Hereditary spastic paraplegia

Common Name(s)

Hereditary spastic paraplegia, Hereditary Spastic Paraparesis, Familial Spastic Paraparesis

Hereditary spastic paraplegia is a group of hereditary, degenerative, neurological disorders that primarily affect the upper motor neurons. Upper motor neurons in the brain and spinal cord deliver signals to the lower motor neurons which in turn, carry messages to the muscles. In hereditary spastic paraplegia, upper motor neurons slowly degenerate so the muscles do not receive the correct messages causing progressive spasticity (increased muscle tone/stiffness) and weakness of the legs leading to difficulty walking.  As degeneration continues, symptoms worsen.  
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hereditary spastic paraplegia" for support, advocacy or research.

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Spastic Paraplegia Foundation, Inc.

We are committed to discovering the cures for HSP and PLS by promoting research, providing accurate information about these disorders, and creating opportunities for mutual support and sharing.

Last Updated: 29 Oct 2012

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hereditary spastic paraplegia" for support, advocacy or research.

Logo
Spastic Paraplegia Foundation, Inc.

We are committed to discovering the cures for HSP and PLS by promoting research, providing accurate information about these disorders, and creating opportunities for mutual support and sharing.

http://www.sp-foundation.org

Last Updated: 29 Oct 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hereditary spastic paraplegia" returned 152 free, full-text research articles on human participants. First 3 results:

Botulinum toxin for hereditary spastic paraplegia: effects on motor and non-motor manifestations.
 

Author(s): Katiane R Servelhere, Ingrid Faber, Alberto Martinez, Renato Nickel, Adriana Moro, Francisco M B Germiniani, Mariana Moscovich, Tatiane R Blume, Renato P Munhoz, Hélio A G Teive, Marcondes C França

Journal: Arq Neuropsiquiatr. 2018 Mar;76(3):183-188.

 

Motor and non-motor manifestations are common and disabling features of hereditary spastic paraplegia (HSP). Botulinum toxin type A (Btx-A) is considered effective for spasticity and may improve gait in these patients. Little is known about the effects of Btx-A on non-motor symptoms ...

Last Updated: 31 Dec 1969

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Gait phenotypes in paediatric hereditary spastic paraplegia revealed by dynamic time warping analysis and random forests.
 

Author(s): Irene Pulido-Valdeolivas, David Gómez-Andrés, Juan Andrés Martín-Gonzalo, Irene Rodríguez-Andonaegui, Javier López-López, Samuel Ignacio Pascual-Pascual, Estrella Rausell

Journal:

 

The Hereditary Spastic Paraplegias (HSP) are a group of heterogeneous disorders with a wide spectrum of underlying neural pathology, and hence HSP patients express a variety of gait abnormalities. Classification of these phenotypes may help in monitoring disease progression and personalizing ...

Last Updated: 31 Dec 1969

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Genotype-phenotype correlations and expansion of the molecular spectrum of AP4M1-related hereditary spastic paraplegia.
 

Author(s): Conceição Bettencourt, Vincenzo Salpietro, Stephanie Efthymiou, Viorica Chelban, Deborah Hughes, Alan M Pittman, Monica Federoff, Thomas Bourinaris, Martha Spilioti, Georgia Deretzi, Triantafyllia Kalantzakou, Henry Houlden, Andrew B Singleton, Georgia Xiromerisiou

Journal:

 

Autosomal recessive hereditary spastic paraplegia (HSP) due to AP4M1 mutations is a very rare neurodevelopmental disorder reported for only a few patients.

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hereditary spastic paraplegia" returned 18 free, full-text review articles on human participants. First 3 results:

Hereditary spastic paraplegia from 1880 to 2017: an historical review.
 

Author(s): Ingrid Faber, Eduardo Rafael Pereira, Alberto R M Martinez, Marcondes França, Hélio Afonso Ghizoni Teive

Journal: Arq Neuropsiquiatr. 2017 Nov;75(11):813-818.

 

The authors have constructed a brief timeline of major clinical research related to hereditary spastic paraplegia (HSP). This timeline summarizes the evolution of HSP research, from the first clinical descriptions by Adolf von Strümpell in 1880 to the present day, with the transformation ...

Last Updated: 31 Dec 1969

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Pathophysiology, diagnostic work-up and management of balance impairments and falls in patients with hereditary spastic paraplegia.
 

Author(s): Jorik Nonnekes, Bas van Lith, Bart P van de Warrenburg, Vivian Weerdesteyn, Alexander C H Geurts

Journal: J Rehabil Med. 2017 May;49(5):369-377.

 

Balance impairments are common in patients with hereditary spastic paraplegia and are among the most debilitating symptoms, as they frequently result in falls and fall-related injuries. Several features of hereditary spastic paraplegia contribute to balance impairments and multiple ...

Last Updated: 31 Dec 1969

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Sequential bilateral complete rupture of the rectus femoris muscle in a patient with hereditary spastic paraplegia.
 

Author(s): Lize Raes, Nathalie Draulans, Anja van Campenhout, Els Ortibus, Koen Peers, Carlotte Kiekens

Journal: Eur J Phys Rehabil Med. 2017 Oct;53(5):794-797.

 

This case raises questions about the pathophysiology of muscle ruptures in highly functional patients with hereditary spastic paraplegia (HSP) who have only minor spasticity and no significant muscle shortening. Literature on the skeletal muscle changes secondary to spasticity or ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Disease Natural History and Biomarkers of SPG3A, SPG4A, and SPG31
 

Status: Recruiting

Condition Summary: Hereditary Spastic Paraplegia

 

Last Updated: 12 Sep 2018

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The Pre-SPG4 Study
 

Status: Recruiting

Condition Summary: Hereditary Spastic Paraplegia; Hereditary, Spastic Paraplegia, Autosomal Dominant

 

Last Updated: 2 Jul 2017

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Studying Non-motor Symptoms in SPG4
 

Status: Recruiting

Condition Summary: SPG4

 

Last Updated: 1 May 2018

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