Hereditary diffuse gastric cancer

Common Name(s)

Hereditary diffuse gastric cancer, HDGC

Hereditary diffuse gastric cancer (HDGC) is a type of stomach (gastric) cancer that runs through families. HDGC is different from other types of stomach cancer because the cancer cells do not form into a solid tumor. Instead, HDGC cancer cells disperse or scatter throughout the stomach tissue. Because of this, this type of cancer spreads (metastasizes) more easily to other parts of the body.

Symptoms of this condition are often not recognized until the cancer is in later stages. These symptoms may include stomach pain, vomiting, and weight loss. Unfortunately, this type of cancer is difficult to catch in early stages. Therefore, if you have a history of HDGC in your family, it is important to get regular and frequent stomach (endoscopy) exams to detect for any cancer cell formation.

HDGC is caused by a genetic mutation in the CDH1 gene which is located on chromosome 16. When a mutation is present in the gene, the gene is unable to pass along the correct instructions to the rest of the cells of the body. As a result, a person with a mutation in the CDH1 gene has a higher risk of developing HDGC, lobular breast cancer, and some forms of colon cancer.

Inheriting a CDH1 mutation does not mean that you will definitely develop these forms of cancer. Rather, the mutation increases your risk of developing HDGC, lobular breast cancer and colon cancer. If you have a family member diagnosed with HDGC or a mutation in the CDH1 gene, talk with a genetic counselor to see if genetic testing is right for you. If you or a family member has been diagnosed with HDGC, talk with your doctor and specialists about the most current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hereditary diffuse gastric cancer" for support, advocacy or research.

No Stomach For Cancer

Our mission is to support research and united the caring power of people worldwide affected by stomach cancer. We advance awareness and education about stomach cancer, including Hereditary Diffuse Gastric Cancer (HDGC), provide a support network for affected families, and support research for screening, early detection, treatment, and prevention of stomach cancer.

Last Updated: 7 Jan 2016

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hereditary diffuse gastric cancer" for support, advocacy or research.

No Stomach For Cancer

Our mission is to support research and united the caring power of people worldwide affected by stomach cancer. We advance awareness and education about stomach cancer, including Hereditary Diffuse Gastric Cancer (HDGC), provide a support network for affected families, and support research for screening, early detection, treatment, and prevention of stomach cancer.

http://www.nostomachforcancer.org

Last Updated: 7 Jan 2016

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hereditary diffuse gastric cancer" returned 29 free, full-text research articles on human participants. First 3 results:

Comparative study of endoscopic surveillance in hereditary diffuse gastric cancer according to CDH1 mutation status.
 

Author(s): Emma Z Mi, Ella Z Mi, Massimiliano di Pietro, Maria O'Donovan, Richard H Hardwick, Susan Richardson, Hisham Ziauddeen, Paul C Fletcher, Carlos Caldas, Marc Tischkowitz, Krish Ragunath, Rebecca C Fitzgerald

Journal: Gastrointest. Endosc.. 2018 02;87(2):408-418.

 

Hereditary diffuse gastric cancer (HDGC) accounts for 1% of gastric cancer cases. For patients with a germline CDH1 mutation, risk-reducing gastrectomy is recommended. However, for those delaying surgery or for families with no causative mutation identified, regular endoscopy is advised. ...

Last Updated: 31 Dec 1969

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Transcriptomic profiling and quantitative high-throughput (qHTS) drug screening of CDH1 deficient hereditary diffuse gastric cancer (HDGC) cells identify treatment leads for familial gastric cancer.
 

Author(s): Ina Chen, Lesley Mathews-Greiner, Dandan Li, Abisola Abisoye-Ogunniyan, Satyajit Ray, Yansong Bian, Vivek Shukla, Xiaohu Zhang, Raj Guha, Craig Thomas, Berkley Gryder, Athina Zacharia, Joal D Beane, Sarangan Ravichandran, Marc Ferrer, Udo Rudloff

Journal:

 

Patients with hereditary diffuse gastric cancer (HDGC), a cancer predisposition syndrome associated with germline mutations of the CDH1 (E-cadherin) gene, have few effective treatment options. Despite marked differences in natural history, histopathology, and genetic profile to patients ...

