Hypotrichosis 3

Common Name(s)

Hypotrichosis 3

Hypotrichosis simplex can affect all body hair (generalized; see {605389}) or be limited to the scalp. Usually patients with the scalp-limited form of hypotrichosis present with normal hair at birth; they experience a progressive, gradual loss of scalp hair beginning at the middle of the first decade and leading to almost complete loss of scalp hair by the third decade. A few sparse, fine, short hairs remain in some individuals. Body hair, beard, eyebrows, axillary hair, teeth, and nails develop normally. Light and electron microscopy of hairs from patients with early hypotrichosis simplex revealed no structural changes, whereas hairs from patients with advanced hypotrichosis showed focal areas of defective cuticular structure. Men and women are equally affected (summary by {1:Betz et al., 2000}). For a discussion of genetic heterogeneity of nonsyndromic hypotrichosis, see HYPT1 ({605389}).
 

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Condition Specific Organizations

Following organizations serve the condition "Hypotrichosis 3" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hypotrichosis 3" returned 4 free, full-text research articles on human participants. First 3 results:

A homozygous nonsense mutation in the human desmocollin-3 (DSC3) gene underlies hereditary hypotrichosis and recurrent skin vesicles.
 

Author(s): Muhammad Ayub, Sulman Basit, Musharraf Jelani, Fazal Ur Rehman, Muhammad Iqbal, Masoom Yasinzai, Wasim Ahmad

Journal: Am. J. Hum. Genet.. 2009 Oct;85(4):515-20.

 

Desmosomes are the major players in epidermis and cardiac muscles and contribute to intercellular binding and maintenance of tissue integrity. Two important constituents of desmosomes are transmembrane cadherins named desmogleins and desmocollins. The critical role of these desmosomal ...

Last Updated: 31 Dec 1969

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Identification of a novel locus for Marie Unna hereditary hypotrichosis to a 17.5 cM interval at 1p21.1-1q21.3.
 

Author(s): Sen Yang, Min Gao, Yong Cui, Kai-Lin Yan, Yun-Qing Ren, Guo-Long Zhang, Pei-Guang Wang, Feng-Li Xiao, Wen-Hui Du, Yan-Hua Liang, Liang-Dan Sun, Shi-Jie Xu, Wei Huang, Xue-Jun Zhang

Journal: J. Invest. Dermatol.. 2005 Oct;125(4):711-4.

 

Marie Unna hereditary hypotrichosis (MUHH) is a rare autosomal dominant disorder characterized by coarse, wiry, twisted hair developed in early childhood and followed by the development of alopecia. A locus for this disorder was localized to chromosome 8p, but no gene responsible ...

Last Updated: 31 Dec 1969

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A novel locus for autosomal recessive form of hypotrichosis maps to chromosome 3q26.33-q27.3.
 

Author(s): M Aslam, M H Chahrour, A Razzaq, S Haque, K Yan, S M Leal, W Ahmad

Journal: J. Med. Genet.. 2004 Nov;41(11):849-52.

 

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

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The terms "Hypotrichosis 3" returned 0 free, full-text review articles on human participants.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

A Study of ATI-50002 Topical Solution for the Treatment of Alopecia Areata
 

Status: Recruiting

Condition Summary: Alopecia Areata

 

Last Updated: 17 May 2018

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A Study of Baricitinib (LY3009104) in Participants With Severe or Very Severe Alopecia Areata
 

Status: Not yet recruiting

Condition Summary: Alopecia Areata

 

Last Updated: 18 Jun 2018

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Intralesional Steroids in the Treatment of Alopecia Areata
 

Status: Recruiting

Condition Summary: Alopecia Areata

 

Last Updated: 28 Jul 2017

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