Charcot-Marie-Tooth Disease
Common Name(s)
Charcot-Marie-Tooth Disease, Hereditary motor and sensory neuropathy
Advocacy and Support Organizations
Condition Specific Organizations
Following organizations serve the condition "Charcot-Marie-Tooth Disease" for support, advocacy or research.
Our mission is to ensure that everyone in the world with a rare disease has a safe place to go and connect with others like them.
Our mission ... to support the development of new drugs to treat CMT, to improve the quality of life for people with CMT, and, ultimately, to find a cure. Our vision ... a world without CMT.
CMT United Kingdom is working to support those affected by Charcot-Marie-Tooth Disease, also known as Hereditary Motor and Sensory Neuropathy.
HNF's mission is to find treatments that will halt, reverse and ultimately cure Charcot-Marie-Tooth. Our Therapeutic Research In Accelerated Discovery (TRIAD) is a collaborative effort involving academia, government, and industry, to develop treatments for CMT. Currently TRIAD is a consortia that spans the drug discovery, drug development, and diagnostic continuum.
MDA is the nonprofit health agency dedicated to curing muscular dystrophy, ALS and related diseases by funding worldwide research. The Association also provides comprehensive health care and support services, advocacy and education.
There are over 40 different types of Muscular Dystrophy and related Neuromuscular conditions.These conditions are characterised by loss of muscular strength,as progressive muscle wasting or nerve
How do you compare to others with this condition?
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Advocacy and Support Organizations
Condition Specific Organizations
Following organizations serve the condition "Charcot-Marie-Tooth Disease" for support, advocacy or research.
Our mission is to ensure that everyone in the world with a rare disease has a safe place to go and connect with others like them.
http://www.bensfriends.org Our mission ... to support the development of new drugs to treat CMT, to improve the quality of life for people with CMT, and, ultimately, to find a cure. Our vision ... a world without CMT.
http://www.cmtausa.org CMT United Kingdom is working to support those affected by Charcot-Marie-Tooth Disease, also known as Hereditary Motor and Sensory Neuropathy.
http://www.cmt.org.uk HNF's mission is to find treatments that will halt, reverse and ultimately cure Charcot-Marie-Tooth. Our Therapeutic Research In Accelerated Discovery (TRIAD) is a collaborative effort involving academia, government, and industry, to develop treatments for CMT. Currently TRIAD is a consortia that spans the drug discovery, drug development, and diagnostic continuum.
http://www.hnf-cure.org MDA is the nonprofit health agency dedicated to curing muscular dystrophy, ALS and related diseases by funding worldwide research. The Association also provides comprehensive health care and support services, advocacy and education.
http://www.mdausa.org There are over 40 different types of Muscular Dystrophy and related Neuromuscular conditions.These conditions are characterised by loss of muscular strength,as progressive muscle wasting or nerve
http://www.mdachina.orgRecommended Apps
Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.
Finding the right clinical trial for Charcot-Marie-Tooth Disease can be challenging. However, with TrialsFinder (which uses the Reg4ALL database and privacy controls by Private Access), you can permit researchers to let you know opportunities to consider - all without revealing your identity.
General Resources
We hope this will give you the insight that you are not alone. Our goal was to delve deeper into the world of CMT and to paint a vivid picture of some of the emotional, spiritual and psychological challenges that accompany living with CMT.
Scientific Literature
Articles from the PubMed Database
Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Charcot-Marie-Tooth Disease" returned 293 free, full-text research articles on human participants.
First 3 results:
Journal: Science. 2018 04;360(6386):336-341.
Mitofusins (MFNs) promote fusion-mediated mitochondrial content exchange and subcellular trafficking. Mutations in cause neurodegenerative Charcot-Marie-Tooth disease type 2A (CMT2A). We showed that MFN2 activity can be determined by Met and His interactions with Asp and Leu and ...
Journal: Medicine (Baltimore). 2017 Dec;96(49):e9176.
Charcot-Marie-Tooth disease (CMT) is typically an autosomal dominant, inherited neuropathy, although there is a rare male X-linked CMT. Such patients show central nervous system (CNS) involvement in addition to peripheral neuropathy. Recently, we encountered a patient who presented ...
Journal:
Charcot-Marie-Tooth disease (CMT) is the most common inherited disorder of the peripheral nervous system, yet no studies have compared the mortality in patients with CMT with that of the general population, and prevalence estimates vary considerably. We performed a nationwide register-based ...
To view other free, full-text articles on human participants, please click on the link below.
Reviews from the PubMed Database
Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Charcot-Marie-Tooth Disease" returned 24 free, full-text review articles on human participants.
First 3 results:
Journal: Neuromuscul. Disord.. 2017 May;27(5):487-491.
Charcot-Marie-Tooth type 4B1 (CMT4B1) is an autosomal recessive motor and sensory demyelinating neuropathy characterized by the association of early-onset neurological symptoms and typical histological findings. The natural history and the clinical variability of the disease are still ...
Journal: J. Neurosci.. 2016 08;36(31):8067-9.
Journal: Neuroepidemiology. 2016 ;46(3):157-65.
Charcot-Marie-Tooth disease (CMT) is the most common inherited neuropathy. CMT is classified into 2 main subgroups: CMT type 1 (CMT1; demyelinating form) and CMT type 2 (CMT2; axonal form). The objectives of this study were to systematically review and assess the quality of studies ...
To view other free, full-text review articles on human participants, please click on the link below.
Symptoms, Diagnosis, and Treatment
https://ghr.nlm.nih.gov/gene/MPZ
https://ghr.nlm.nih.gov/gene/SH3TC2
https://ghr.nlm.nih.gov/gene/HSPB1
https://ghr.nlm.nih.gov/gene/HSPB8
https://ghr.nlm.nih.gov/gene/MFN2
https://ghr.nlm.nih.gov/gene/GARS
https://ghr.nlm.nih.gov/gene/NEFL
https://ghr.nlm.nih.gov/gene/FIG4
https://ghr.nlm.nih.gov/gene/RAB7A
https://ghr.nlm.nih.gov/gene/MTMR2
https://ghr.nlm.nih.gov/gene/EGR2
https://ghr.nlm.nih.gov/gene/DNM2
https://ghr.nlm.nih.gov/gene/PMP22
https://ghr.nlm.nih.gov/gene/MED25
https://ghr.nlm.nih.gov/gene/DHTKD1
https://ghr.nlm.nih.gov/gene/LRSAM1
https://ghr.nlm.nih.gov/gene/FGD4
https://ghr.nlm.nih.gov/gene/PRX
https://ghr.nlm.nih.gov/gene/GDAP1
There are currently no related results available in GeneReviews.
Clinical Trial Information This information is provided by ClinicalTrials.gov
Condition Summary: Charcot-Marie-Tooth Disease
Condition Summary: Charcot-Marie-Tooth Disease
Condition Summary: Charcot-Marie-Tooth Disease, Type IA
Finding the right clinical trial for Charcot-Marie-Tooth Disease can be challenging. However, with TrialsFinder (which uses the Reg4ALL database and privacy controls by Private Access), you can permit researchers to let you know opportunities to consider - all without revealing your identity.