Invasive lobular carcinoma

Common Name(s)

Invasive lobular carcinoma, Invasive lobular carcinoma, breast cancer

Invasive lobular carcinoma (ILC) is a type of breast cancer that originates in the milk producing tissues (lobules) of the breast and spreads to other tissue. Cancers form when a mutation in DNA causes certain cells to grow out of control, sometimes forming a lump or a tumor. Some of these cancerous cells can break off and spread to other parts of the body where they will continue to grow. This process is known as metastasis. Many of the risk factors for breast cancer are related to estrogen exposure, such as older age, having children later in life, having few or no children, taking estrogen-containing medications, early menarche (first period), and late menopause. Other risk factors include older age, obesity, and family and individual history of certain types of cancer.

Signs of ILC include swelling or hardened areas of the breast, nipple or breast pain, nipple discharge, and skin irritation (redness, thickening, scaling), and skin puckering. Unlike invasive ductal carcinoma, ILC will almost never present with a lump or mass in the breast. Instead, ILC is often diagnosed by mammogram or imaging of the breast. Diagnosis is then confirmed by taking a biopsy, or sample, of the affected tissue. In one third of affected individuals, ILC is found bilaterally, or in both breasts.

Treatment options for ILC depend on the stage of disease. The stage of cancer will be determined based on the tumor size and whether it has spread to nearby lymph nodes or to other organs by metastasis. Treatment options may include surgery for tumor removal, radiation therapy, chemotherapy, hormone therapy, and other methods. If you have been diagnosed with invasive lobular carcinoma, talk to your doctor about the best treatment options. In addition, a genetic counselor can help discuss inheritance and risks to other family members. Support groups are a good source of information and can help connect you with others in the breast cancer community.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Invasive lobular carcinoma" for support, advocacy or research.

Logo
Bay Area Cancer Connections

We support people touched by breast and ovarian cancer by providing comprehensive, personalized services in an atmosphere of warmth and compassion.

Last Updated: 21 May 2015

View Details
No Stomach For Cancer

Our mission is to support research and united the caring power of people worldwide affected by stomach cancer. We advance awareness and education about stomach cancer, including Hereditary Diffuse Gastric Cancer (HDGC), provide a support network for affected families, and support research for screening, early detection, treatment, and prevention of stomach cancer.

Last Updated: 7 Jan 2016

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Invasive lobular carcinoma" for support, advocacy or research.

Logo
Bay Area Cancer Connections

We support people touched by breast and ovarian cancer by providing comprehensive, personalized services in an atmosphere of warmth and compassion.

http://www.bcconnections.org

Last Updated: 21 May 2015

View Details
No Stomach For Cancer

Our mission is to support research and united the caring power of people worldwide affected by stomach cancer. We advance awareness and education about stomach cancer, including Hereditary Diffuse Gastric Cancer (HDGC), provide a support network for affected families, and support research for screening, early detection, treatment, and prevention of stomach cancer.

http://www.nostomachforcancer.org

Last Updated: 7 Jan 2016

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Invasive lobular carcinoma" returned 93 free, full-text research articles on human participants. First 3 results:

Invasive lobular carcinoma of the breast: A special histological type compared with invasive ductal carcinoma.
 

Author(s): Zheling Chen, Jiao Yang, Shuting Li, Meng Lv, Yanwei Shen, Biyuan Wang, Pan Li, Min Yi, Xiao'ai Zhao, Lingxiao Zhang, Le Wang, Jin Yang

Journal:

 

The clinical outcomes and therapeutic strategies for infiltrating ductal carcinoma (IDC) and infiltrating lobular carcinoma (ILC) are not uniform. The primary objectives of this study were to identify the differences in the clinical characteristics and prognoses between ILC and IDC, ...

Last Updated: 31 Dec 1969

Go To URL
Pancreatic metastasis from invasive pleomorphic lobular carcinoma of the breast: a rare case report.
 

Author(s): Xiangjie Sun, Ke Zuo, Dan Huang, Baohua Yu, Yufan Cheng, Wentao Yang

Journal:

 

Invasive pleomorphic lobular carcinoma (PLC) is an aggressive subtype of invasive lobular carcinoma of the breast, which has its own histopathological and biological features. The metastatic patterns for PLC are distinct from those of invasive ductal carcinoma. In addition, pancreatic ...

Last Updated: 31 Dec 1969

Go To URL
Relative effectiveness of adjuvant chemotherapy for invasive lobular compared with invasive ductal carcinoma of the breast.
 

Author(s): Schelomo Marmor, Jane Yuet Ching Hui, Jing Li Huang, Scott Kizy, Heather Beckwith, Anne H Blaes, Natasha M Rueth, Todd M Tuttle

Journal: Cancer. 2017 Aug;123(16):3015-3021.

 

Invasive ductal carcinoma (IDC) and invasive lobular carcinoma (ILC) have distinct clinical, pathologic, and genomic characteristics. The objective of the current study was to compare the relative impact of adjuvant chemotherapy on the survival of patients with ILC versus those with IDC.

Last Updated: 31 Dec 1969

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Invasive lobular carcinoma" returned 6 free, full-text review articles on human participants. First 3 results:

Invasive lobular carcinoma of the breast: morphology, biomarkers and 'omics.
 

Author(s): Amy E McCart Reed, Jamie R Kutasovic, Sunil R Lakhani, Peter T Simpson

Journal:

 

Invasive lobular carcinoma of the breast is the most common 'special' morphological subtype of breast cancer, comprising up to 15% of all cases. Tumours are generally of a good prognostic phenotype, being low histological grade and low mitotic index, hormone receptor positive and ...

Last Updated: 31 Dec 1969

Go To URL
Synchronous gastric and colonic metastases of invasive lobular breast carcinoma: case report and review of the literature.
 

Author(s): Adam Charles Critchley, James Harvey, Michael Carr, Obi Iwuchukwu

Journal: Ann R Coll Surg Engl. 2011 Jul;93(5):e49-50.

 

Breast cancer is the most common malignancy in women and the main cause of cancer death in the UK. Gastrointestinal (GI) tract metastasis and carcinomatosis from primary breast cancer are rare but breast cancer is the second most common primary malignancy to metastasise to the GI ...

Last Updated: 31 Dec 1969

Go To URL
Relapse of invasive lobular carcinoma.
 

Author(s): Elizabeth Mallon, Zsuzsanna Varga

Journal: Breast Dis. ;30():53-6.

 

Last Updated: 31 Dec 1969

Go To URL
 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Palbociclib and Endocrine Therapy for LObular Breast Cancer Preoperative Study (PELOPS)
 

Status: Recruiting

Condition Summary: Breast Cancer

 

Last Updated: 30 Jan 2018

Go to URL
Single Fraction Intraoperative Radiotherapy
 

Status: Recruiting

Condition Summary: Invasive Ductal and Invasive Lobular Breast Carcinoma; Stage 0 Breast Carcinoma; Stage I Breast Carcinoma; Stage II Breast Carcinoma

 

Last Updated: 14 Oct 2014

Go to URL
Fulvestrant and/or Anastrozole in Treating Postmenopausal Patients With Stage II-III Breast Cancer Undergoing Surgery
 

Status: Recruiting

Condition Summary: Estrogen Receptor-positive Breast Cancer; HER2-negative Breast Cancer; Invasive Ductal Breast Carcinoma; Invasive Lobular Breast Carcinoma; Recurrent Breast Cancer; Stage II Breast Cancer; Stage IIIA Breast Cancer; Stage IIIB Breast Cancer; Stage IIIC Breast Cancer

 

Last Updated: 5 Sep 2018

Go to URL