji Matsuura, Yuetsu Tanaka, Tatsufumi Nakamura, Hiroshi Takashima

Journal:

 

Chemokine (C-C motif) ligand 1 (CCL1) is produced by activated monocytes/ macrophages and T-lymphocytes, and acts as a potent attractant for Th2 cells and a subset of T-regulatory (Treg) cells. Previous reports have indicated that CCL1 is overexpressed in adult T-cell leukemia cells, ...

Last Updated: 31 Dec 1969

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Effects of host restriction factors and the HTLV-1 subtype on susceptibility to HTLV-1-associated myelopathy/tropical spastic paraparesis.
 

Author(s): Satoshi Nozuma, Eiji Matsuura, Daisuke Kodama, Yuichi Tashiro, Toshio Matsuzaki, Ryuji Kubota, Shuji Izumo, Hiroshi Takashima

Journal:

 

Although human T-lymphotropic virus type 1 (HTLV-1) infection is a prerequisite for the development of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), specific provirus mutations in HAM/TSP have not yet been reported. In this study, we examined whether HAM/TSP ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "HTLV-1 associated myelopathy/tropical spastic paraparesis" returned 0 free, full-text review articles on human participants.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Evaluation of Patients With HAM/TSP
 

Status: Recruiting

Condition Summary: HTLV-I Infection; Tropical Spastic Paraparesis

 

Last Updated: 26 Jun 2018

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Effect of Raltegravir in Patients With Acute Tropical Spastic Paraparesis - Human T-Lymphotropic Virus 1 Infection
 

Status: Recruiting

Condition Summary: HTLV-I Infections; Tropical Spastic Paraparesis

 

Last Updated: 20 Nov 2017

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