Gilbert syndrome

Common Name(s)

Gilbert syndrome, Hyperbilirubinemia type 1

Gilbert syndrome is an inherited condition in which the liver does not correctly process bilirubin, a yellow-ish substance produced during the normal breakdown of old red blood cells. Bilirubin travels through the bloodstream to the liver where it is processed and removed from the blood. The symptom of cholemia or hyperbilirubinemia (high bilirubin levels) is jaundice or yellowing of the skin and whites of the eyes. It is generally a mild condition and does not usually require treatment. Times of jaundice are sometimes induced in children and adults during infections and illness, lack of sleep, fasting (stretches of not eating), menstruation cycles, and stress and may be accompanied by mild abdominal pain or nausea. The jaundice during these times goes away on its own after the person recovers. In the newborn period, jaundice can be longer-lasting and more severe. Diagnosis often occurs by accident when blood is drawn for another reason unless a person or newborn has a severe bout of jaundice and the yellow in the skin or eyes is noted. Treatment is only necessary if bilirubin levels are very high.

More males than females have been diagnosed with Gilbert syndrome. This condition is caused by mutations in the UGT1A1 gene. Gilbert syndrome is inherited or passed through families in an autosomal recessive manner. This means that to be affected, an individual must have two copies of the changed gene that causes the condition. An affected person has then inherited one changed gene from each of his or her parents. Each child of two carrier parents has a 25% chance of inheriting both changed genes and therefore the condition. A genetic counselor can provide an understanding of the underlying cause as well as recurrence risks.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Gilbert syndrome" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Gilbert syndrome" returned 34 free, full-text research articles on human participants. First 3 results:

Gilbert syndrome combined with prolonged jaundice caused by contrast agent: Case report.
 

Author(s): Jian-Dan Qian, Feng-Qin Hou, Tai-Ling Wang, Chen Shao, Gui-Qiang Wang

Journal: World J. Gastroenterol.. 2018 Apr;24(13):1486-1490.

 

This case highlights a patient with Gilbert syndrome who underwent endoscopic retrograde cholangiopancreatography (ERCP) with removal of bile duct stones, who then experienced an unexplained increase in bilirubin, with total bilirubin (TBIL) levels increasing from 159.5 ╬╝mol/L to ...

Last Updated: 31 Dec 1969

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Differences in UGT1A1 gene mutations and pathological liver changes between Chinese patients with Gilbert syndrome and Crigler-Najjar syndrome type II.
 

Author(s): Lei Sun, Man Li, Liang Zhang, Xiaoying Teng, Xiangmei Chen, Xingang Zhou, Zhiyuan Ma, Liming Qi, Peng Wang

Journal: Medicine (Baltimore). 2017 Nov;96(45):e8620.

 

Diagnosis of Crigler-Najjar syndrome type II (CNS-II) and Gilbert syndrome (GS) based on the serum bilirubin concentration is difficult, because this parameter can fluctuate under certain conditions. The aim of this study was to explore differences in UGT1A1 gene mutations, which ...

Last Updated: 31 Dec 1969

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Mixed Dubin-Gilbert Syndrome: A Compound Heterozygous Phenotype of Two Novel Variants in Gene.
 

Author(s): Jun Jiang, Hua-Gui Wang, Wei-Li Wu, Xiang-Xin Peng

Journal: Chin. Med. J.. 2017 Apr;130(8):1003-1005.

 

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Gilbert syndrome" returned 0 free, full-text review articles on human participants.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Biomarker for Patients With Gilbert Disease
 

Status: Recruiting

Condition Summary: Gilbert Syndrome; Gilbert-Lereboullet Syndrome; Meulengracht Syndrome

 

Last Updated: 11 Oct 2017

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