Hairy Cell Leukemia

Common Name(s)

Hairy Cell Leukemia

Hairy cell leukemia is a rare, slow-growing cancer of the blood in which the bone marrow makes too many B cells (lymphocytes), a type of white blood cell that fights infection. The condition is named after these excess B cells which look 'hairy' under a microscope. As the number of leukemia cells increases, fewer healthy white blood cells, red blood cells and platelets are produced. The underlying cause of this condition is unknown. While there is no cure, treatment can lead to remission which can last for years.   
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Advocacy and Support Organizations Health Questions Recommended Apps Scientific Literature Symptoms, Diagnosis, and Treatment Clinical Trial Information
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hairy Cell Leukemia" for support, advocacy or research.

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How do you compare to others with this condition?

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Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hairy Cell Leukemia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
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Recommended Apps

Privately answer questions about your health. Let resources, you select, come to you

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

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Relief is when you and the right researcher find each other

Finding the right clinical trial for Hairy Cell Leukemia can be challenging. However, with TrialsFinder (which uses the Reg4ALL database and privacy controls by Private Access), you can permit researchers to let you know opportunities to consider - all without revealing your identity.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hairy Cell Leukemia" returned 317 free, full-text research articles on human participants. First 3 results:

Atypical presentation of hairy cell leukemia: Significance of CD200 on flow cytometry.
 

Author(s): Khaliqur Rahman, Surabhi Kumari, Manish Kumar Singh, Ruchi Gupta, Geeta Yadav, Neeraj Kumari, Soniya Nityan

Journal: J Cancer Res Ther. ;14(5):1130-1134.

 

Hairy cell leukemia (HCL) is a rare, low-grade mature B-cell neoplasm with a characteristic clinical, morphological, immunophenotypic, and more recently described molecular (BRAF p.V600E mutation) profile. It typically affects middle-aged to elderly male who present with pancytopenia ...

Last Updated: 31 Dec 1969

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Hairy cell leukemia presenting with progressive pericarditis and pleuritis.
 

Author(s): Atsushi Iwashige, Makoto Hirosawa, Junichi Tsukada

Journal: Ann. Hematol.. 2018 Dec;97(12):2527-2528.

 

Last Updated: 31 Dec 1969

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Neutropenia caused by hairy cell leukemia in a patient with myelofibrosis secondary to polycythemia vera: a case report.
 

Author(s): Andreas Hanssønn Habberstad, Hoa Thi Tuyet Tran, Ulla Randen, Signe Spetalen, Ingunn Dybedal, Geir E Tjønnfjord, Anders Erik Astrup Dahm

Journal:

 

Polycythemia vera is a myeloproliferative disease that sometimes evolves to myelofibrosis, causing splenomegaly and neutropenia. In this case report, we describe a patient with polycythemia vera and unexplained neutropenia who later turned out to also have hairy cell leukemia.

Last Updated: 31 Dec 1969

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To view other free, full-text articles on human participants, please click on the link below.

PubMed Article Results at NCBI: 317 article(s)

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hairy Cell Leukemia" returned 22 free, full-text review articles on human participants. First 3 results:

Genomics of Hairy Cell Leukemia.
 

Author(s): Enrico Tiacci, Valentina Pettirossi, Gianluca Schiavoni, Brunangelo Falini

Journal: J. Clin. Oncol.. 2017 Mar;35(9):1002-1010.

 

Hairy cell leukemia (HCL) is a chronic mature B-cell neoplasm with unique clinicopathologic features and an initial exquisite sensitivity to chemotherapy with purine analogs; however, the disease relapses, often repeatedly. The enigmatic pathogenesis of HCL was recently clarified ...

Last Updated: 31 Dec 1969

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Consensus guidelines for the diagnosis and management of patients with classic hairy cell leukemia.
 

Author(s): Michael R Grever, Omar Abdel-Wahab, Leslie A Andritsos, Versha Banerji, Jacqueline Barrientos, James S Blachly, Timothy G Call, Daniel Catovsky, Claire Dearden, Judit Demeter, Monica Else, Francesco Forconi, Alessandro Gozzetti, Anthony D Ho, James B Johnston, Jeffrey Jones, Gunnar Juliusson, Eric Kraut, Robert J Kreitman, Loree Larratt, Francesco Lauria, Gerard Lozanski, Emili Montserrat, Sameer A Parikh, Jae H Park, Aaron Polliack, Graeme R Quest, Kanti R Rai, Farhad Ravandi, Tadeusz Robak, Alan Saven, John F Seymour, Tamar Tadmor, Martin S Tallman, Constantine Tam, Enrico Tiacci, Xavier Troussard, Clive S Zent, Thorsten Zenz, Pier Luigi Zinzani, Brunangelo Falini

Journal: Blood. 2017 02;129(5):553-560.