Last Updated: 31 Dec 1969

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An investigation of the factors effecting high-risk individuals' decision-making about prophylactic total gastrectomy and surveillance for hereditary diffuse gastric cancer (HDGC).
 

Author(s): Nina Hallowell, Shirlene Badger, Sue Richardson, Carlos Caldas, Richard H Hardwick, Rebecca C Fitzgerald, Julia Lawton

Journal: Fam. Cancer. 2016 10;15(4):665-76.

 

Hereditary diffuse gastric cancer has an early onset and poor prognosis, therefore, individuals who carry a pathogenic (CDH1) mutation in the E-cadherin gene (CDH1) are offered endoscopic surveillance and advised to undergo prophylactic total gastrectomy (PTG) in their early to mid-twenties. ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hereditary diffuse gastric cancer" returned 7 free, full-text review articles on human participants. First 3 results:

Predicting the Functional Impact of CDH1 Missense Mutations in Hereditary Diffuse Gastric Cancer.
 

Author(s): Soraia Melo, Joana Figueiredo, Maria Sofia Fernandes, Margarida Gonçalves, Eurico Morais-de-Sá, João Miguel Sanches, Raquel Seruca

Journal:

 

The role of E-cadherin in Hereditary Diffuse Gastric Cancer (HDGC) is unequivocal. Germline alterations in its encoding gene () are causative of HDGC and occur in about 40% of patients. Importantly, while in most cases alterations result in the complete loss of E-cadherin associated ...

Last Updated: 31 Dec 1969

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Hereditary diffuse gastric cancer: updated clinical guidelines with an emphasis on germline CDH1 mutation carriers.
 

Author(s): Rachel S van der Post, Ingrid P Vogelaar, Fátima Carneiro, Parry Guilford, David Huntsman, Nicoline Hoogerbrugge, Carlos Caldas, Karen E Chelcun Schreiber, Richard H Hardwick, Margreet G E M Ausems, Linda Bardram, Patrick R Benusiglio, Tanya M Bisseling, Vanessa Blair, Eveline Bleiker, Alex Boussioutas, Annemieke Cats, Daniel Coit, Lynn DeGregorio, Joana Figueiredo, James M Ford, Esther Heijkoop, Rosella Hermens, Bostjan Humar, Pardeep Kaurah, Gisella Keller, Jennifer Lai, Marjolijn J L Ligtenberg, Maria O'Donovan, Carla Oliveira, Hugo Pinheiro, Krish Ragunath, Esther Rasenberg, Susan Richardson, Franco Roviello, Hans Schackert, Raquel Seruca, Amy Taylor, Anouk Ter Huurne, Marc Tischkowitz, Sheena Tjon A Joe, Benjamin van Dijck, Nicole C T van Grieken, Richard van Hillegersberg, Johanna W van Sandick, Rianne Vehof, J Han van Krieken, Rebecca C Fitzgerald

Journal: J. Med. Genet.. 2015 Jun;52(6):361-74.

 

Germline CDH1 mutations confer a high lifetime risk of developing diffuse gastric (DGC) and lobular breast cancer (LBC). A multidisciplinary workshop was organised to discuss genetic testing, surgery, surveillance strategies, pathology reporting and the patient's perspective on multiple ...

Last Updated: 31 Dec 1969

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Hereditary diffuse gastric cancer: a family diagnosis and treatment.
 

Author(s): Adedayo A Onitilo, Govinda Aryal, Jessica M Engel

Journal: Clin Med Res. 2013 Feb;11(1):36-41.

 

Hereditary diffuse gastric cancer (HDGC) is a rare cancer representing approximately 2% of all gastric cancers. It is caused by CDHI gene mutations, inherited in an autosomal dominant fashion, that affect the function of E-cadherin. Approximately 38% of HDGC families have a CDHI gene ...

Last Updated: 31 Dec 1969

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Last Updated: 20 Sep 2018

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