Limb-body wall complex

Common Name(s)

Limb-body wall complex

Limb-body wall complex (LBWC) refers to a congenital disorder characterized by very severe limb defects and anterior body wall defects. The complex includes two or three of the following defects: exencephaly or encephalocele with facial clefts (a rare condition in which there are areas of absent bone and sometimes overlying skin that may occur on one or both sides of the face), thoracoschisis (birth defect in which organs in the thoracic area stick out) and/or abdominoschisis (birth defect in which the organs in the abdominal area stick out), and limb defects. Scoliosis and a short umbilical cord are also frequently found. Other findings such as defects of the internal organs (heart, intestines, genitals, or urinary tract) and persistence of the three separate fluid-filled spaces that lie outside the developing embryo (extraembryonic coelom) have been seen in cases of LBWC. The exact cause of the complex has not been determined.  
 

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Condition Specific Organizations

Following organizations serve the condition "Limb-body wall complex" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Limb-body wall complex" returned 11 free, full-text research articles on human participants. First 3 results:

Limb Body Wall Complex Associated with Placenta Accreta: A Mere Coincidence or a Sign of an Etiopathogenic Link?
 

Author(s): Marcos Masaru Okido, Aderson Tadeu Berezowski, Sandra Regina Marques Carvalho, Geraldo Duarte, Ricardo de Carvalho Cavalli, Alessandra Cristina Marcolin

Journal: Rev Bras Ginecol Obstet. 2017 Mar;39(3):142-146.

 

A case was reported of a fetus with the anomaly of limb body wall complex associated with placenta accreta. To date, only one account of this condition has been published in the world literature. Due to the low frequency of both complications, the hypothesis has been raised that this ...

Last Updated: 31 Dec 1969

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Significance of fibrotic bands in utero--Amniotic band sequence with limb body wall complex: A rare case of fetal autopsy.
 

Author(s): P Lekshmi Devi, P J Cicy, Renu Thambi, Usha Poothiode

Journal: Indian J Pathol Microbiol. ;58(4):528-30.

 

Amniotic band sequence (ABS) includes a wide spectrum of abnormalities resulting from entrapment of various fetal parts from a disrupted amnion, ranging from a mere constriction ring affecting a finger to a fatal form called limb body wall complex (LBWC). Reported cases of ABS with ...

Last Updated: 31 Dec 1969

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Possible Genetic Origin of Limb-Body Wall Complex.
 

Author(s): David C Gajzer, Alicia Cristina Hirzel, Gaurav Saigal, Claudia Patricia Rojas, Maria Matilde Rodriguez

Journal: Fetal Pediatr Pathol. 2015 ;34(4):257-70.

 

Limb body wall complex (LBWC) is characterized by multiple severe congenital malformations including an abdominal and/or thoracic wall defect covered by amnion, a short or absent umbilical cord with the placenta almost attached to the anterior fetal wall, intestinal malrotation, scoliosis, ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Limb-body wall complex" returned 3 free, full-text review articles on human participants. First 3 results:

Limb-body wall complex in one fetus of a dizygotic twin pregnancy conceived by egg donation, in vitro fertilization and embryo transfer: prenatal diagnosis and literature review.
 

Author(s): Chih-Ping Chen, Maw-Shuan Lee, Fuu-Jen Tsai, Ming-Chao Huang, Schu-Rern Chern, Wayseen Wang

Journal: Taiwan J Obstet Gynecol. 2009 Dec;48(4):446-50.

 

Last Updated: 31 Dec 1969

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[Antenatal diagnosis of limb body wall complex].
 

Author(s): P Deruelle, R Hay, D Subtil, M P Chauvet, A Duroy, J Decocq, F Puech

Journal: J Gynecol Obstet Biol Reprod (Paris). 2000 Jun;29(4):385-91.

 

The "limb body wall complex" or LBWC is a rare polymalformative syndrome. Two distinct phenotypes of which were recently described: one form with "placento-cranial" adhesion and the other with "placento-abdominal" adhesion. Coelosomia is found in all cases, it variably coexists with ...

Last Updated: 31 Dec 1969

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Complete absence of external genitalia in limb-body wall complex: two cases.
 

Author(s): A Litwin, P Merlob, M Grunebaum

Journal: J. Med. Genet.. 1988 May;25(5):340-3.

 

Two neonates with limb-body wall complex (LBWC) and complete absence of the external genitalia are presented. Our patients are the sixth and seventh cases of complete absence of the external genitalia recorded in English publications and the first two cases associated with LBWC. The ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.