Hairy Cell Leukemia

Common Name(s)

Hairy Cell Leukemia

Hairy cell leukemia is a rare, slow-growing cancer of the blood in which the bone marrow makes too many B cells (lymphocytes), a type of white blood cell that fights infection. The condition is named after these excess B cells which look 'hairy' under a microscope. As the number of leukemia cells increases, fewer healthy white blood cells, red blood cells and platelets are produced. The underlying cause of this condition is unknown. While there is no cure, treatment can lead to remission which can last for years.   
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hairy Cell Leukemia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hairy Cell Leukemia" returned 312 free, full-text research articles on human participants. First 3 results:

Hairy cell leukemia 2018: Update on diagnosis, risk-stratification, and treatment.
 

Author(s): Xavier Troussard, Edouard Cornet

Journal: Am. J. Hematol.. 2017 Dec;92(12):1382-1390.

 

Hairy cell leukemia (HCL) and HCL-like disorders, including HCL variant (HCL-V) and splenic diffuse red pulp lymphoma (SDRPL), are a very heterogeneous group of mature lymphoid B-cell disorders, characterized by the identification of hairy cells, a specific genetic profile, a different ...

Last Updated: 31 Dec 1969

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Time to Cure Hairy Cell Leukemia.
 

Author(s): Ilana Levy, Tamar Tadmor

Journal: Turk J Haematol. 2017 12;34(4):289-290.

 

Last Updated: 31 Dec 1969

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Genomic analysis of hairy cell leukemia identifies novel recurrent genetic alterations.
 

Author(s): Benjamin H Durham, Bartlomiej Getta, Sascha Dietrich, Justin Taylor, Helen Won, James M Bogenberger, Sasinya Scott, Eunhee Kim, Young Rock Chung, Stephen S Chung, Jennifer Hüllein, Tatjana Walther, Lu Wang, Sydney X Lu, Christopher C Oakes, Raoul Tibes, Torsten Haferlach, Barry S Taylor, Martin S Tallman, Michael F Berger, Jae H Park, Thorsten Zenz, Omar Abdel-Wahab

Journal: Blood. 2017 10;130(14):1644-1648.

 

Classical hairy cell leukemia (cHCL) is characterized by a near 100% frequency of the V600E mutation, whereas ∼30% of variant HCLs (vHCLs) have mutations. However, recurrent genetic alterations cooperating with V600E or mutations in HCL, as well as those in wild-type vHCL, are ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hairy Cell Leukemia" returned 20 free, full-text review articles on human participants. First 3 results:

Genomics of Hairy Cell Leukemia.
 

Author(s): Enrico Tiacci, Valentina Pettirossi, Gianluca Schiavoni, Brunangelo Falini

Journal: J. Clin. Oncol.. 2017 Mar;35(9):1002-1010.

 

Hairy cell leukemia (HCL) is a chronic mature B-cell neoplasm with unique clinicopathologic features and an initial exquisite sensitivity to chemotherapy with purine analogs; however, the disease relapses, often repeatedly. The enigmatic pathogenesis of HCL was recently clarified ...

Last Updated: 31 Dec 1969

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Consensus guidelines for the diagnosis and management of patients with classic hairy cell leukemia.
 

Author(s): Michael R Grever, Omar Abdel-Wahab, Leslie A Andritsos, Versha Banerji, Jacqueline Barrientos, James S Blachly, Timothy G Call, Daniel Catovsky, Claire Dearden, Judit Demeter, Monica Else, Francesco Forconi, Alessandro Gozzetti, Anthony D Ho, James B Johnston, Jeffrey Jones, Gunnar Juliusson, Eric Kraut, Robert J Kreitman, Loree Larratt, Francesco Lauria, Gerard Lozanski, Emili Montserrat, Sameer A Parikh, Jae H Park, Aaron Polliack, Graeme R Quest, Kanti R Rai, Farhad Ravandi, Tadeusz Robak, Alan Saven, John F Seymour, Tamar Tadmor, Martin S Tallman, Constantine Tam, Enrico Tiacci, Xavier Troussard, Clive S Zent, Thorsten Zenz, Pier Luigi Zinzani, Brunangelo Falini

Journal: Blood. 2017 02;129(5):553-560.

 

Hairy cell leukemia is an uncommon hematologic malignancy characterized by pancytopenia and marked susceptibility to infection. Tremendous progress in the management of patients with this disease has resulted in high response rates and improved survival, yet relapse and an appropriate ...

Last Updated: 31 Dec 1969

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BRAF V600E mutation in hairy cell leukemia: from bench to bedside.
 

Author(s): Brunangelo Falini, Maria Paola Martelli, Enrico Tiacci

Journal: Blood. 2016 10;128(15):1918-1927.

 

Hairy cell leukemia (HCL) is a distinct clinicopathological entity whose underlying genetic lesion has remained a mystery for over half a century. The BRAF V600E mutation is now recognized as the causal genetic event of HCL because it is somatic, present in the entire tumor clone, ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Therapy Optimisation for the Treatment of Hairy Cell Leukemia
 

Status: Recruiting

Condition Summary: Hairy Cell Leukemia

 

Last Updated: 11 Jan 2018

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Cladribine With Simultaneous or Delayed Rituximab to Treat Hairy Cell Leukemia
 

Status: Recruiting

Condition Summary: Hairy Cell Leukemia

 

Last Updated: 13 Jul 2018

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