Henoch-Schonlein purpura

Common Name(s)

Henoch-Schonlein purpura

Henoch-Schonlein purpura (HSP) is the most common form of blood vessel inflammation (vasculitis) in children. The disease affects the small blood vessels in the skin, joints, intestines, and kidneys. It is typically seen in children between the ages of 2 and 6 years. The cause of HSP is not known, but it is believed to be the result of an overreaction by the body’s immune system. Experts believe bacteria, viruses, medications, food, and immunizations may all be triggers for HSP. About 50% of cases occur after a child has an upper respiratory infection (cold).

The hallmark sign of HSP is a red or purple rash (purpura) that typically shows up on the legs or buttocks. The rash is the result of inflammation of the blood vessels under the skin. Other signs and symptoms of HSP may include joint pain, abdominal pain, or blood in the urine due to inflammation in the kidneys. In rare cases, serious complications can occur. These may include permanent kidney damage or folding of the intestines. Diagnosis of HSP is based on the combination of symptoms identified by the physician through a physical exam as well as a blood test to look for immune markers. A collection of affected tissue (biopsy) may be needed to confirm the diagnosis. HSP usually resolves in a few weeks with only minor treatment, including bed rest and fluids. Joint or abdominal pain can be treated with pain medications. Additional treatment options may be provided to those with serious complications of HSP. If your child has been diagnosed with HSP, talk with your doctor to discuss current treatment recommendations. Support groups are a good resource for additional information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Henoch-Schonlein purpura" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Henoch-Schonlein purpura" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Henoch-Schonlein purpura" returned 293 free, full-text research articles on human participants. First 3 results:

Chinese herbal medicine for the treatment of Henoch-Schönlein purpura nephritis in children: A prospective cohort study protocol.
 

Author(s): Jun Zhang, Jing Lv, Shuang Pang, Xiaohong Bai, Fang Yuan, Yubin Wu, Hong Jiang, Guanqi Yang, Shaoqing Zhang

Journal: Medicine (Baltimore). 2018 Jun;97(24):e11064.

 

Henoch-Schönlein purpura nephritis (HSPN) involves the renal impairment of Henoch-Schönlein purpura and can easily relapse into life-threatening late nephropathy in severe cases. Although there is a lack of validated evidence for its effectiveness, Chinese herbal medicine (CHM) ...

Last Updated: 31 Dec 1969

Go To URL
Henoch-Schönlein Purpura Complicated by Hepatocellular Carcinoma.
 

Author(s): Naoki Akizue, Eiichiro Suzuki, Masayuki Yokoyama, Masanori Inoue, Toru Wakamatsu, Tomoko Saito, Yuko Kusakabe, Sadahisa Ogasawara, Yoshihiko Ooka, Akinobu Tawada, Yugo Maru, Hiroyuki Matsue, Tetsuhiro Chiba

Journal: Intern. Med.. 2017 Nov;56(22):3041-3045.

 

Although Henoch-Schönlein purpura (HSP) is known to be accompanied by malignancies, cases with hepatobiliary cancer are extremely rare. A 62-year-old man with palpable purpura rapidly extending to both lower legs was admitted to our hospital. He was undergoing follow-up for cirrhosis ...

Last Updated: 31 Dec 1969

Go To URL
Rectal perforation in a 42-year-old woman due to Henoch-Schönlein purpura: a case report.
 

Author(s): F Almassinokiani, A Mehdizadeh Kashi, A Musavi, S Khodaverdi, K Tahermanesh, S Ariana

Journal:

 

Henoch-Schönlein purpura (HSP) is caused by deposition of IgA-containing immune complexes within the blood vessels. HSP mostly occurs in children and is less common in adults. In addition to palpable purpura, arthritis or arthralgia, renal disease and abdominal pain, gastrointestinal ...

Last Updated: 31 Dec 1969

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Henoch-Schonlein purpura" returned 35 free, full-text review articles on human participants. First 3 results:

Genetics of immunoglobulin-A vasculitis (Henoch-Schönlein purpura): An updated review.
 

Author(s): Raquel López-Mejías, Santos Castañeda, Fernanda Genre, Sara Remuzgo-Martínez, F David Carmona, Javier Llorca, Ricardo Blanco, Javier Martín, Miguel A González-Gay

Journal: Autoimmun Rev. 2018 Mar;17(3):301-315.

 

Immunoglobulin-A vasculitis (IgAV) is classically a childhood small-sized blood vessel vasculitis with predominant involvement of the skin. Gastrointestinal and joint manifestations are common in patients diagnosed with this condition. Nephritis, which is more severe in adults, constitutes ...

Last Updated: 31 Dec 1969

Go To URL
New insights in the pathogenesis of immunoglobulin A vasculitis (Henoch-Schönlein purpura).
 

Author(s): Marieke H Heineke, Aranka V Ballering, Agnès Jamin, Sanae Ben Mkaddem, Renato C Monteiro, Marjolein Van Egmond

Journal: Autoimmun Rev. 2017 Dec;16(12):1246-1253.

 

Immunoglobulin A vasculitis (IgAV), also referred to as Henoch-Schönlein purpura, is the most common form of childhood vasculitis. The pathogenesis of IgAV is still largely unknown. The disease is characterized by IgA1-immune deposits, complement factors and neutrophil infiltration, ...

Last Updated: 31 Dec 1969

Go To URL
Henoch-Schönlein Purpura: A Literature Review.
 

Author(s): Liv Eline Hetland, Kjærsti Sørensen Susrud, Kim Hein Lindahl, Anette Bygum

Journal: Acta Derm. Venereol.. 2017 Nov;97(10):1160-1166.

 

Henoch-Schönlein purpura is the most common childhood vasculitis, but may also affect adults. This article reviews the literature since 2011 on advances in diagnosis, clinical disease manifestations, pathophysiology and treatment of Henoch-Schönlein purpura. The clinical manifestations ...

Last Updated: 31 Dec 1969

Go To URL
 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of the Role of Regulator T Cells in the Pathophysiology of Childhood Henoch Schönlein Purpura
 

Status: Recruiting

Condition Summary: Henoch Schönlein Purpura

 

Last Updated: 18 Apr 2018

Go to URL
The Research of Standard Diagnosis and Treatment for Severe HSP in Children
 

Status: Recruiting

Condition Summary: Henoch-Schoenlein Purpura

 

Last Updated: 2 Apr 2018

Go to URL
The Research of Standard Diagnosis and Treatment for HSPN in Children
 

Status: Recruiting

Condition Summary: Henoch-Schoenlein Purpura Nephritis

 

Last Updated: 2 Apr 2018

Go to URL