 

Hairy cell leukemia is an uncommon hematologic malignancy characterized by pancytopenia and marked susceptibility to infection. Tremendous progress in the management of patients with this disease has resulted in high response rates and improved survival, yet relapse and an appropriate ...

Last Updated: 31 Dec 1969

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BRAF V600E mutation in hairy cell leukemia: from bench to bedside.
 

Author(s): Brunangelo Falini, Maria Paola Martelli, Enrico Tiacci

Journal: Blood. 2016 10;128(15):1918-1927.

 

Hairy cell leukemia (HCL) is a distinct clinicopathological entity whose underlying genetic lesion has remained a mystery for over half a century. The BRAF V600E mutation is now recognized as the causal genetic event of HCL because it is somatic, present in the entire tumor clone, ...

Last Updated: 31 Dec 1969

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To view other free, full-text review articles on human participants, please click on the link below.

PubMed Review Results at NCBI: 22 review(s)

 
 
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Symptoms, Diagnosis, and Treatment

This information is provided by Genetics Home Reference.
https://ghr.nlm.nih.gov/condition/8p11-myeloproliferative-syndrome
https://ghr.nlm.nih.gov/condition/chronic-myeloid-leukemia
https://ghr.nlm.nih.gov/condition/acute-promyelocytic-leukemia
https://ghr.nlm.nih.gov/gene/HES7
https://ghr.nlm.nih.gov/condition/systemic-mastocytosis
https://ghr.nlm.nih.gov/gene/MAP2K1
https://ghr.nlm.nih.gov/condition/leydig-cell-hypoplasia
https://ghr.nlm.nih.gov/condition/langerhans-cell-histiocytosis
https://ghr.nlm.nih.gov/condition/sickle-cell-disease
https://ghr.nlm.nih.gov/primer/cell
https://ghr.nlm.nih.gov/primer/cellsdivide
https://ghr.nlm.nih.gov/condition/cytogenetically-normal-acute-myeloid-leukemia
https://ghr.nlm.nih.gov/condition/pdgfrb-associated-chronic-eosinophilic-leukemia
https://ghr.nlm.nih.gov/condition/pdgfra-associated-chronic-eosinophilic-leukemia
https://ghr.nlm.nih.gov/condition/familial-acute-myeloid-leukemia-with-mutated-cebpa
https://ghr.nlm.nih.gov/condition/core-binding-factor-acute-myeloid-leukemia
https://ghr.nlm.nih.gov/gene/CEBPA
https://ghr.nlm.nih.gov/gene/PML
https://ghr.nlm.nih.gov/gene/LIFR
https://ghr.nlm.nih.gov/gene/CLCF1
Full Results at Genetics Home Reference: 3723 matches

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Therapy Optimisation for the Treatment of Hairy Cell Leukemia
 

Status: Recruiting

Condition Summary: Hairy Cell Leukemia

 

Last Updated: 11 Jan 2018

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Cladribine With Simultaneous or Delayed Rituximab to Treat Hairy Cell Leukemia
 

Status: Recruiting

Condition Summary: Hairy Cell Leukemia

 

Last Updated: 22 Sep 2018

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Randomized Phase II Trial of Rituximab With Either Pentostatin or Bendamustine for Multiply Relapsed or Refractory Hairy Cell Leukemia
 

Status: Recruiting

Condition Summary: Hairy Cell Leukemia

 

Last Updated: 24 Oct 2018

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According to ClinicalTrials.gov there are currently 18 additional "open" studies for "Hairy Cell Leukemia" (open studies are recruiting volunteers) and 216 "Hairy Cell Leukemia" studies with "all" status. Visit ClinicalTrials.gov now to view them. Or alternatively, consider TrialsFinder for assistance:
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Relief is when you and the right researcher find each other
Finding the right clinical trial for Hairy Cell Leukemia can be challenging. However, with TrialsFinder (which uses the Reg4ALL database and privacy controls by Private Access), you can permit researchers to let you know opportunities to consider - all without revealing your identity.
Learn More