Pseudoaldosteronism

Common Name(s)

Pseudoaldosteronism, Liddle Syndrome

Liddle syndrome is a rare, inherited form of high blood pressure (hypertension). The condition is characterized by severe, early-onset hypertension associated with decreased levels of potassium, renin and aldosterone in blood plasma. Children usually have no symptoms; adults can present with symptoms of low potassium levels (hypokalemia) such as weakness, fatigue, muscle pain (myalgia), constipation or palpitations. It is caused by mutations in either the SCNN1B or SCNN1G genes and is inherited in an autosomal dominant manner. Treatment may include a low sodium diet and potassium-sparing diuretics to reduce blood pressure and normalize potassium levels. Conventional anti-hypertensive therapies are not effective.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pseudoaldosteronism" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pseudoaldosteronism" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Pseudoaldosteronism" returned 13 free, full-text research articles on human participants. First 3 results:

A semi-physiologically based pharmacokinetic pharmacodynamic model for glycyrrhizin-induced pseudoaldosteronism and prediction of the dose limit causing hypokalemia in a virtual elderly population.
 

Author(s): Ruijuan Xu, Xiaoquan Liu, Jin Yang

Journal:

 

Glycyrrhizin (GL) is a widely used food additive which can cause severe pseudoaldosteronism at high doses or after a long period of consumption. The aim of the present study was to develop a physiologically based pharmacokinetic (PBPK) pharmacodynamic (PD) model for GL-induced pseudoaldosteronism ...

Last Updated: 31 Dec 1969

Go To URL
3-Monoglucuronyl-glycyrrhretinic acid is a substrate of organic anion transporters expressed in tubular epithelial cells and plays important roles in licorice-induced pseudoaldosteronism by inhibiting 11β-hydroxysteroid dehydrogenase 2.
 

Author(s): Toshiaki Makino, Kyoko Okajima, Rie Uebayashi, Nobuhiro Ohtake, Katsuhisa Inoue, Hajime Mizukami

Journal: J. Pharmacol. Exp. Ther.. 2012 Aug;342(2):297-304.

 

Licorice (glycyrrhiza root) has been used as a herbal medicine worldwide with its main active constituent being glycyrrhizin (GL). Licorice sometimes causes adverse effects such as inducing pseudoaldosteronism by inhibiting type 2 11β-hydroxysteroid dehydrogenase (11β-HSD2) caused ...

Last Updated: 31 Dec 1969

Go To URL
[Pseudoaldosteronism in an elderly man believed to be caused by the health food Shin-Gojoshin].
 

Author(s): Ikki Sakuma, Takahiro Ishikawa, Masaki Fujimoto, Minoru Takemoto, Koutaro Yokote

Journal: Nihon Ronen Igakkai Zasshi. 2012 ;49(5):617-21.

 

We report a 67-year-old man in whom pseudoaldosteronism developed following consumption of the health food Shin-Gojoshin. The patient began consuming Shin-Gojoshin in February 2007. His serum potassium level, which was within the normal range until he began consumption, gradually ...

Last Updated: 31 Dec 1969

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Pseudoaldosteronism" returned 1 free, full-text review articles on human participants. First 3 results:

3-Monoglucuronyl glycyrrhretinic acid is a possible marker compound related to licorice-induced pseudoaldosteronism.
 

Author(s): Toshiaki Makino

Journal: Biol. Pharm. Bull.. 2014 ;37(6):898-902.

 

One of the most common adverse effects of traditional Japanese kampo and traditional Chinese medicine is pseudoaldosteronism caused by licorice. In this review, the authors describe the mechanisms of licorice-induced pseudoaldosteronism by the pharmacokinetics of chemical constituents ...

Last Updated: 31 Dec 1969

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.