Langerhans cell histiocytosis

Common Name(s)

Langerhans cell histiocytosis, Eosinophilic Granuloma, Hand-Schuller-Christian disease

Langerhans cell histiocytosis (LCH) is a disorder that primarily affects children, but is also found in adults of all ages. People with LCH produce too many Langerhans cells or histiocytes, a form of white blood cell found in healthy people that is supposed to protect the body from infection. In people with LCH, these cells multiply excessively and build up in certain areas of the body, causing tumors called granulomas to form. The symptoms vary among affected individuals, and the cause of LCH is unknown. In most cases, this condition is not life-threatening. Some people do experience life-long problems associated with LCH.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Langerhans cell histiocytosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Langerhans cell histiocytosis" returned 345 free, full-text research articles on human participants. First 3 results:

Langerhans cell histiocytosis complicated with hemophagocytic lymphohistiocytosis in a boy with a novel XIAP mutation: A case report.
 

Author(s): Xia Guo, Qiang Li, Ju Gao

Journal: Medicine (Baltimore). 2018 Nov;97(44):e13019.

 

X-linked lymphoproliferative syndromes (XLPs) are rare, yet often fatal primary immunodeficiency diseases, which rarely manifest as Langerhans cell histiocytosis (LCH) complicated with hemophagocytic lymphohistiocytosis (HLH). Clinical data of a case of XLP-2 manifesting as LCH complicated ...

Last Updated: 31 Dec 1969

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Isolated Langerhans cell histiocytosis of the spleen: A case report.
 

Author(s): Le Hong, Gen Sun, Long Peng, Yi Tu, Yong Li, Weidong Xiao

Journal: Medicine (Baltimore). 2018 Sep;97(38):e12378.

 

Langerhans cell histiocytosis (LCH) is a relatively rare disorder characterized by the proliferation of abnormal Langerhans cells. Splenic involvement usually presents in children with multisystem LCH, and isolated LCH of the spleen is a very rare disease. Herein, we report a case ...

Last Updated: 31 Dec 1969

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Pituitary gland and bone involvement of Langerhans cell histiocytosis in a boy and brief review of the literature.
 

Author(s): Chao Miao, Lei Zhang, Ming Sun, Chao Ma

Journal: Hell J Nucl Med. ;21(2):148-150.

 

A 3 years old boy was hospitalized with a month's history of polydipsia, polyuria and low fever. There was no relevant family history. This is a rare case of Langerhans cell histiocytosis (LCH) with both bone and pituitary infiltration shown on the technetium-99m methylene diphosphonate ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Langerhans cell histiocytosis" returned 53 free, full-text review articles on human participants. First 3 results:

Successful management of multiple-systemic Langerhans cell histiocytosis involving endocrine organs in an adult: A case report and review of literature.
 

Author(s): Junhui Xie, Zhen Li, Yi Tang

Journal: Medicine (Baltimore). 2018 Jun;97(26):e11215.

 

Langerhans cell histiocytosis (LCH) involving non-endocrine organs has been frequently reported, whereas LCH involving endocrine organs is rare and the mechanism is unclear.

Last Updated: 31 Dec 1969

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Pulmonary Langerhans' cell histiocytosis in adults.
 

Author(s): Elżbieta Radzikowska

Journal: Adv Respir Med. 2017 ;85(5):277-289.

 

Pulmonary Langerhans' cell histiocytosis (PLCH) is a rare disorder of unknown cause characterised by the infiltration of the lungs and other organs by the bone marrow derived Langerhans' cells, which carry mutations of BRAF gene and/or NRAS, KRAS and MAP2K1 genes. It occurs predominantly ...

Last Updated: 31 Dec 1969

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New insights in lymphangioleiomyomatosis and pulmonary Langerhans cell histiocytosis.
 

Author(s): Olga Torre, Davide Elia, Antonella Caminati, Sergio Harari

Journal:

 

Lymphangioleiomyomatosis (LAM) and pulmonary Langerhans cell histiocytosis (PLCH) are rare diseases that lead to progressive cystic destruction of the lungs. Despite their distinctive characteristics, these diseases share several features. Patients affected by LAM or PLCH have similar ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 2 Aug 2018

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Last Updated: 2 May 2018

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Vinblastine/Prednisone Versus Single Therapy With Cytarabine for Langerhans Cell Histiocytosis (LCH)
 

Status: Recruiting

Condition Summary: Langerhans Cell Histiocytosis

 

Last Updated: 15 Nov 2017

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