Hyperemesis gravidarum

Common Name(s)

Hyperemesis gravidarum

Hyperemesis gravidarum is severe nausea and vomiting that starts during the first trimester or first 12 weeks of pregnancy. Symptoms usually begin 4 to 6 weeks into the pregnancy. Symptoms may lessen by 15 to 20 weeks, although for some women the symptoms may last the entire pregnancy. Risk factors for this condition are a diet high in saturated fat, epilepsy, untreated asthma, kidney or liver disease, and a history of hyperemesis gravidarum in your family. Hyperemesis gravidarum is more common in the first pregnancy and when carrying more than one baby at a time.

In addition to nausea and vomiting, hyperemesis gravidarum may cause dehydration, significant weight loss, nutritional deficiencies, electrolyte imbalance, anemia, fatigue, and headaches. If you or someone you know is experiencing severe nausea and vomiting and may be pregnant, it is important to talk to your doctor or obstetrician. Early treatment is important because dehydration and weight loss during pregnancy are dangerous for both you and your baby.

Testing for this condition may include a blood draw to check blood count and electrolyte levels, urine sample, physical examination, and ultrasound imaging. Treatment usually includes rest, fluids, and nutritional supplements as well as emotional support. If you have been diagnosed with hyperemesis gravidarum, talk to your doctor or obstetrician about the most current treatment options. Support groups are also available for more resources and information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hyperemesis gravidarum" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hyperemesis gravidarum" returned 90 free, full-text research articles on human participants. First 3 results:

Hospital admission for hyperemesis gravidarum in women at increased risk of spontaneous preterm birth.
 

Author(s): Ira Kleine, Ana Da Silva, Wafaa Ahmed, Frida Forya, Sara M Whitten, Anna L David, Catherine P James

Journal: Birth. 2017 12;44(4):384-389.

 

Progesterone administration prevents spontaneous preterm birth (sPTB) in women at increased risk. Progesterone concentration is lower in women with subsequent sPTB. Conversely, high concentrations of progesterone are implicated in the pathogenesis of hyperemesis gravidarum (HG). We ...

Last Updated: 31 Dec 1969

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Hyperemesis gravidarum and the risk of emotional distress during and after pregnancy.
 

Author(s): Helena Kames Kjeldgaard, Malin Eberhard-Gran, Jūratė Šaltytė Benth, Åse Vigdis Vikanes

Journal: Arch Womens Ment Health. 2017 12;20(6):747-756.

 

Hyperemesis gravidarum (HG) is a pregnancy condition characterised by severe nausea and vomiting. Previous studies have shown an association between HG and depressive symptoms during pregnancy, but little is known about the risk of maternal psychological distress following an HG pregnancy. ...

Last Updated: 31 Dec 1969

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Evaluation of the hematologic system as a marker of subclinical inflammation in hyperemesis gravidarum: a case control study.
 

Author(s): Fatma Beyazit, Filiz Halici Öztürk, Eren Pek, Mesut Abdülkerim Ünsal

Journal: Ginekol. Pol.. 2017 ;88(6):315-319.

 

Current evidence suggests that subclinical inflammation plays a significant role in the development of hyperemesis gravidarum (HEG). Simple hematological markers, such as mean platelet volume (MPV), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR), have ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hyperemesis gravidarum" returned 12 free, full-text review articles on human participants. First 3 results:

Hyperemesis Gravidarum: A Review of Recent Literature.
 

Author(s): Viktoriya London, Stephanie Grube, David M Sherer, Ovadia Abulafia

Journal: Pharmacology. 2017 ;100(3-4):161-171.

 

In the United States, hyperemesis gravidarum is the most common cause of hospitalization during the first half of pregnancy and is second only to preterm labor for hospitalizations in pregnancy overall. In approximately 0.3-3% of pregnancies, hyperemesis gravidarum is prevalent and ...

Last Updated: 31 Dec 1969

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Hyperemesis Gravidarum is associated with substantial economic burden in addition to severe physical and psychological suffering.
 

Author(s): Jone Trovik, Åse Vikanes

Journal:

 

Hyperemesis gravidarum (HG) affects 1 % of all pregnant women and in western societies it is the most common cause for hospital admission during first trimester. The economic burden of the disease has barely been studied. To estimate the Israeli national burden of HG, Konikoff and ...

Last Updated: 31 Dec 1969

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Treatments for hyperemesis gravidarum and nausea and vomiting in pregnancy: a systematic review and economic assessment.
 

Author(s): Amy O'Donnell, Catherine McParlin, Stephen C Robson, Fiona Beyer, Eoin Moloney, Andrew Bryant, Jennifer Bradley, Colin Muirhead, Catherine Nelson-Piercy, Dorothy Newbury-Birch, Justine Norman, Emma Simpson, Brian Swallow, Laura Yates, Luke Vale

Journal: Health Technol Assess. 2016 10;20(74):1-268.

 

Nausea and vomiting in pregnancy (NVP) affects up to 85% of all women during pregnancy, but for the majority self-management suffices. For the remainder, symptoms are more severe and the most severe form of NVP - hyperemesis gravidarum (HG) - affects 0.3-1.0% of pregnant women. There ...

Last Updated: 31 Dec 1969

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Endothelial Dysfunction in Hyperemesis Gravidarum
 

Status: Recruiting

Condition Summary: Hyperemesis; Gravidarum, With Dehydration

 

Last Updated: 8 Dec 2016

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Haloperidol Versus Ondansetron for Cannabis Hyperemesis Syndrome (HaVOC)
 

Status: Recruiting

Condition Summary: Cannabis Use Disorder

 

Last Updated: 15 Jun 2018

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